International Meeting on Cancer Chemoprevention: molecular basis, mechanisms and trials

Bartsch, Holger; Frank, Natasha Y.; Gerhäuser, Clarissa; Owen, R. W.; Berger, Massimo

doi:10.1097/00008469-199702000-00013

Cited by 2 publications

(2 citation statements)

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“…In conjunction with efforts to combat cancer, increasing research emphasizes the importance of cancer prevention. Chemopreventive agents such as retinoids, barbital, genistein, and aspirin, along with the regulation of crucial cellular pathways like TGF, TNF, E2F, and Bcl-2, offer a novel approach to reducing cancer risk by halting the progression of precancerous cells and mitigating the effects of carcinogenic agents, showcasing the potential for targeted cancer prevention [36][37][38][39][40][41].…”

Section: Introductionmentioning

confidence: 99%

Cancer Initiation and Progression: A Comprehensive Review of Carcinogenic Substances, Anti-Cancer Therapies, and Regulatory Frameworks

Bhat,

Ahmed,

Abbas

et al. 2024

Asian J. Res. Biochem.

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Cancer is a multifaceted disease influenced by genetic mutations and environmental factors, including exposure to carcinogens. This review presents an in-depth analysis of the mechanisms driving cancer initiation, focusing on the roles of carcinogenic chemicals, anticancer therapies, and chemo-preventive agents. The discussion encompasses a broad spectrum of carcinogens: chemical agents like polycyclic aromatic hydrocarbons, physical agents such as ionizing radiation, biological agents like viruses, and certain therapeutic drugs. The multistep nature of carcinogenesis—comprising initiation, promotion, and progression phases—is detailed, with an emphasis on genetic and epigenetic alterations. Methods for testing carcinogenicity, including in vitro and in vivo studies and epidemiological approaches, are highlighted for their significance in identifying potential carcinogens and understanding their mechanisms. To classify and regulate carcinogenic exposures, the review also looks at the risk management plans and regulatory frameworks used by agencies like the European Chemicals Agency (ECHA), the Environmental Protection Agency (EPA), and the International Agency for Research on Cancer (IARC). Additionally, emerging trends in cancer treatment, such as precision oncology, immunotherapy, and early detection technologies, are explored, alongside ongoing challenges like health disparities and ethical issues. The review emphasizes the necessity of a multidisciplinary approach, involving collaboration among researchers, clinicians, regulatory bodies, and public health organizations, to translate scientific findings into effective cancer prevention, detection, and treatment strategies.

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Section: Introductionmentioning

confidence: 99%

Cancer Initiation and Progression: A Comprehensive Review of Carcinogenic Substances, Anti-Cancer Therapies, and Regulatory Frameworks

Bhat,

Ahmed,

Abbas

et al. 2024

Asian J. Res. Biochem.

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“…Furthermore, many of the new chalcone-based drugs are passing through pre-clinical trials to develop antimalarial [2] [3] and antileishmanial drugs [4]. Various substituted chalcones possess antioxidant [5], radical-scavenging [6], anticancer [7] [8], antileishmanial [9], antimalarial [10] [11], cytotoxic [12], antimitotic [13] [14], and antibacterial [15] properties, as well as P-glycoprotein mediated multidrug resistance [16]. We have recently reported the synthesis of some chalcones and benzothiazepines as free-radical scavengers and enzyme inhibitors of cholinesterases, urease, and a-glucosidase [17].…”

mentioning

confidence: 99%

Combinatorial Synthesis and Antibacterial Evaluation of an Indexed Chalcone Library

Ansari¹,

Nazir²,

Noureen³

et al. 2005

C&B

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A 120-membered chalcone library has been designed and prepared from six differently substituted acetophenones (A1-A6) and 20 benzaldehydes (B1-B20). The library was subjected to biological studies targeted against six bacterial strains. For the identification of the most-active member(s) of the library, the so-called indexed or positional-scanning method was applied. Six out of 26 sub-libraries, i.e., AL1-AL6, were synthesized by keeping the acetophenone moiety A fixed and using equimolar quantities of the 20 different benzaldehydes. The remaining 20 sub-libraries BL1-BL20 were prepared by keeping the benzaldehyde B component fixed and varying the six acetophenones (Table 1). The bactericidal activities of the resulting sub-libraries were tested and used as indices to the rows or columns of a two-dimensional matrix. Finally, parallel synthesis of 24 specific members with the highest-expected antibacterial activities, present in two sub-libraries, was carried out. These chalcones were screened again, and the results were exploited for establishing the structure-activity relationship (SAR) and the identification of the lead compound, which turned out to be 1,3-bis(2-hydroxyphenyl)prop-2-en-1-one (A2B2) in terms of activity towards Staphylococcus aureus and Bacillus subtilis (Tables 5-7).

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International Meeting on Cancer Chemoprevention: molecular basis, mechanisms and trials

Cited by 2 publications

References 0 publications

Cancer Initiation and Progression: A Comprehensive Review of Carcinogenic Substances, Anti-Cancer Therapies, and Regulatory Frameworks

Cancer Initiation and Progression: A Comprehensive Review of Carcinogenic Substances, Anti-Cancer Therapies, and Regulatory Frameworks

Combinatorial Synthesis and Antibacterial Evaluation of an Indexed Chalcone Library

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