Interne Therapie

Gw, Korting

doi:10.1007/bf00502827

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…84 Mercury toxicity in utero can lead to mental retardation, seizures, and other neurological problems. 85 Mercury vapor is highly lipid soluble, which allows it to readily cross cellular membranes. Inorganic mercury lasts for a long time in the body and bioaccumulates.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, the vaccine preservative thimerosal contains organic ethylmercury (EtHg), which does not accumulate, is quickly excreted, and has not been found to cause health problems. 85 Multiple studies examining the effects of vaccines have found no credible association between thimerosal and ASD. 1,88 Half of the studies that examined levels of Hg in hair found that there was a significantly positive association with ASD.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to Aluminum, Cadmium, and Mercury and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis

Sulaiman

Wang

Ren

2020

Chem. Res. Toxicol.

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Autism spectrum disorder (ASD) is a complex neurobehavioral disorder that is believed to be multifactorial in origin. As the incidence of ASD is rising along with industrialization, and because certain metals have been linked to neurological problems, it is important to consider whether such metals may play a role in the development of ASD. Previously, we performed a meta-analysis of existing literature to examine the potential link between inorganic arsenic and lead exposure and ASD. This is a continuation of that study investigating the association of the exposure to aluminum (Al), cadmium (Cd), and mercury (Hg) and ASD. These metals were chosen because they are abundant in our environment, are known to cause neurological problems in humans, and have multiple published studies examining their potential links with ASD. Following the same approach as our previous paper, we conducted a systematic review of the existing literature and performed a meta-analysis to evaluate the current evidence regarding these metals and their potential relationship with autism. We reviewed 18 studies on Al, 18 on Cd, and 23 on Hg, and the individual studies showed inconsistent results. When the measurements were integrated into the meta-analysis, we found significant associations between all the metals and ASD, but the associations were not always in the same direction. Levels of Hg in hair, urine, and blood were all positively associated with ASD. Levels of Al in hair and urine were positively associated with ASD, while levels of Al in blood were negatively associated. In comparison, levels of Cd in hair and urine were negatively associated with ASD. These results imply that, while these metals are all neurotoxic, their impact on the development of ASD and their modes of action could be different. Further research is warranted to examine the longitudinal effects of these toxic metals on the risk of ASD, to assess the critical period when exposure may affect development, and to investigate potential factors that may enhance or ameliorate the effect of metals. Overall, these findings support policies that advocate limiting exposure to neurotoxic metals, particularly for pregnant women and young children, in order to help reduce the rising incidence of ASD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exposure to Aluminum, Cadmium, and Mercury and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis

Sulaiman

Wang

Ren

2020

Chem. Res. Toxicol.

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“…Two of the patients in my series had a 'marfanoid' stature but there was no further similarity. Meara (1958) demonstrated a patient with the Ehlers-Danlos syndrome and elastoma perforans, but apart from isolated case descriptions by Zambal (1958) and Korting (1966) there are no other reports of these two conditions occurring together, and it is possible, therefore, that they were chance associations. Dr E J Moynahan: Dr Beighton's excellent study of Ehlers-Danlos syndrome clearly demonstrates the value of population genetic studies in inheritable disorders of the skin and it is only by such studies that a true picture of their clinical range and differentiation can be obtained.…”

mentioning

confidence: 99%