International seminar on oral leukoplakia and associated lesions related to tobacco habits

Axéll, Tony; Holmstrup, Palle; Kramer, I.R.H.; Jj, Pindborg; Shear, Mervyn

doi:10.1111/j.1600-0528.1984.tb01428.x

Cited by 218 publications

(135 citation statements)

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“…It is characterized by the presence of wavy white lines that radiate from a central erythematous area and occurs at the site of betel quid placement (Avon, 2004). All the lesions were diagnosed in accordance with international recommendations (World Health Organization, 1977;Axell et al, 1984;Gupta et al, 1989;Mehta et al, 1993;Zain et al, 1996;Rajalalitha et al, 2005).…”

Section: Screening Programmementioning

confidence: 99%

Prevalence and Correlation of Oral Lesions among Tobacco Smokers, Tobacco Chewers, Areca Nut and Alcohol Users

Sujatha¹,

Hebbar²,

Pai³

2012

Asian Pacific Journal of Cancer Prevention

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Introduction: The incidence of oral premalignant and malignant lesions is on the rise due to an increased number of people taking in tobacco and alcohol related habits. Material and Methods: 1028 patients with tobacco, alcohol and areca nut habits attending our Department of Oral Medicine and Radiology formed the study sample. An interviewer based questionnaire was used to record the habit details. All the patients were then examined clinically for the presence of lesions. Chi square and Fisher exact tests were used to assess the statistical significance of the study parameters. Results: Males had a higher prevalence and comprised 87.9% of the sample. The commonest habit in this study sample was smoking (39.2%) followed by smokeless tobacco use (28.1%). Out of the 1028 patients with habits 40% had no clinically detectable changes in their mucosa. Of the mucosal changes leukoplakia (14%) was the commonest. Conclusions: This study provided information about the habit trends in the patients visiting this institution. The study may serve as a useful tool in educating the patients about the deleterious effects of oral tobacco, alcohol and betel exposure.

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Section: Screening Programmementioning

confidence: 99%

Prevalence and Correlation of Oral Lesions among Tobacco Smokers, Tobacco Chewers, Areca Nut and Alcohol Users

Sujatha¹,

Hebbar²,

Pai³

2012

Asian Pacific Journal of Cancer Prevention

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“…Clinical diagnoses were based on criteria defined by Axell et al, 1984 adopted by the WHO workshop held in London in 2005. Histopathological examination of tissue specimens was performed blind by a trained oral pathologist (FS) to ascertain clinical diagnoses and to evaluate the existence and severity of epithelial dysplasia.…”

Section: Methodsmentioning

confidence: 99%

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Hassona¹,

Scully²,

Almangush³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: To determine the prevalence, types, and risk factors of oral potentially malignant disorders (OPMDs) among a group of Arab Jordanian dental patients, and to evaluate their awareness and attitudes toward early diagnosis and treatment. Materials and Methods: A total of 1,041 patients attending a University Hospital for dental care were examined for the presence of OPMDs. Histopathological examination was performed on all cases clinically diagnosed and patients were directly interviewed to evaluate their knowledge and attitudes toward early detection and treatment of oral cancer. Results: The prevalence of OPMDs overall was 2.8%. Lichen planus/lichenoid lesions were the most common lesions (1.8%) followed by leukoplakias (0.48%), chronic hyperplastic candidiosis (0.38%), and erythroplakia (0.096%). Smoking, alcohol, and age (>40 years) were the main identifiable risk factors. Patients with OPMDs displayed a general lack of awareness and negative attitudes towards early diagnosis and treatment. Conclusions: OPMDs among Arab dental patients are relatively uncommon and awareness about oral cancer among Jordanian dental patients is low. Interventions to improve public knowledge about oral cancer and attitudes toward early diagnosis and treatment are urgently indicated.

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“…5 This clinical definition is useful where routine biopsy is unavailable. All oral leukoplakia were photographed and colour slides of the lesions classified as leukoplakia were reviewed independently by an oral pathologist who agreed with the original clinical diagnosis in every case.…”

Section: Case Definition and Examinationmentioning

confidence: 99%

“…Four studies, 5 Adjusted for alcohol and smoking, matched for age (63 years), sex, date of diagnosis (63 months).- 6 Adjusted for education, occupation, cigarette smoking, in nonalcohol drinkers, matched for age (63 years) and gender.-7 Adjusted for age, sex, education, BMI (kg/m 2 ) pack years smoking and years of alcohol.- 8 Adjusted for age, smoking and Human Papilloma Virus.- 9 Adjusted for age sex, census division and smoking. including the present one, reported on betel quid without tobacco chewing in non-smokers, with varying control for other potential confounding factors.…”

Section: Systematic Review and Meta-analysismentioning

confidence: 99%

Betel quid not containing tobacco and oral leukoplakia: A report on a cross‐sectional study in Papua New Guinea and a meta‐analysis of current evidence

Thomas

Harris

Ness

et al. 2008

Intl Journal of Cancer

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Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does not contain tobacco. We conducted a casecontrol study nested in a cross-sectional study in Papua New Guinea and a systematic review of studies that included chewers of betel quid without tobacco. Our study recruited 1,670 adults. We recorded betel quid chewing and smoking. The prevalence of leukoplakia was 11.7%. In the nested case-control study of 197 cases and 1,282 controls, current betel chewing was associated with increased risk of leukoplakia with an adjusted odds ratio for current chewers of 3.8 (95% CI 1.7, 8.4) and in the heaviest chewers of 4.1 (95% CI 1.8, 9.1) compared to non-chewers. Current smoking was associated with an increased risk of leukoplakia with an adjusted odds ratio for current smokers of 6.4 (95% CI 4.1, 9.9) and amongst heaviest smokers of 9.8 (95% CI 5.9, 16.4) compared to non-smokers. The systematic review identified 5 studies examining risk of leukoplakia associated with betel quid chewing in populations where betel quid did not contain tobacco and that controlled for smoking. In studies that adjusted for smoking, the combined random effect odds ratio was 7.9 (95% CI 4.3, 14.6) in betel quid chewers. The results of this study and systematic review of similar studies provide evidence of the role of betel quid not containing tobacco and leukoplakia. ' 2008 Wiley-Liss, Inc.Key words: betel quid; smoking; oral leukoplakia; oral cancer; Papua New Guinea Melanesia has the highest incidence of oral cancer in the world 1 and it is the most common cancer in Papua New Guinea (PNG). Rates are also high in South Asia. 1 In these populations, oral cancer is related to smoking and betel quid use. We recently reported a case-control study and a systematic review of betel quid without tobacco and found an increased risk of oral cancer independent of smoking. 2 We report here studies of betel quid without tobacco and risk of oral leukoplakia.Oral leukoplakia is an asymptomatic, potentially precancerous lesion. In a 10-year follow-up study in India, oral leukoplakia preceded oral cancer in nearly 70% of cancer cases. 3 The association of risk factors with oral leukoplakia can offer insights into the causal pathway. Furthermore, investigations into the aetiology of oral leukoplakia may be less biased than cancer studies, as leukoplakia is asymptomatic and therefore unlikely to modify behaviour although recall of behaviour might be more related to time. Studies of oral leukoplakia show similar results for smoking and betel quid (that contains tobacco) to those of oral cancer in India 4 ; however, until recently there have been few studies of betel quid without tobacco and oral leukoplakia. We present here data from a previously unpublished study in PNG (where betel quid is tobacco free) and other recently published researc...

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International seminar on oral leukoplakia and associated lesions related to tobacco habits

Cited by 218 publications

References 0 publications

Prevalence and Correlation of Oral Lesions among Tobacco Smokers, Tobacco Chewers, Areca Nut and Alcohol Users

Prevalence and Correlation of Oral Lesions among Tobacco Smokers, Tobacco Chewers, Areca Nut and Alcohol Users

Oral Potentially Malignant Disorders among Dental Patients: a Pilot Study in Jordan

Betel quid not containing tobacco and oral leukoplakia: A report on a cross‐sectional study in Papua New Guinea and a meta‐analysis of current evidence

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