International inter-comparison exercise on $${}^{153}\hbox {Sm}$$

Jackson, Mark J.; Gilligan, Chris; Davies, A. V.; Britton, R.; Friese, Judah I.; Greenwood, L.R.; Pierson, Bruce D.; Finch, Zach; Gartman, Brandy N.; Dry, D. E.; May, Iain; Smythe, Nathan C.; Gaunt, Andrew J.; Thomas, Ed; Roberts, Kevin E.; Harward, N.; Thomas, Keenan; Woody, P. T.; Zhao, Pihong

doi:10.1007/s10967-018-6048-1

Cited by 7 publications

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the calculations performed in this study we also do not consider the self absorption (Cho et al 1999, Rivard et al 2017 or dose enhancement (Ngwa et al 2012, 2013, Martinov et al 2017, Sinha et al 2015 by material of NPs. However, the radionuclides: Pd-103, Sm-153 and Au-198 along with electrons emit photons of energy 20.6 keV (average) (Lechtman et al 2011), 103 keV (28%) (Jackson et al 2018) and 411keV (93%) (Moreira et al 2010). These emitted photons/electrons on interaction with material of NPs, Au, can result in radiosensitization/self absorption.…”

Section: Surviving Fraction and Tumor Volumementioning

confidence: 99%

In silico dosimetry of low-dose rate brachytherapy using radioactive nanoparticles

et al. 2021

View full text Add to dashboard Cite

Purpose. Nanoparticles (NPs) with radioactive atoms incorporated within the structure of the NP or bound to its surface, functionalized with biomolecules are reported as an alternative to low-dose-rate seed-based brachytherapy. In this study, authors report a mathematical dosimetric study on low-dose rate brachytherapy using radioactive NPs. Method. Single-cell dosimetry was performed by calculating cellular S-values for spherical cell model using Au-198, Pd-103 and Sm-153 NPs. The cell survival and tumor volume versus time curves were calculated and compared to the experimental studies on radiotherapeutic efficiency of radioactive NPs published in the literature. Finally, the radiotherapeutic efficiency of Au-198, Pd-103 and Sm-153 NPs was tested for variable: administered radioactivity, tumor volume and tumor cell type. Result. At the cellular level Sm-153 presented the highest S-value, followed by Pd-103 and Au-198. The calculated cell survival and tumor volume curves match very well with the published experimental results. It was found that Au-198 and Sm-153 can effectively treat highly aggressive, large tumor volumes with low radioactivity. Conclusion. The accurate knowledge of uptake rate, washout rate of NPs, radio-sensitivity and tumor repopulation rate is important for the calculation of cell survival curves. Self-absorption of emitted radiation and dose enhancement due to AuNPs must be considered in the calculations. Selection of radionuclide for radioactive NP must consider size of tumor, repopulation rate and radiosensitivity of tumor cells. Au-198 NPs functionalized with Mangiferin are a suitable choice for treating large, radioresistant and rapidly growing tumors.

show abstract