Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life

Yamamoto, Sayuri; Kawamura, Yasuhiko; Yamamoto, Kazuhiro; Yamaguchi, Yoshiharu; Tamura, Yasuhiro; Izawa, Shinya; Nakagawa, Hiroaki; Wakita, Yoshinori; Hijikata, Yasutaka; Ebi, Masahide; Funaki, Yasushi; Ohashi, Wataru; Ogasawara, Nagahisa; Sasaki, Makoto; Maekawa, Masato; Kasugai, Kunio

doi:10.5056/jnm20135

Cited by 12 publications

(12 citation statements)

References 40 publications

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“…Although the relationship between SD and DGBI is incompletely understood, latest studies indicated that there were close associations of SD with lower gastrointestinal symptoms. In a cross-sectional internet-based survey for Japanese population, Yamamoto et al (2021) tested the relationship between chronic constipation and sleep and the authors demonstrated that subjects with constipation and poor sleep experienced severe symptoms and had poor quality of life, which is consistent with our findings. Jiang et al (2017) investigated 126 patients with chronic constipation and reported that patients with sleep disorders had worse constipation symptoms evaluated by the constipation scoring system (CSS) scale, compared to those without sleep disorders ( P = 0.031).…”

Section: Discussionsupporting

confidence: 87%

Sleep Deficiency Is Associated With Exacerbation of Symptoms and Impairment of Anorectal and Autonomic Functions in Patients With Functional Constipation

et al. 2022

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ObjectiveSleep deficiency (SD) is commonly seen in patients with functional constipation (FC). Our aim was to determine whether the presence of SD would influence symptoms, anorectal motility, sensation, and autonomic function in FC patients.Materials and MethodsA total of 85 FC patients with SD and 193 FC patients without SD underwent high-resolution anorectal manometry. SD was assessed by using the Pittsburgh Sleep Quality Index (PSQI) score. Participants were required to fill in the entire questionnaires, including Patients’ Constipation-symptoms, State-Trait Anxiety Inventory, and Hamilton Depression Scale. Autonomic dysfunction was studied by recording the heart rate variability. Multiple logistic regression was performed to explore the potential risk factors for anorectal function.ResultsFunctional constipation patients with SD had a higher total score of constipation symptom (P < 0.001), in comparison with those without SD. FC patients with SD demonstrated significantly lower threshold volume for first sensation (P < 0.001) and urge (P < 0.001), as compared to those without SD. The PSQI score positively correlated with constipation symptom total score (P < 0.001), and negatively correlated with threshold volume for first sensation (P < 0.001) and urge (P < 0.001). FC patients with SD had a reduced vagal activity (P = 0.016) and a higher sympathetic activity as compared to those without SD (P = 0.003). Multivariate logistic regression revealed that SD, anxiety and depression were independent risk factors for anorectal function, with SD exhibiting the highest degree of association with first sensation (OR: 4.235).ConclusionSleep deficiency is associated with worse constipation related symptoms, altered anorectal function and perception, and impaired autonomic function in FC patients.

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Section: Discussionsupporting

confidence: 87%

Sleep Deficiency Is Associated With Exacerbation of Symptoms and Impairment of Anorectal and Autonomic Functions in Patients With Functional Constipation

et al. 2022

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“…In 350 BC, Astoria elaborated in his book Sleep and Insomnia that sleep is caused by hot steam produced by the stomach during digestion [ 44 ]. Some studies have shown a two-way link between chronic constipation and sleep quality, i.e., sleep disturbances may affect bowel function and increase the risk of gastrointestinal disorders, and constipation may also affect sleep quality [ 45 , 46 ]. In our study, the same results were found in university students, i.e., there was an association between FC and sleep status in university students, with those suffering from FC experiencing poor sleep status.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Functional Constipation among Students of a Chinese University: A Cross-Sectional Study

Zhang

Lin

et al. 2022

Nutrients

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Functional constipation (FC) is prevalent worldwide and is an increasingly prominent problem among university students. However, there is a paucity of research on FC in university students. This study aimed to assess the prevalence of FC among Chinese university students by the Rome III criteria and investigate its associated factors. This cross-sectional study was conducted by online questionnaires among 929 university students at a Chinese university. Food consumption was assessed with the Semi-Quantitative Food Frequency Questionnaire (SQFFQ) and dietary patterns were analyzed using factor analysis. A binary logistic regression model was applied to clarify FC-associated factors. The prevalence of FC among university students was 5.1%. Interestingly, among university students, the prevalence of FC with “complex” dietary pattern was significantly higher than those with “vegetable, fruit, egg and milk-based” and “livestock and aquatic product-based” dietary pattern (9.9% vs. 3.1% vs. 2.8%, p < 0.001). The prevalence of FC was significantly higher among university students with moderate to severe sleep disorders than those with the other sleep status (χ2 = 18.100, p < 0.001). Furthermore, after adjusting the covariates, “complex” dietary pattern (OR = 4.023, p < 0.001), moderate to severe sleep disorders (OR = 3.003, p = 0.006), overeating (OR = 2.502, p = 0.032), long mealtime (>30 min) (OR = 6.001, p = 0.007), and poor defecation habits (OR = 3.069, p = 0.042) were positively associated with FC among university students. Based on the above-associated factors for FC, improving dietary patterns and sleep status and developing good bowel and dietary habits are essential to prevent and alleviate university students’ FC.

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“…Studies have also shown that poor sleep quality is a risk factor for constipation and other GI symptoms. 57,58 Sleep quality is closely related to anorectal sensitivity, autonomic nervous function, and mental health.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, inactivity may aggravate the occurrence and development of constipation and its overlapping symptoms. Studies have also shown that poor sleep quality is a risk factor for constipation and other GI symptoms 57,58 . Sleep quality is closely related to anorectal sensitivity, autonomic nervous function, and mental health.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the impact of overlapping upper gastrointestinal symptoms on the clinical characteristics of patients with functional constipation, along with risk factor analysis

Zhu,

Li,

Lyu

et al. 2024

J of Digest Diseases

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ObjectivesFunctional constipation (FC), a common functional gastrointestinal disorder, is usually overlapping with upper gastrointestinal symptoms (UGS). We aimed to explore the clinical characteristics of patients with FC overlapping UGS along with the related risk factors.MethodsThe differences in the severity of constipation symptoms, psychological state, quality of life (QoL), anorectal motility and perception function, autonomic function, and the effect of biofeedback therapy (BFT) among patients with FC in different groups were analyzed, along with the risk factors of overlapping UGS.ResultsCompared with patients with FC alone, those with FC overlapping UGS had higher scores in the Patient Assessment of Constipation Symptoms and Self‐Rating Anxiety Scale and lower scores in the Short Form‐36 health survey (P < 0.05). Patients with FC overlapping UGS also had lower rectal propulsion, more negative autonomic nervous function, and worse BFT efficacy (P < 0.05). Overlapping UGS, especially overlapping functional dyspepsia, considerably affected the severity of FC. Logistic regression model showed that age, body mass index (BMI), anxiety, exercise, and sleep quality were independent factors influencing overlapping UGS in patients with FC.ConclusionsOverlapping UGS reduces the physical and mental health and the QoL of patients with FC. It also increases the difficulty in the treatment of FC. Patient's age, BMI, anxiety, physical exercise, and sleep quality might be predictors for FC overlapping UGS.

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Internet Survey of Japanese Patients With Chronic Constipation: Focus on Correlations Between Sleep Quality, Symptom Severity, and Quality of Life

Cited by 12 publications

References 40 publications

Sleep Deficiency Is Associated With Exacerbation of Symptoms and Impairment of Anorectal and Autonomic Functions in Patients With Functional Constipation

Sleep Deficiency Is Associated With Exacerbation of Symptoms and Impairment of Anorectal and Autonomic Functions in Patients With Functional Constipation

Factors Associated with Functional Constipation among Students of a Chinese University: A Cross-Sectional Study

Evaluation of the impact of overlapping upper gastrointestinal symptoms on the clinical characteristics of patients with functional constipation, along with risk factor analysis

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