International equine gene mapping workshop report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources

Penedo, M. C. T.; Millon, L. V.; Bernoco, D.; Bailey, Ernest; Binns, M. M.; Cholewiński, Grzegorz; Ellis, Noel; Flynn, Jullien M; Gralak, B.; Guthrie, Alan John; Hasegawa, Telhisa; Lindgren, Gabriella; Lyons, Leslie A.; Røed, Knut; Swinburne, June; Tozaki, Teruaki

doi:10.1159/000085664

Cited by 63 publications

(62 citation statements)

References 48 publications

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“…The former whole genome scan was performed with relative marker positions in cM taken from Swinburne et al (2006) and Penedo et al (2005). The release of the horse genome has made it possible to verify the QTL on the horse genome assembly (EquCab2) (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Refinement of a quantitative gene locus on equine chromosome 16 responsible for osteochondrosis in Hanoverian warmblood horses

Lampe¹,

Dierks²,

Distl³

2009

Animal

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Osteochondrosis (OC) is an inherited developmental disease in young horses most frequently observed in thoroughbreds, trotters, warmblood and coldblood horses. Quantitative trait loci (QTL) for equine OC have been identified in Hanoverian warmblood horses employing a whole genome scan with microsatellites. A QTL on ECA16 reached the genome-wide significance level for hock osteochondrosis dissecans (OCD). The aim of this study was to refine this QTL on ECA16 using an extended marker set of 34 newly developed microsatellites and 15 single nucleotide polymorphisms (SNPs). We used the same 14 paternal half-sib groups as in the above-mentioned whole genome scan. The QTL for OCD in hock joints on ECA16 could be delimited at an interval between 17.60 and 45.18 Mb using multipoint non-parametric linkage analyses. In addition, six microsatellites and one SNP were significantly associated with hock OCD in the QTL region between 24.26 and 42.41 Mb. Furthermore, our analysis revealed a second QTL for fetlock OC between 6.55 and 24.26 Mb on ECA16. This report is a further step towards unravelling the genes underlying QTL for equine OC and towards the development of a marker test for OC in Hanoverian warmblood horses.

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Section: Resultsmentioning

confidence: 99%

Refinement of a quantitative gene locus on equine chromosome 16 responsible for osteochondrosis in Hanoverian warmblood horses

Lampe¹,

Dierks²,

Distl³

2009

Animal

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“…It is known that the recessive e gene increases the amount of white markings (Woolf 1992). Considering the low frequency of the e allele in Hucul population and the linkage between the MC1R and KIT loci (Penedo et al 2005), there would be little probability of a chestnut crypto-tobiano Hucul. Hence, at least in the case of the crypto-tobianos found in the study, the white patches could not have been increased by the e allele activity.…”

Section: Discussionmentioning

confidence: 99%

Crypto-tobiano horses in Hucul breed

Stachurska¹,

Jansen²

2015

Czech J. Anim. Sci.

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ABSTRACT:The aim of the study was to verify the hypothesis that the crypto-tobiano horses which do not exhibit the full tobiano white-spotting pattern nonetheless transmit the dominant To gene to the progeny. The study was conducted on the Hucul population. Seven horses with white patches on their limbs, and with or without a small patch on the head, neck or trunk, were selected. At least one of the parents of the horses had to be tobiano or crypto-tobiano. Occasionally such horses produced a tobiano foal from a crossing with a solidcoloured horse. The white patches of the horses used in our study were divided into categories. To identify the To gene, DNA was tested in the Animal Genetics Laboratory (UK). The ratio of non-tobiano, crypto-tobiano, and tobiano foals born from 36 matings of the studied horses was analyzed. The study substantiates the occurrence of crypto-tobiano horses in the Hucul breed. Horses that have patches on their limbs as well as a small white or intermingled patch on the head, neck or trunk, are crypto-tobianos, although crypto-tobianos may have no white on the head, neck, and trunk. The crypto-tobiano pattern occurs in horses which have a tobiano parent or grandparent. The results suggest that the activity of an inhibitor gene suppresses the To allele penetrance in the crypto-tobiano horses. As in the case of many white-spotting patterns, the presence of the To gene in a horse's genotype should be documented by DNA testing or test matings.

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“…The fact can be attributed to easy allowance of chestnut mares to the breeding and may be connected with the rising tobiano horse occurrence. The linked MC1R and KIT loci are separated by only 20-34 cM, hence the crossing over in that region may occur not often (Penedo et al, 2005). Theoretically, e.g.…”

Section: Discussionmentioning

confidence: 99%

Allele frequency in loci which control coat colours in Hucul horse population

Stachurska¹,

Brodacki²,

Grabowska³

2012

CZECH J ANIM SCI

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The objective of the study was to determine the frequency of alleles which produce coat colours in Hucul horse population in Poland. The breed is included in the Global Strategy for Management of Farm Animal Genetic Resources, hence its gene pool should remain in unaltered state. Huculs are bay, black, blue dun, yellow dun, tobiano, and chestnut. Grey and chestnut Huculs have always been undesirable. The material consisted of all 1022 matings which resulted in subpopulations recorded in Studbook volumes. The recessive allele frequency was estimated as the square root of recessive genotype frequencies in ASIP (A), MC1R (E), DUN (D), KIT (To region), and STX17 (G) loci. The frequency in A and E loci in total parental generation was also estimated in test matings. Genotype distribution in the population was anticipated according to gamete frequency in sires and dams. Small Wahlund effect, F<sub>ST</sub>and χ<sup>2</sup> values for allele distributions show that division into subpopulations did not influence the population genetic structure significantly. Mean recessive allele frequency in A, E, D, To, and G loci amounted to 0.521, 0.115, 0.878, 0.929, and 0.997, respectively, and in A and E loci it was similar to that assessed in test matings. More bay horses and fewer D diluted horses appeared in offspring than expected. A, e, d, and To allele frequency showed a rising tendency. The genetic structure in Hucul population is not constant and does not comply strictly with the preservation aim. Bay, non-diluted, and tobiano horses are preferred. The linkage between MC1R and KIT loci can make the selection against e allele difficult. Breeders’ preferences may lead to undesired changes in the allele frequency. To avoid such risk, it is recommended to select horses strictly complying with the rules included in the breeding programme and mate the horses randomly from this aspect.  

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International equine gene mapping workshop report: a comprehensive linkage map constructed with data from new markers and by merging four mapping resources

Cited by 63 publications

References 48 publications

Refinement of a quantitative gene locus on equine chromosome 16 responsible for osteochondrosis in Hanoverian warmblood horses

Refinement of a quantitative gene locus on equine chromosome 16 responsible for osteochondrosis in Hanoverian warmblood horses

Crypto-tobiano horses in Hucul breed

Allele frequency in loci which control coat colours in Hucul horse population

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