International Olympic Committee Consensus Statement: Molecular Basis of Connective Tissue and Muscle Injuries in Sport

Ljungqvist, Arne; Schwellnus, Martin; Bachl, Norbert; Collins, Malcolm; Cook, Jillianne Leigh; Khan, Karim M.; Maffulli, Nicola; Pitsiladis, Yannis; Riley, Graham P.; Golspink, Geoffrey; Venter, Deon J.; Derman, E W; Engebretsen, Lars; Volpi, Piero

doi:10.1016/j.csm.2007.10.007

Cited by 56 publications

(35 citation statements)

References 83 publications

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“…In 2008, the International Olympic Committee (IOC) published a consensus document on the importance of molecular mechanisms in connective tissue and skeletal muscle injury and healing 2. This document predicted an increase in the use of autologous growth factors, as it has indeed happened following that publication.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, PRP in an injectable form has been used for the management of common muscle,14 tendon15 and cartilage injuries 16. As predicted by the 2008 IOC consensus document on the molecular mechanisms in connective tissue and skeletal muscle injury and healing,2 there is significant anecdotal evidence that the use of PRP for treating musculoskeletal injuries has increased in recent times. Currently, PRP is not considered as a drug or a therapeutic substance, and so it does not have the usual regulatory requirements that would generally be needed for a substance used in regular clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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IOC consensus paper on the use of platelet-rich plasma in sports medicine

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IOC consensus paper on the use of platelet-rich plasma in sports medicine

et al. 2010

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“…Most importantly it is a tissue that is prone to traumatic insult either through lacerations e.g. in hand trauma (Elliot, 2002), or through rupture from sporting injuries (Ljungqvist, Schwellnus et al, 2008) with considerable financial implications to both healthcare provision and the manual workforce. With either of these major clinical problems the mainstay of treatment is surgical suture repair.…”

Section: Introductionmentioning

confidence: 99%

The cell biology of suturing tendons

et al. 2010

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Trauma by suturing tendon form areas devoid of cells termed “acellular zones” in the matrix. This study aimed to characterise the cellular insult of suturing and acellular zone formation in mouse tendon. Acellular zone formation was evaluated using single grasping sutures placed using flexor tendons with time lapse cell viability imaging for a period of 12 h. Both tension and injury were required to induce cell death and cell movement in the formation of the acellular zone. DNA fragmentation studies and transmission electron microscopy indicated that cells necrosed.Parallel in vivo studies showed that cell-to-cell contacts were disrupted following grasping by the suture in tensioned tendon. Without tension, cell death was lessened and cell-to-cell contacts remained intact. Quantitative immunohistochemistry and 3D cellular profile mapping of wound healing markers over a one year time course showed that acellular zones arise rapidly and showed no evidence of healing whilst the wound healing response occurred in the surrounding tissues. The acellular zones were also evident in a standard modified “Kessler” clinical repair. In conclusion, the suture repair of injured tendons produces acellular zones, which may potentially cause early tendon failure.

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“…Thus, an IOC Consensus Statement in 2008 advocated an improved understanding of the molecular basis of the effects of growth factors, to ensure the optimization of therapies using PRGF and minimise the potential risks to patients and athletes 62 .…”

Section: Chondral Injuriesmentioning

confidence: 99%

Autologous Growth Factors: A Biological Treatment in Sports Medicine

Leong

Benedict

Chew

2010

Proceedings of Singapore Healthcare

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Autologous growth factors have been used in maxillofacial and plastic surgery since the 1990s. The use of preparations rich in growth factors has seen an increase in sports medicine is due to its potential to enhance muscle, tendon, ligament and cartilage healing, and thereby accelerating an athlete's functional return to play. The efficacy of these autologous preparations rich in growth factors has seen varying healing effects for ligament, tendon, muscle, and cartilage injuries. Current clinical evidence is in its infancy with mainly animal and retrospective human studies, but the use of preparations rich in growth factors has increased, given its favourable safety profile and efficient preparation and delivery systems. It is important for physicians to keep abreast with the latest available preparation devices and current clinical evidence looking into the effects of autologous growth factors on tendon, ligament, muscle and cartilage healing.

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International Olympic Committee Consensus Statement: Molecular Basis of Connective Tissue and Muscle Injuries in Sport

Cited by 56 publications

References 83 publications

IOC consensus paper on the use of platelet-rich plasma in sports medicine

IOC consensus paper on the use of platelet-rich plasma in sports medicine

The cell biology of suturing tendons

Autologous Growth Factors: A Biological Treatment in Sports Medicine

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