International and collaborative strategies to enhance genetic health in purebred dogs

Hedhammar, Åke; Malm, S.; Bonnett, Brenda N.

doi:10.1016/j.tvjl.2011.06.018

Cited by 34 publications

(36 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Selective breeding in purebred animals has resulted in the loss of genetic diversity, accumulation of detrimental genes and exaggeration of anatomical features associated with physical health risks (41,43,44). Irresponsible breeding practices include the 'popular sire syndrome', i.e.…”

Section: Breedingmentioning

confidence: 99%

“…the overuse of individual breeding males leading to increased genetic homogeneity (4,45), and the intentional breeding of related animals by line breeding and inbreeding (4,44). The popular sire syndrome is likely to have been exacerbated by removal from the breeding population through castration (usually at the insistence of the breeder) of so-called 'pet quality' dogs who do not meet an exacting show standard but who are otherwise healthy and perfectly acceptable companion animals (43). Such practices result in, for example, Pekingese with longer noses and improved airflow not contributing to the breeding population and genetic variation.…”

Section: Breedingmentioning

confidence: 99%

“…Inbreeding increases frequencies of inherited disorders, especially in those breeds with small effective population sizes (1,42). Strong artificial selection for certain phenotypic traits may result in the selection of unintended traits because of the underlying genetic variance-co-variance matrices (43). For example, selection for the desired feature of curly tails in pugs is associated with an increased incidence of spina bifida (37), both of which are developmental anomalies.…”

Section: Breedingmentioning

confidence: 99%

“…Adequate data collection systems must record objective, valid information about individual animals, and these systems must be accessible and used (4,43,44). Good data on the mortality/morbidity of inherited conditions permit meaningful genetic evaluations.…”

Section: Breedingmentioning

confidence: 99%

See 3 more Smart Citations

Key determinants of dog and cat welfare: behaviour, breeding and household lifestyle

Sonntag¹,

Overall²

2014

Rev. Sci. Tech. OIE

View full text Add to dashboard Cite

SummaryThe changing role of companion animals, accompanied by changes in human lifestyle and demands, places them at risk of poor welfare. They are increasingly subjected to stressors that prevent the adequate expression of normal behaviour. Fear and anxiety often go unrecognised, leading to behavioural disorders that are accompanied by negative affective states and poor welfare. Irresponsible breeding practices result in increased incidences of inherited defects in pets, which adversely affect physical and mental aspects of welfare, either directly, through the anomaly itself, or indirectly, due to secondary effects. Increased urbanisation has resulted in smaller living spaces, higher population densities and longer working hours, all factors that affect the well-being of pets. A better understanding of animal behaviour by both pet owners and professionals, to more effectively meet the needs of dogs and cats and recognise their problems, should inform the formulation of objective welfare assessments to ensure a better quality of life for the animals. Responsible breeding practices that increase genetic diversity and select for traits that help dogs and cats fill their niche in a changing world should be based on evidence to minimise welfare risk.

show abstract

Section: Breedingmentioning

confidence: 99%

Section: Breedingmentioning

confidence: 99%

Section: Breedingmentioning

confidence: 99%

Section: Breedingmentioning

confidence: 99%

See 2 more Smart Citations

Key determinants of dog and cat welfare: behaviour, breeding and household lifestyle

Sonntag¹,

Overall²

2014

Rev. Sci. Tech. OIE

View full text Add to dashboard Cite

show abstract

“…Dog breeding is characterized by various breeding practices and regulations across countries (Hedhammar et al . ; Shariflou et al . ).…”

Section: Introductionmentioning

confidence: 99%

Merging pedigree databases to describe and compare mating practices and gene flow between pedigree dogs in France, Sweden and the UK

Wang

Leroy

Malm

et al. 2016

J Animal Breeding Genetics

View full text Add to dashboard Cite

Merging pedigree databases across countries may improve the ability of kennel organizations to monitor genetic variability and health-related issues of pedigree dogs. We used data provided by the Société Centrale Canine (France), Svenska Kennelklubben (Sweden) and the Kennel Club (UK) to study the feasibility of merging pedigree databases across countries and describe breeding practices and international gene flow within the following four breeds: Bullmastiff (BMA), English setter (ESE), Bernese mountain dog (BMD) and Labrador retriever (LBR). After merging the databases, genealogical parameters and founder contributions were calculated according to the birth period, breed and registration country of the dogs. Throughout the investigated period, mating between close relatives, measured as the proportion of inbred individuals (considering only two generations of pedigree), decreased or remained stable, with the exception of LBR in France. Gene flow between countries became more frequent, and the origins of populations within countries became more diverse over time. In conclusion, the potential to reduce inbreeding within purebred dog populations through exchanging breeding animals across countries was confirmed by an improved effective population size when merging populations from different countries.

show abstract

Empowering international canine inherited disorder management

Wilson

Wade

2011

Mamm Genome

View full text Add to dashboard Cite

The mapping of the canine genome and the study of canine breed genomic architecture has revolutionized the discovery of genetic tests for inherited disorders in dogs. As the genetics underlying complex disorders are revealed, canine breeders and their registering organisations will be required to understand genetics in a much more sophisticated way. To facilitate the management of genetic disorders in the era of new complex information, we consider how best to apply the results of new research and analytical techniques to benefit the wider canine breeding community with the aims of improving canine health and maintaining benevolent genetic diversity. If this is not done, there is a serious risk that expensive and valuable genetic research will remain unused or be misused to the detriment of breeds. In this review, we make a case for the formation of an international organisation that will exist as a central repository for breed-based genetic analysis and information sharing. This organisation ("Inter-Dog") could be modelled on a similar organisation that is monitoring genetic improvement of dairy cattle. The formation of such an organisation will require the collaboration of international kennel management organisations, researchers, and agencies offering genetic testing services.

show abstract

International and collaborative strategies to enhance genetic health in purebred dogs

Cited by 34 publications

References 38 publications

Key determinants of dog and cat welfare: behaviour, breeding and household lifestyle

Key determinants of dog and cat welfare: behaviour, breeding and household lifestyle

Merging pedigree databases to describe and compare mating practices and gene flow between pedigree dogs in France, Sweden and the UK

Empowering international canine inherited disorder management

Contact Info

Product

Resources

About