International Clinical Guidelines for the Adoption of Digital Pathology: A Review of Technical Aspects

García-Rojo, Marcial

doi:10.1159/000441192

Cited by 50 publications

(66 citation statements)

References 32 publications

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“…Recently, primary diagnosis on computer monitor screens using digitalized pathologic images has been practically approved by the Food and Drug Administrations (FDA) of the United States of America, the European Union, and Japan [13][14][15]. Dozens of validation studies have compared the diagnostic accuracy of DP and conventional microscopic diagnosis during the last decade [5,16].…”

Section: Application Of Digital Pathologymentioning

confidence: 99%

“…Telepathology has evolved so that DP data can be easily used, shared, and exchanged on various systems and devices using cloud systems. Because of this ubiquitous accessibility, network security and deidentification of personal information have never been more important [13].…”

Section: Application Of Digital Pathologymentioning

confidence: 99%

“…WSI scanners differ with respect to their functionality and features, and most image viewers are provided by scanner vendors [4]. When selecting a WSI scanner for clinical diagnosis, it is important to consider the following factors: (1) volume of slides, (2) type of specimen (eg, tissue section slides, cytology slides, or hematopathology smears), (3) feasibility of z-stack scanning (focus stacking), (4) laboratory needs for oil-immersion scanning, (5) laboratory needs for both bright field and fluorescence scanning, (6) type of glass slides (e.g., wet slides, unusual size), (7) slide barcode readability, (8) existing space constraints in the laboratory, (9) functionality of image viewer and management system provided by vendor, (10) bidirectional integration with existing information systems, (11) communication protocol (e.g., XML, HL7) between DPS and LIS, (12) whether image viewer software is installed on the server or on the local hard disk of each client workstation, (13) whether the viewer works on mobile devices, and (14) open or closed system.…”

Section: Implementation Of Digital Pathology System For Clinical Diagmentioning

confidence: 99%

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Introduction to digital pathology and computer-aided pathology

Nam

Chong

Jung

et al. 2020

J Pathol Transl Med

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/ by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. pISSN 2383-7837 eISSN 2383-7845Digital pathology (DP) is now one of the biggest issues facing the field of pathology. DP is a remarkable innovation that changes the paradigm of microscope-based pathology, which has existed for over 100 years. DP alters the way diagnostic tools represent pathologic images from the microscope to the computer screen and has changed storage media from glass slides to digitalized image files. Digitalized pathologic images stored in computer servers or cloud systems can be transmitted over the Internet, thus changing the temporal and spatial domain of pathologic diagnosis. In addition, machine learning allows software assisting in diagnosis to be developed and applied more actively and effectively.This review describes various concepts related to DP and computer-aided pathologic diagnosis (CAPD), current applications of DP, and various issues related to the implementation of DP. It also briefly introduces the development of computer-aided diagnostic tools and their limitations. DIGITAL PATHOLOGY AND COMPUTER-AIDED PATHOLOGYDP, which initially delineated the process of digitizing whole slide images (WSIs) using advanced slide scanning technology, is now a generic term that includes artificial intelligence (AI)based approaches for detection, segmentation, diagnosis, and analysis of digitalized images [1]. WSI indicates digital representation of an entire histopathologic glass slide at microscopic resolution [2]. Over the last two decades, WSI technology has evolved to encompass relatively high resolution, increased scanner capacity, faster scan speed, smaller image file sizes, and commercialization. The development of appropriate image management systems (IMS) and a seamless interface connection between existing hospital systems such as electronic medical records (EMR), picture archiving communication systems (PACS), and laboratory information systems (LIS) (also referred to as the pathol-Introduction to digital pathology and computer-aided pathology Digital pathology (DP) is no longer an unfamiliar term for pathologists, but it is still difficult for many pathologists to understand the engineering and mathematics concepts involved in DP. Computer-aided pathology (CAP) aids pathologists in diagnosis. However, some consider CAP a threat to the existence of pathologists and are skeptical of its clinical utility. Implementation of DP is very burdensome for pathologists because technical factors, impact on workflow, and information technology infrastructure must be considered. In this paper, various terms related to DP and computer-aided pathologic diagnosis are defined, current applications of DP are discussed, and various issues related to implementation of DP are outlined. The developmen...

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Section: Application Of Digital Pathologymentioning

confidence: 99%

Section: Application Of Digital Pathologymentioning

confidence: 99%

Section: Implementation Of Digital Pathology System For Clinical Diagmentioning

confidence: 99%

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Introduction to digital pathology and computer-aided pathology

Nam

Chong

Jung

et al. 2020

J Pathol Transl Med

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“…Static telecytology is the simplest modality and the earliest form of telecytology adopted for international use. The basic work flow is: (1) digital image capture, (2) digital storage, and (3) image forwarding.…”

Section: Ov Er V Ie W Of Te Le Cy Tolog Ymentioning

confidence: 99%

International telecytology: Current applications and future potential

Caron

Yan

et al. 2018

Diagnostic Cytopathology

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International telecytology can improve patient care by increasing access to regional and international expertise in cytopathology. The majority of international telecytology studies published to date have been based on static telepathology platforms. Overall concordance rates for these studies ranged from 71% to 93%. This is comparable to the concordance rates published for other studies comparing diagnoses made by digital still images to reference glass slides, which vary from 80% to 95%. Static telepathology systems are relatively cheap and easy to use, and have the potential to increase access to international experts in developing countries with limited resources. In contrast, resource-rich academic and private medical centers can use whole slide digital imaging (WSI) for telecytology consultation, though few studies have been published addressing this topic. International telepathology consultation services with digital whole slide image capabilities have been established at several academic medical centers including the University of Pittsburgh Medical Center (UPMC) and the University of California at Los Angeles (UCLA), through the UCLA Center for Telepathology and Digital Pathology. In a small series of 20 telecytology cases submitted to UCLA from 2014 to 2017 (10 gynecologic and 10 fine needle aspiration cases), a meaningful diagnosis was rendered for 100% of cases, with 100% concordance between the submitting institution, versus consultation diagnosis provided by UCLA. These limited results are promising, and in the future both WSI and static telecytology consultation may have a place serving clinical needs in different practice settings.

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“…The current interest in the use of WSI in primary diagnosis has impelled the report of guidelines proposing the basic needs (image quality, compression and file formats, for example) to implement this technology in order to help pathologists and IT personnel to make correct decisions when evaluating the increasing technological offer [9]. However, many of these recommendations are based on theoretical aspects, which should be tested before being introduced in real practice.…”

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confidence: 99%