International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor

Moore, David D.; Kato, Shigeaki; Xie, Wen; Mangelsdorf, David J.; Schmidt, Daniel R.; Xiao, Rui; Kliewer, Steven A.

doi:10.1124/pr.58.4.6

Cited by 181 publications

(161 citation statements)

References 199 publications

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“…On the other hand, CYPs can also lead to an increased affinity of lipophilic molecules for enzymes and/or receptors. Thus, hydroxylation of various lipophilic molecules, such as cholesterol, ergosterol, bile acids, retinoids, and vertebrate steroids, by CYPs can yield ligands that activate nuclear receptors (39)(40)(41)(42). Indeed, selective expression of CYPs in specific tissues is an important mechanism for regulating the actions of vertebrate steroids and other ligands.…”

Section: Xenobiotic-metabolizing Cyps Are Ancestors Of Steroidogenic En-mentioning

confidence: 99%

“…Like xenobiotic-metabolizing CYPs, some nuclear receptors are xenobiotic sensors, in that these transcription factors bind a wide range of molecules with micromolar affinity (42). An example of an ancient liganded receptor system is the NR1H/NR1I/NR1J group containing FXR, LXR, ECR, PXR, CAR, and VDR in vertebrates and also DHR96 in Drosophila and DAF12 in nematodes.…”

Section: Xenobiotic-metabolizing Cyps Are Ancestors Of Steroidogenic En-mentioning

confidence: 99%

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Independent elaboration of steroid hormone signaling pathways in metazoans

Markov

Tavares

Dauphin‐Villemant

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

168

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Steroid hormones regulate many physiological processes in vertebrates, nematodes, and arthropods through binding to nuclear receptors (NR), a metazoan-specific family of ligand-activated transcription factors. The main steps controlling the diversification of this family are now well-understood. In contrast, the origin and evolution of steroid ligands remain mysterious, although this is crucial for understanding the emergence of modern endocrine systems. Using a comparative genomic approach, we analyzed complete metazoan genomes to provide a comprehensive view of the evolution of major enzymatic players implicated in steroidogenesis at the whole metazoan scale. Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages, and that steroidogenic cytochrome P450 enzymes descended from those that detoxify xenobiotics. evolution ͉ nuclear-receptor ligand ͉ steroidogenesis

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Section: Xenobiotic-metabolizing Cyps Are Ancestors Of Steroidogenic En-mentioning

confidence: 99%

Section: Xenobiotic-metabolizing Cyps Are Ancestors Of Steroidogenic En-mentioning

confidence: 99%

Independent elaboration of steroid hormone signaling pathways in metazoans

Markov

Tavares

Dauphin‐Villemant

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

168

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show abstract

“…In fact, activated VDR acts as a transcriptional factor forming a heterodimer with the retinoid-X receptor and then binding to response elements on DNA, resulting in expression or repression of specific target genes (Moore et al, 2006). Among these, the IGF-1 transcriptional pathway falls under the target of VDR modulation (Jurutka et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Role of Angiotensin-Converting Enzyme and Vitamin D Receptor Gene Polymorphisms in Cancer Anorexia-Cachexia Syndrome

Fabris

Biagioni²,

Punzi

et al. 2012

American Journal of Immunology

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The ubiquitin-proteasome pathway is a crucial connection between aberrant immune system activation, systemic inflammation and Cancer Anorexia-Cachexia Syndrome (CACS), a syndrome that culminates in hyper-activation of the ubiquitin-proteasome pathway. Angiotensin directly up-regulates this pathway, while vitamin D down-regulates it indirectly through the insulin-like growth factor-1 pathway. We investigated the genetic predisposition towards CACS in a cancer population, examining Insertion/Deletion (I/D) polymorphism of angiotensin-converting enzyme gene and FokI and BsmI polymorphisms of vitamin D receptor gene. Sixty-two cancer patients were recruited and divided into three groups: primary cachectic (C1, n = 14; dysmetabolic body weight loss â¥5% in 6 months); secondary cachectic (C2, n = 34; similar weight loss, mechanic or iatrogenic origin); and non-cachectic (NC, n = 16). C2+NC were merged in the control group. The three groups showed significant differences in average prognostic inflammatory nutritional index (C1: 26.4Â±23.4; C2: 5.4Â±5.6; NC: 0.37Â±0.5), C-reactive protein serum levels (C1: 6.6Â±2.1; C2: 2.4Â±2.2; NC: 1.0Â±2.0 mg/dL), albumin serum levels (C1: 3.1Â±0.6; C2: 3.5Â±0.4; NC 3.7Â±0.6 g/dL), weight loss (C1: 22Â±8; C2: 15Â±6.7; NC 5Â±6%) and life expectancy (C1: 6.4Â±3.3; C2: 25Â±28; NC: 45Â±25 months). However, none of the chosen polymorphisms showed any statistically significant correlation with CACS. The complexity of the changes of the immune system in the chronic inflammation state associated with CACS is far greater than expected and further studies are required to identify genetic independent markers of progression toward CACS.

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“…The effects of vitamin D are exerted through the vitamin D receptor (VDR), which is a member of the nuclear receptor family of transcription factors (Moore et al, 2006). The VDR gene, which is located on chromosome 12cen-q12, contains 11 exons and spans approximately 75 kb of genomic DNA (Taymans et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis

Sun¹,

Cai²

2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have evaluated the association between FokI polymorphisms in the vitamin D receptor (VDR) gene and tuberculosis risk. However, the spe cific association remains controversial. In this study, we performed a meta-analysis to assess the association between the VDR gene FokI polymorphism and tuberculosis. Published studies from the PubMed and Embase databases were retrieved. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed-or random-effect models. Overall, a significant association was found between FokI polymorphism and tuberculosis risk when all studies were pooled (ff vs FF: OR = 1.36, 95%CI = 1.11-1.66; ff vs Ff: OR = 1.38, 95%CI = 1.14-1.67; dominant model: OR = 0.73, 95%CI = 0.61-0.88). In subgroup analysis by race, a significant association between FokI polymorphism and tuberculosis risk was observed in Asians (ff vs FF: OR = 1.71, 95%CI = 1.02-2.85; ff vs Ff: OR = 1.86, 95%CI = 1.40-2.47; dominant model: OR = 0.55, 95%CI = 0.42-0.72), and no significant association was observed among Caucasians and Africans. In conclusion, the FokI polymorphism in the VDR gene may be related to an increased risk of tuberculosis in Asians. Further large and well-designed studies are needed to confirm these conclusions.

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International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor

Cited by 181 publications

References 199 publications

Independent elaboration of steroid hormone signaling pathways in metazoans

Independent elaboration of steroid hormone signaling pathways in metazoans

Role of Angiotensin-Converting Enzyme and Vitamin D Receptor Gene Polymorphisms in Cancer Anorexia-Cachexia Syndrome

Vitamin D receptor FokI gene polymorphism and tuberculosis susceptibility: a meta-analysis

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