International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways

Hung, Rayjean J.; Christiani, David C.; Risch, Angela; Popanda, Odilia; Haugen, Aage; Zienolddiny, Shanbeh; Benhamou, Simone; Bouchardy, Christine; Lan, Qing; Spitz, Margaret R.; Wichmann, H. E.; LeMarchand, Loïc; Víneis, Paolo; Matullo, Giuseppe; Kiyohara, Chikako; Zhang, Zuo‐Feng; Pezeshki, Benhnaz; Harris, Curtis C.; Mechanic, Leah E.; Seow, Adeline; Ng, Daniel; Szeszenia-Da̧browska, Neonila; Заридзе, Давид; Lissowska, Jolanta; Rudnai, Péter; Fabiánovà, Eleonóra; Mateș, Dana; Foretová, Lenka; Janout, Vladimí­r; Bencko, Vladimír; Caporaso, Neil E.; Chen, Chu; Duell, Eric J.; Goodman, Gary E.; Field, John K.; Houlston, Richard S.; Hong, Yun Chul; Landi, Maria Teresa; Lazarus, Philip; Muscat, Joshua E.; McLaughlin, John; Schwartz, Ann G.; Shen, Hongbing; Stücker, Isabelle; Tajima, Kazuo; Matsuo, Keitaro; Thun, Michael J.; Yang, Ping; Wiencke, John K.; Andrew, Angeline S.; Monnier, Stéphanie; Boffetta, Paolo; Brennan, Paul

doi:10.1158/1055-9965.epi-08-0411

Cited by 91 publications

(91 citation statements)

References 32 publications

(24 reference statements)

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“…Through literature search and selection based on the inclusion criteria, 39 studies were found, but only 22 studies met our inclusion criteria, as listed in Table 1. Seventeen studies were excluded for the following reasons: five studies did not contain exact genotype distribution information; (17)(18)(19)(20)(21) four studies were reviews; (22)(23)(24)(25) four studies were not case-control studies; (26)(27)(28)(29) and in three studies, (30)(31)(32) genotype distributions in control population deviated from the Hardy-Weinberg equilibrium. Furthermore, one study of bladder cancer (33) in which the variant allele frequency was extremely lower than expected, which may reflect wrong allele counting or poor genotyping quality, was also excluded from our meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: A meta‐analysis

et al. 2010

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Several studies have investigated the associations between X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism and the susceptibility to lung cancer and bladder cancer, but results have been inconclusive. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 22 case control studies, including 2976 cases and 4495 controls for lung cancer, and 3445 cases and 4599 controls for bladder cancer, met the inclusion criteria and were selected. Overall, there was no evidence showing a significant association between XRCC3 Thr241Met polymorphism and lung cancer risk. Furthermore, the results for bladder cancer showed that significant decreased risk was found for the additive model (odds ratio [OR] = 0.959, 95% confidence interval [CI], 0.924-0.996) and dominant model (OR = 0.982, 95% CI, 0.963-1.000) but not for the recessive model (OR = 0.958, 95% CI, 0.905-1.014). In summary, our meta-analysis indicates that XRCC3 Thr241Met polymorphism may be weakly associated with the risk of bladder cancer. (Cancer Sci 2010; 101: 1777-1782 L ung cancer is one of the most common cancers worldwide, and it is the leading cause of cancer-related deaths in the world.(1) The role of genetic susceptibility in lung cancer has shown that the relatives of patients with lung cancer had an increased risk of the disease.(1,2) Only a fraction of smokers and a low number of non-smokers develop lung cancer, which implies influence of host factors in individual susceptibility. This inter-individual difference in susceptibility may be attributed to genetic polymorphisms in critical genes, including those involved in DNA repair. (3,4) Bladder cancer is among the most frequent diagnosed cancer in the developed world.(5) Although development of bladder cancer is associated with exposure to tobacco and occupational exposure, (6) only a small proportion of exposed individuals will develop cancer, suggesting the involvement of genetic factors.DNA repair systems play an critical role in maintaining genomic integrity.(3) If DNA damage is unrepaired, mutations are propagated during subsequent cellular replication and ultimately result in activation of oncogenes or inactivation of tumor suppressor genes. So mutations on these genes which alter the function of these proteins may predispose an individual to cancer. Increasing molecular epidemiologic evidence has shown that polymorphisms in various DNA repair genes are associated with an increased risk of cancer. (7,8) The X-ray repair cross-complementing group 3 (XRCC3) belongs to a family of genes responsible for repairing DNA double strand breaks caused by normal metabolic processes and ⁄ or exposure to ionizing radiation. The XRCC3 is involved in homologous recombination repair (HRR) and chromosomal double-strand breaks repair processes, and it is necessary to maintain genomic integrity. It was demonstrated that cell lines defective in XRCC3 had a 25-fold decrease in homology directed repair of DNA double-strand breaks.(9) Shen et al.ide...

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Section: Resultsmentioning

confidence: 99%

XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: A meta‐analysis

et al. 2010

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“…Four publications were excluded because of meta-analysis, control group had cancer patients or not published in English. Finally, 26 full-text articles with eligibility were included in this meta-analysis (Smith et al, 2003;Huang et al, 2006;Mechanic et al, 2006;Moreno et al, 2006;Crew et al, 2007;Jorgensen et al, 2007;Chang et al, 2008;Hung et al, 2008;McWilliams et al, 2008;Rajaraman et al, 2008;Abbasi et al, 2009;Han et al, 2009;Joshi et al, 2009;Agalliu et al, 2010;Rajaraman et al, 2010;Doherty et al, 2011;Krupa et al, 2011;Smith et al, 2011;Gil et al, 2012;Yu et al, 2012;Cheng et al, 2013;Santos et al, 2013;Wang et al, 2013;Wyss et al, 2013;Kohlhase et al, 2014;Steck et al, 2014). The flow chart which reflected the details of article selection was presented in Figure 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

Associations of ERCC4 rs1800067 Polymorphism with Cancer Risk: an Updated Meta-analysis

Yuan

Liu²,

Xing³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Activity in the repair of 8-hydroxyguanine is greater with the hOGG1-Ser326 protein than the hOGG1-Cys326 protein, 5 and the possible contribution of this locus to the risk of a variety of human cancers has been reported. 6 A number of studies [7][8][9][10][11][12][13][14] and systematic approaches [15][16][17] have examined the role of the Ser326Cys polymorphism in lung cancer susceptibility. One meta-analysis showed that the overall odds ratio (OR) of homozygotes for the hOGG1-326Cys allele against those for the hOGG1-326Ser allele was 1.24 (95% confidence interval (CI)¼1.01-1.53), suggesting that the locus is involved in susceptibility to overall lung cancer.…”

Section: Introductionmentioning

confidence: 99%

“…15 A recent pooled analysis from the International Lung Cancer Consortium involving a substantial number of cases and controls showed a suggestive association for this polymorphism in Caucasians. 16 One question that remains unanswered is whether the impact of rs1052133 differs according to histological subtype of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type

et al. 2009

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Human 8-oxoguanine DNA glycosylase 1 (hOGG1) has a major role in the repair of 8-hydroxyguanine, a major promutagenic DNA lesion. The genetic polymorphism rs1052133, which leads to substitution of the amino acid at codon 326 from Ser to Cys, shows functional differences, namely a decrease in enzyme activity in hOGG1-Cys326. Although several studies have investigated the association between rs1052133 and lung cancer susceptibility, the effect of this locus on lung cancer according to histology remains unclear. We therefore conducted a case-control study with 515 incident lung cancer cases and 1030 age-and sex-matched controls without cancer, and further conducted a meta-analysis. In overall analysis, the homozygous Cys/Cys genotype showed a significant association with lung cancer compared to Ser allele carrier status (odds ratio (OR)¼1.31, 95% confidence interval (CI)¼1.02-1.69). By histology-based analysis, the Cys/Cys genotype showed a significantly positive association with small-cell carcinoma (OR¼2.40, 95% CI¼1.32-4.49) and marginally significant association with adenocarcinoma (OR¼1.32, 95% CI¼0.98-1.77). A meta-analysis of previous and our present study revealed that this polymorphism is positively associated with adenocarcinoma, although suggestive associations were also found for squamousand small-cell lung cancers. These results indicate that rs1052133 contributes to the risk of adenocarcinoma of lung.

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International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways

Cited by 91 publications

References 32 publications

XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: A meta‐analysis

XRCC3 Thr241Met polymorphism with lung cancer and bladder cancer: A meta‐analysis

Associations of ERCC4 rs1800067 Polymorphism with Cancer Risk: an Updated Meta-analysis

hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type

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