Interneuronal signalling is involved in induction of collateral sprouting of nociceptive axons

Bajrović, Fajko F.; Kovačič, Uroš; Pavčnik, Maja; Sketelj, Janez

doi:10.1016/s0306-4522(01)00588-7

Cited by 29 publications

(14 citation statements)

References 48 publications

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“…One of the reasons for the active research into ETSN is an ongoing discussion about whether it is necessary to create a perineurial window to initiate collateral axon sprouting. 1,2,8,11 In addition, only a limited number of motor neurons have the capacity to send out collateral sprouts from intact axons. 6 Few clinical studies dealing with ETSN are available, and those that are represent mainly either case reports or reports involving only a few patients.…”

Section: ©Aans 2013mentioning

confidence: 99%

End-to-side neurorrhaphy in brachial plexus reconstruction

Haninec¹,

Mencl²,

Kaiser³

2013

JNS

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Object. Although a number of theoretical and experimental studies dealing with end-to-side neurorrhaphy (ETSN) have been published to date, there is still a considerable lack of clinical trials investigating this technique. Here, the authors describe their experience with ETSN in axillary and musculocutaneous nerve reconstruction in patients with brachial plexus palsy.Methods. From 1999 to 2007, out of 791 reconstructed nerves in 441 patients treated for brachial plexus injury, the authors performed 21 axillary and 2 musculocutaneous nerve sutures onto the median, ulnar, or radial nerves. This technique was only performed in patients whose donor nerves, such as the thoracodorsal and medial pectoral nerves, which the authors generally use for repair of axillary and musculocutaneous nerves, respectively, were not available. In all patients, a perineurial suture was carried out after the creation of a perineurial window.Results. The overall success rate of the ETSN was 43.5%. Reinnervation of the deltoid muscle with axillary nerve suture was successful in 47.6% of the patients, but reinnervation of the biceps muscle was unsuccessful in the 2 patients undergoing musculocutaneous nerve repair.Conclusions. The authors conclude that ETSN should be performed in axillary nerve reconstruction but only when commonly used donor nerves are not available.

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Section: ©Aans 2013mentioning

confidence: 99%

End-to-side neurorrhaphy in brachial plexus reconstruction

Haninec¹,

Mencl²,

Kaiser³

2013

JNS

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“…In our experimental model, the sural nerve was used as the donor, which seems to be very suitable for studying the sprouting specifically of myelinated sensory axons, because > 93% of its myelinated axons are sensory. 58,59 Several observations discussed in detail in our previous papers 11,57,60 demonstrated that in our experimental model the axons in the recipient nerve were axon sprouts (either collateral from uninjured axons or regenerative from injured axons) from the donor nerve, and ruled out the possibility of inadvertent invasion of the regenerating axons from some other source, for example, from the proximal nerve stumps of the transected adjacent peroneal and tibial nerves.…”

Section: Discussionmentioning

confidence: 57%

“…42,45,67 However, once the axon sprouting from the donor nerve is enhanced, the ingrowth of sprouting axons into the recipient nerve depends upon the soluble and insoluble factors provided by the Schwann cells from the recipient nerve. 47,60 Therefore, it is possible that even the small holes created by needle penetration and sutures through the epineurium during the end-to-side repair are sufficient to enhance growth factor diffusion or Schwann cell migration in the early postoperative period. It is interesting in this regard, that during 5 weeks after the stripping of the perineurium, a new sheath, closely resembling normal perineurium, became organized throughout the length of the injured nerve segment.…”

Section: Kovač Ič Et Almentioning

confidence: 99%

Influence of Breaching the Connective Sheaths of the Donor Nerve on Its Myelinated Sensory Axons and on Their Sprouting into the End-to-Side Coapted Nerve in the Rat

Kovačič

Žele²,

Tomšič³

et al. 2012

Journal of Neurotrauma

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The influence of breaching the connective sheaths of the donor sural nerve on axonal sprouting into the end-to-side coapted peroneal nerve was examined in the rat. In parallel, the effect of these procedures on the donor nerve was assessed. The sheaths of the donor nerve at the coaptation site were either left completely intact (group A) or they were breached by epineurial sutures (group B), an epineurial window (group C), or a perineurial window (group D). In group A, the compound action potential (CAP) of sensory axons was detected in *10% and 40% of the recipient nerves at 4 and 8 weeks, respectively, which was significantly less frequently than in group D at both recovery periods. In addition, the number of myelinated axons in the recipient nerve was significantly larger in group D than in other groups at 4 weeks. At 8 weeks, the number of axons in group A was only *15% of the axon numbers in other groups ( p < 0.05). Focal subepineurial degenerative changes in the donor nerves were only seen after 4 weeks, but not later. The average CAP area and the total number of myelinated axons in the donor nerves were not different among the experimental groups. In conclusion, myelinated sensory axons are able to penetrate the epiperineurium of donor nerves after end-to-side nerve coaption; however, their ingrowth into recipient nerves is significantly enhanced by breaching the epiperineurial sheets at the coaptation site. Breaching does not cause permanent injury to the donor nerve.

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“…Another important factor affecting collateral sprouting is nerve growth factor (NGF) [5,51]. NGF is produced in end organs following nerve injury.…”

Section: Discussionmentioning

confidence: 99%