International cooperation for kidney exchange success

Valentín, María O.; Martínez, Marta García; Costa, Alessandro Nanni; Bolotinha, Catarina; Guirado, Lluís; Vistoli, Fabio; Breda, Alberto; Fiaschetti, P.; Domínguez‐Gil, Beatriz

doi:10.1097/00007890-900000000-96204

Cited by 5 publications

(7 citation statements)

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“…Our cooperation, which has led to the first cross-border LD kidney exchange in Europe [18], may be a starting point for the set-up of new larger-scale trans-national initiatives. So far, only few examples of cross-border shipping of KPD kidneys have been reported, one exchange between the United States and Canada [21], and, another between Spain and Italy [22]. The primary rationale behind merging our small programs was to increase KPD pool size, a critical determinant of match probability [4,5,13].…”

Section: Discussionmentioning

confidence: 99%

Crossing borders to facilitate live donor kidney transplantation: the Czech‐Austrian kidney paired donation program – a retrospective study

et al. 2020

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Kidney paired donation (KPD) is a valuable tool to overcome immunological barriers in living donor transplantation. While small national registries encounter difficulties in finding compatible matches, multinational KPD may be a useful strategy to facilitate transplantation. The Czech (Prague) and Austrian (Vienna) KPD programs, both initiated in 2011, were merged in 2015. A bi-national algorithm allowed for ABO-and low-level HLA antibody-incompatible exchanges, including the option of altruistic donorinitiated domino chains. Between 2011 and 2019, 222 recipients and their incompatible donors were registered. Of those, 95.7% (Prague) and 67.9% (Vienna) entered into KPD registries, and 81 patients received a transplant (95% 3-year graft survival). Inclusion of ABO-incompatible pairs in the Czech program contributed to higher KPD transplant rates (42.6% vs. 23.6% in Austria). After 2015 (11 bi-national match runs), the median pool size increased to 18 pairs, yielding 33 transplants (8 via cross-border exchanges). While matching rates doubled in Austria (from 9.1% to 18.8%), rates decreased in the Czech program, partly due to implementation of more stringent HLA antibody thresholds. Our results demonstrate the feasibility of merging small national KPD programs to increase pool sizes and may encourage the implementation of multinational registries to expand the full potential of KPD.

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Section: Discussionmentioning

confidence: 99%

Crossing borders to facilitate live donor kidney transplantation: the Czech‐Austrian kidney paired donation program – a retrospective study

et al. 2020

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“…Nowadays, several countries are starting an international Kidney Exchange Programme (IKEP) by merging the pools of their national KEPs; for example, Austria with the Czech Republic [12]; Denmark with Norway and Sweden; and Italy with Portugal and Spain [37]. This may lead to more patients being helped.…”

Section: An Application Of Partitioned Matching Gamesmentioning

confidence: 99%

“…The other one, the class of partitioned matching games, is a new class of cooperative games introduced in this paper. We show how these two generalizations are related to each other and justify the new class of cooperative games by an emerging real-world application: international kidney exchange [12,37]. Partitioned matching games implicitly played a role in international kidney exchange through the work of [7,23] and have recently been used as a basis for simulations in [6].…”

Section: Introductionmentioning

confidence: 99%

Partitioned Matching Games for International Kidney Exchange

Benedek¹,

Bíró²,

Kern³

et al. 2023

Preprint

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We introduce partitioned matching games as a suitable model for international kidney exchange programmes, where in each round the total number of available kidney transplants needs to be distributed amongst the participating countries in a "fair" way. A partitioned matching game (N, v) is defined on a graph G = (V, E) with an edge weighting w and a partition V = V1 ∪ • • • ∪ Vn. The player set is N = {1, . . . , n}, and player p ∈ N owns the vertices in Vp. The value v(S) of a coalition S ⊆ N is the maximum weight of a matching in the subgraph of G induced by the vertices owned by the players in S. If |Vp| = 1 for all p ∈ N , then we obtain the classical matching game. Let c = max{|Vp| | 1 ≤ p ≤ n} be the width of (N, v). We prove that checking core non-emptiness is polynomial-time solvable if c ≤ 2 but co-NP-hard if c ≤ 3. We do this via pinpointing a relationship with the known class of b-matching games and completing the complexity classification on testing core nonemptiness for b-matching games. With respect to our application, we prove a number of complexity results on choosing, out of possibly many optimal solutions, one that leads to a kidney transplant distribution that is as close as possible to some prescribed fair distribution.

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“…Chains initiated by deceased donors 21,22 increase the interaction between deceased and kidney exchange systems. Furthermore, with increasing transnational collaboration on KEPs, 23,24 the above-mentioned concerns should also be considered and addressed. It is possible to enter some data (such as HLA typing) directly from diagnostic equipment, and if such features are available it is important to verify that the equipment and the database can communicate.…”

Section: Consensus On Minimum Datasetsmentioning

confidence: 99%

Data and optimisation requirements for Kidney Exchange Programs

Smeulders

Pettersson

Viana

et al. 2021

Health Informatics J

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Kidney Exchange Programs (KEP) are valuable tools to increase the options of living donor kidney transplantation for patients with end-stage kidney disease with an immunologically incompatible live donor. Maximising the benefits of a KEP requires an information system to manage data and to optimise transplants. The data input specifications of the systems that relate to key information on blood group and Human Leukocyte Antigen (HLA) types and HLA antibodies are crucial in order to maximise the number of identified matched pairs while minimising the risk of match failures due to unanticipated positive crossmatches. Based on a survey of eight national and one transnational kidney exchange program, we discuss data requirements for running a KEP. We note large variations in the data recorded by different KEPs, reflecting varying medical practices. Furthermore, we describe how the information system supports decision making throughout these kidney exchange programs.

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International cooperation for kidney exchange success

Cited by 5 publications

References 0 publications

Crossing borders to facilitate live donor kidney transplantation: the Czech‐Austrian kidney paired donation program – a retrospective study

Crossing borders to facilitate live donor kidney transplantation: the Czech‐Austrian kidney paired donation program – a retrospective study

Partitioned Matching Games for International Kidney Exchange

Data and optimisation requirements for Kidney Exchange Programs

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