International society of blood transfusion working party on red cell immunogenetics and terminology: report of the Seoul and London meetings

Storry, Jill R.; Castilho, Lilian; Chen, Q.; Daniels, Geoff; Denomme, Gregory A.; Flegel, Willy A.; Gassner, Christoph; Haas, Masja de; Hyland, Catherine A.; Keller, Margaret; Lomas‐Francis, Christine; Moulds, Joann M.; Nogués, Núria; Olsson, Martin L.; Peyrard, Thierry; Schoot, C. Ellen van der; Tani, Yoshihiko; Thornton, Nicole; Wagner, Franz F.; Wendel, Silvano; Westhoff, Connie M.; Yahalom, Vered

doi:10.1111/voxs.12280

Cited by 63 publications

(56 citation statements)

References 14 publications

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“…From a clinical perspective, the Rh blood group system is the most important of the 36 blood group systems (Storry et al , 2016) after ABO. Among the 54 blood group antigens in the Rh system, the RhD antigen is the most immunogenic and important in clinical practice (Gunson, et al , 1976; Urbaniak & Robertson, 1981; Storry et al , 2014).…”

Section: Clinical Importance Of the Rhd Blood Group Antigenmentioning

confidence: 99%

Serological weak D phenotypes: a review and guidance for interpreting the RhD blood type using the RHD genotype

2017

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Summary Approximately 0.2% to 1% of routine RhD blood typings result in a “serological weak D phenotype.” For more than 50 years, serological weak D phenotypes have been managed by policies to protect RhD-negative women of child-bearing potential from exposure to weak D antigens. Typically, blood donors with a serological weak D phenotype have been managed as RhD-positive, in contrast to transfusion recipients and pregnant women, who have been managed as RhD-negative. Most serological weak D phenotypes in Caucasians express molecularly defined weak D types 1, 2 or 3 and can be managed safely as RhD-positive, eliminating unnecessary injections of Rh immune globulin and conserving limited supplies of RhD-negative RBCs. If laboratories in the UK, Ireland and other European countries validated the use of potent anti-D reagents to result in weak D types 1, 2 and 3 typing initially as RhD-positive, such laboratory results would not require further testing. When serological weak D phenotypes are detected, laboratories should complete RhD testing by determining RHD genotypes (internally or by referral). Individuals with a serological weak D phenotype should be managed as RhD-positive or RhD-negative, according to their RHD genotype.

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Section: Clinical Importance Of the Rhd Blood Group Antigenmentioning

confidence: 99%

Serological weak D phenotypes: a review and guidance for interpreting the RhD blood type using the RHD genotype

2017

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“…13 Currently, there are 36 defined blood group systems, giving rise to .300 different antigens. 14 The genes underlying these systems form the foundation of this study.…”

Section: Introductionmentioning

confidence: 99%

Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project

et al. 2016

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“…The system is highly polymorphic and expresses 36 antigens, all encoded on a type II glycoprotein of 732 amino acids encoded by the KEL gene and its allelic variants [3,4]. Some of the Kell antigens have been classified into antithetical pairs, each represented by one HFA and its correspondent LFA, e.g.…”

Section: Introductionmentioning

confidence: 99%

Low-Frequency Blood Group Antigens in Switzerland

Gassner

Degenhardt

Meyer

et al. 2018

Transfus Med Hemother

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Background: High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested. Methods: In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA). Results: 326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products. Conclusion: Thorough comparison of minor allele frequencies using population genetics revealed heterogeneity of allele distributions among Swiss blood donors which may be explained by the topographical and cultural peculiarities of Switzerland. Moreover, geographically localized donor subpopulations are described which contain above-average numbers of individuals carrying rare blood group genotypes.

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International society of blood transfusion working party on red cell immunogenetics and terminology: report of the Seoul and London meetings

Cited by 63 publications

References 14 publications

Serological weak D phenotypes: a review and guidance for interpreting the RhD blood type using the RHD genotype

Serological weak D phenotypes: a review and guidance for interpreting the RhD blood type using the RHD genotype

Erythrogene: a database for in-depth analysis of the extensive variation in 36 blood group systems in the 1000 Genomes Project

Low-Frequency Blood Group Antigens in Switzerland

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