International survey on opinions and use of minimally invasive surgery in small bowel neuroendocrine neoplasms

Kaçmaz, Enes; Engelsman, Anton F.; Bemelman, Willem A.; Tanis, Pieter J.; Dijkum, E. J. M. Nieveen van

doi:10.1016/j.ejso.2021.11.011

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…Since most surgeries for patients with i-NETs are performed minimally invasively at our institution, our findings require corroboration by studies elsewhere, given variable experience in advanced MIS worldwide. 23 On the other hand, as a single-institution study of a large number of patients undergoing MIS for i-NETs, a major strength was the ability to capture granular data, such as clinicopathological features, that may not be present in large databases. Second, 108/168 patients included in our current study overlap with those in our previous publications on MIS for iNETs, 9,11 and there remains the possibility of duplication or redundancy in the data.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Survival Outcomes After Minimally Invasive Surgery for Ileal Neuroendocrine Tumors

Yogo,

Paciorek,

Kasai

et al. 2024

Ann Surg Oncol

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Background Ileal neuroendocrine tumors (i-NETs) are characterized by their multifocality and bulky mesenteric mass. Having shown that minimally invasive surgery (MIS) utilizing a hand-access port device has favorable short-term outcomes and achieves the goals of surgery for i-NETs, we sought to analyze long-term survival outcomes of MIS. Methods One hundred and sixty-eight patients who underwent resection of primary i-NETs at a single institution between January 2007 and February 2023 were retrospectively studied. Patients were categorized into the MIS or open surgery cohorts on an intention-to-treat basis. Open surgery was selected mainly based on the need for hepatectomy or bulky mesenteric mass resection. Overall survival was analyzed using log-rank tests with propensity score matching (PSM) and Cox proportional hazards regression. PSM was performed to reduce standardized mean differences of the variables to <0.2. Results Overall, 129 (77%) patients underwent MIS and 39 (23%) underwent open surgery. Twenty-seven MIS patients were converted to an open procedure. The median follow-up time was 49 months (interquartile range 23–87 months). In the PSM cohorts, overall survival did not differ significantly between the MIS and open surgery cohorts {median 99 months (95% confidence interval [CI] 91–not applicable [NA]) vs. 103 months (95% CI 86–NA), p = 0.77; hazard ratio 0.87 (95% CI 0.33–2.2), p = 0.77}. Conclusions MIS is an alternative to open surgery for i-NETs, achieving similar short- and long-term oncological outcomes. Bulky mesenteric mass and a plan for concurrent liver resection are potential criteria for open surgery.

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Section: Discussionmentioning

confidence: 99%