International incidence of oropharyngeal cancer: A population-based study

Cancela, Marianna de Camargo; Souza, Dyego Leandro Bezerra de; Curado, María Paula

doi:10.1016/j.oraloncology.2011.12.013

Cited by 42 publications

(35 citation statements)

References 29 publications

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“…Accordingly, some studies have reported that the tumor site is related to specific risk factors (5,6,15,18,(30)(31)(32). Tumors of the tongue and the floor of the mouth may be associated with excessive alcohol consumption and cigarette-smoking habits (1,6,29,32), whereas lesions on the buccal mucosa and gingiva may be related to tobacco/betel quid chewing habits (1,6,18,30). Taken together, these factors could explain the low percentages of tumors on the gingiva and buccal mucosa in the young group in our study.…”

Section: Discussionmentioning

confidence: 99%

Ten-year analysis of oral cancer focusing on young people in northern Thailand

et al. 2015

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The objective of the present study was to assess the current situation of oral squamous cell carcinoma (OSCC) in northern Thailand, with an emphasis on patients <40 years of age. Medical records of patients histologically diagnosed with OSCC were collected from the Cancer Registry of Maharaj Nakorn Chiang Mai Hospital, Thailand between 2001 and 2010. The clinico-demographic data of patients aged <40 years (young group) and those aged ≥40 years (old group) were compared. A total of 874 patients were included in this study, of which 4.1% were <40 years of age. The tongue was the most common cancer site in both age groups. Most patients in both age groups were diagnosed with oral cancer at stage IV. Tobacco smoking (62.3%) and alcohol consumption (52.3%) were the most common risk factors in both age groups. However, the rates of betel quid chewing (17.5%) had decreased from those found in our study in the previous decade (50.2%); these rates were not found in the young group. The 5-year survival rate was 27.4% for the old group and 56.2% for the young group. OSCC remains a serious oral health problem in northern Thailand, and it has not been resolved among young adults. (J Oral Sci 57, 327-334, 2015)

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Section: Discussionmentioning

confidence: 99%

Ten-year analysis of oral cancer focusing on young people in northern Thailand

et al. 2015

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“…This may be of importance for the treatment of OSCC, where tonsillar squamous cell carcinoma (TSCC) and base of tongue squamous carcinoma (BOTSCC) dominate[5], since HPV DNA + tumors have a much better clinical outcome than those that are HPV DNA negative (HPV DNA -)[6,7]. More specifically, patients with HPV DNA + tumors have roughly an 80% 5-year disease-specific survival, compared those with HPV DNA - tumors, where survival (40%) is similar to that observed in patients with other head and neck squamous cell carcinomas (HNSCC) of similar stages[6,8].…”

Section: Introductionmentioning

confidence: 99%

HLA Class I and II Expression in Oropharyngeal Squamous Cell Carcinoma in Relation to Tumor HPV Status and Clinical Outcome

et al. 2013

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HPV-DNA positive (HPVDNA+) oropharyngeal squamous cell carcinoma (OSCC) has better clinical outcome than HPV-DNA negative (HPVDNA-) OSCC. Current treatment may be unnecessarily extensive for most HPV+ OSCC, but before de-escalation, additional markers are needed together with HPV status to better predict treatment response. Here the influence of HLA class I/HLA class II expression was explored. Pre-treatment biopsies, from 439/484 OSCC patients diagnosed 2000-2009 and treated curatively, were analyzed for HLA I and II expression, p16INK4a and HPV DNA. Absent/weak as compared to high HLA class I intensity correlated to a very favorable disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS) in HPVDNA+ OSCC, both in univariate and multivariate analysis, while HLA class II had no impact. Notably, HPVDNA+ OSCC with absent/weak HLA class I responded equally well when treated with induction-chemo-radiotherapy (CRT) or radiotherapy (RT) alone. In patients with HPVDNA- OSCC, high HLA class I/class II expression correlated in general to a better clinical outcome. p16INK4a overexpression correlated to a better clinical outcome in HPVDNA+ OSCC. Absence of HLA class I intensity in HPVDNA+ OSCC suggests a very high survival independent of treatment and could possibly be used clinically to select patients for randomized trials de-escalating therapy.

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“…Pakistan has one of the highest prevalence of oral cancer in the world [2]. With an age-standardized incidence rate of 9.8/100,000, oral cancer has become the most frequent cancer among males and the second most common cancer among both sexes in Pakistan [1].…”

Section: Introductionmentioning

confidence: 99%

Oral cancer via the bargain bin: The risk of oral cancer associated with a smokeless tobacco product (Naswar)

et al. 2017

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In the wake of smokeless tobacco (SLT) being advocated as a mean of tobacco harm reduction, it is pertinent to establish individual health risks associated with each SLT product. This case-control study was aimed at assessing the risk of oral cancer associated with a smokeless tobacco product (Naswar). The study was conducted from September 2014 till May 2015 in Khyber Pakhtunkhwa, Pakistan. Exposure and covariate information was collected through a structured questionnaire. Conditional logistic regression was used to calculate odds ratios (OR) along with their 95% confidence intervals (CI). 84 oral cancer cases (62% males) and 174 age- and sex-matched controls were recruited. Ever users of Naswar had more than a 20-fold higher risk of oral cancer compared to never-users (OR 21.2, 95% CI 8.4–53.8). Females had a higher risk of oral cancer with the use of Naswar (OR 29.0, 95% CI 5.4–153.9) as compared to males (OR 21.0, 95% CI 6.1–72.1). Based on this result, 68% (men) and 38% (women) of the oral cancer burden in Pakistan is attributable to Naswar. The risk estimates observed in this study are comparable to risk estimates reported by previous studies on other forms of SLT use and the risk of oral cancer in Pakistan. The exposure-response relationship also supports a strong role of Naswar in the etiology of oral cancer in Pakistan. Although still requiring further validation through independent studies, these findings may be used for smokeless tobacco control in countries where Naswar use is common.

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International incidence of oropharyngeal cancer: A population-based study

Cited by 42 publications

References 29 publications

Ten-year analysis of oral cancer focusing on young people in northern Thailand

Ten-year analysis of oral cancer focusing on young people in northern Thailand

HLA Class I and II Expression in Oropharyngeal Squamous Cell Carcinoma in Relation to Tumor HPV Status and Clinical Outcome

Oral cancer via the bargain bin: The risk of oral cancer associated with a smokeless tobacco product (Naswar)

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