International rare donor panels: a review

Nance, Sandra; Scharberg, Erwin A.; Thornton, Nicole; Yahalom, Vered; Sareneva, Inna; Lomas‐Francis, Christine

doi:10.1111/vox.12357

Cited by 31 publications

(42 citation statements)

References 22 publications

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“…Iran has been a member of the International Society for Blood Transfusion (ISBT) working party on rare donors since 2010 . Recognition of blood donors with D‐‐ phenotype are reported to the working party in order to be added in the list of countries with D‐‐ phenotype donors.…”

Section: Discussionmentioning

confidence: 99%

First report of the rare RhCE‐depleted D‐‐phenotype in sixteen people of Iranian origin

2019

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Background and Objectives In transfusion medicine, it may be a challenge to acquire compatible blood for patients who have clinically important alloantibodies to high-prevalence antigens. The aim of this study was to study prevalence of rare D--phenotype in samples from patients and their relatives referred to the Immunohematology reference laboratory of the Iranian Blood Transfusion Organization and the detection and identification of the phenotype and associated antibodies, particularly in an antenatal setting. This is the first report of the cases evaluated by the IBTO and family studies of the D--proposita in Iran and possibly the first attempted comprehensive study in the current transfusion-related literatures. Materials and MethodsThis retrospective cross-sectional study was carried out on 6720 pregnant women and individuals with difficult positive pretransfusion testing referred for ABO/Rh(D) typing and antibody screening during a period of 8 years from 2008 to December 2016 in the Immunohematology Reference Laboratory of the Iranian Blood Transfusion Organization, Tehran, Iran.Results During 2008 to December 2016, 16 persons from ten families were detected to have rare D--phenotype. Anti-Rh17 and anti-c were identified in plasma of the 11 persons, including 10 females with a history of multiple unsuccessful pregnancy and the total number of 24 abortions and one male with history of blood transfusion vs. 5 individuals, including an unmarried single woman, 1 person with a history of first-time pregnancy and 3 persons with a history of multiple pregnancy, who showed no alloimmunization. Based on these collective findings, we interpreted these results as being confirmed as D--phenotype (0.23%).Conclusion Irrespective of Rh (D) group a serological antibody screening test is recommended to be required in a National prenatal testing guideline.Key words: Anti-Rh17 (anti-Hro), D--phenotype, haemolytic disease of the fetus and newborn.

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Section: Discussionmentioning

confidence: 99%

First report of the rare RhCE‐depleted D‐‐phenotype in sixteen people of Iranian origin

2019

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“…Moreover, in some programs, rare donors are exclusively determined by being negative for single HFAs, whereas in other programs, donors negative for a combination of several public (common) red cell antigens are also recognized as being rare. As a consequence, the definition of a 'rare donor' is widely different, as vividly demonstrated by the existent variety of national rare donor programs [9].…”

Section: Introductionmentioning

confidence: 99%

Low-Frequency Blood Group Antigens in Switzerland

Gassner

Degenhardt

Meyer

et al. 2018

Transfus Med Hemother

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Background: High-frequency blood group antigens (HFA) are present in >90% of the human population, according to some reports even in >99% of individuals. Therefore, patients lacking HFA may become challenging for transfusion support because compatible blood is hardly found, and if the patient carries alloantibodies, the cross-match will be positive with virtual every red cell unit tested. Methods: In this study, we applied high-throughput blood group SNP genotyping on >37,000 Swiss blood donors, intending to identify homozygous carriers of low-frequency blood group antigens (LFA). Results: 326 such individuals were identified and made available to transfusion specialists for future support of patients in need of rare blood products. Conclusion: Thorough comparison of minor allele frequencies using population genetics revealed heterogeneity of allele distributions among Swiss blood donors which may be explained by the topographical and cultural peculiarities of Switzerland. Moreover, geographically localized donor subpopulations are described which contain above-average numbers of individuals carrying rare blood group genotypes.

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“…Currently, the IRDP database consists of 8000 donors, and the information is available via Internet. In a recent review, the members of the Working Party have provided a list of the most challenging types to obtain for their country . Rh null type is recognized as the rarest in the world.…”

Section: Rare Donor and Rare Donor Programmesmentioning

confidence: 99%

Managing a rare donor programme: the immunohaematology laboratory perspective

Paccapelo

2017

ISBT Science Series

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Alloimmunization is a major complication of blood transfusion which occurs more frequently in patients who are chronically transfused. It causes serologic investigations and makes the selection of compatible blood difficult, expensive and time-consuming. Prompt availability of compatible units for patients with complex alloimmunization requires access to an inventory of extensively typed blood and to a database of rare donors. There are two key factors for rare donor provision. First, the routine programmes of red cell antigen typing in large cohorts of donors. Second, the ability to enrol healthy donors and patients negative for high-prevalence antigens as well as family members. The immunohaematology laboratory is a highly specialized unit in charge of identifying challenging antibodies. It uses multiple methods of analysis and a broad inventory of reagents and cells not easily available. The laboratory also finds compatible blood units for patients with complex alloimmunization and designs appropriate transfusion strategies for these patients often in cooperation with international programmes.

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International rare donor panels: a review

Cited by 31 publications

References 22 publications

First report of the rare RhCE‐depleted D‐‐phenotype in sixteen people of Iranian origin

First report of the rare RhCE‐depleted D‐‐phenotype in sixteen people of Iranian origin

Low-Frequency Blood Group Antigens in Switzerland

Managing a rare donor programme: the immunohaematology laboratory perspective

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