International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries

Bourgeois, Florence T.; Gutiérrez-Sacristán, Alba; Keller, Mark S; Liu, Molei; Hong, Chuan; Bonzel, Clara Lea; Tan, Byorn W.L.; Aronow, Bruce J.; Boeker, Martin; Booth, John; Rojo, Jaime Cruz; Devkota, Batsal; Barrio, Noelia García; Gehlenborg, Nils; Geva, Alon; Hanauer, David A.; Hutch, Meghan R.; Issitt, Richard; Klann, Jeffrey G.; Luo, Yuan; Mandl, Kenneth D.; Mao, Chengsheng; Moal, Bertrand; Moshal, Karyn; Murphy, Shawn N.; Neuraz, Antoine; Ngiam, Kee Yuan; Omenn, Gilbert S.; Patel, Lav P.; Pedrera-Jiménez, Miguel; Sebire, Neil J.; Balazote, Pablo Serrano; Serret-Larmande, Arnaud; South, Andrew M.; Spiridou, Anastasia; Taylor, Deanne; Tippmann, Patric; Visweswaran, Shyam; Weber, Griffin M; Kohane, Isaac S.; Cai, Tianxi; Avillach, Paul

doi:10.1001/jamanetworkopen.2021.12596

Cited by 33 publications

(32 citation statements)

References 40 publications

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“…Using the 4CE standard of common EHR data elements 28 – 31 , we collected demographics (age, gender, self-identified race/ethnicity) and the International Classification of Disease (ICD) codes (versions 9 or 10) pertaining to neurological conditions (Fig. 1 ) as well as COVID-19 severity, based on the internationally validated 4CE COVID-19 severity criteria 30 .…”

Section: Methodsmentioning

confidence: 99%

“…Electronic health records (EHRs) data can facilitate clinical discovery efforts. Our team created the International Consortium for Clinical Characterization of COVID-19 by EHR (4CE; http://www.covidclinical.net ) to standardize and aggregate multinational EHR data (from 34 healthcare systems and 338 affiliated hospitals across six countries at the time of data freeze for this study) to address critical clinical and epidemiological questions relevant to COVID-19 28 – 31 . Central to the 4CE effort is the ability of local clinician experts and data scientists at each contributing healthcare system to ensure the quality of common EHR data elements.…”

Section: Introductionmentioning

confidence: 99%

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Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

Gutiérrez-Sacristán

Son

et al. 2021

Sci Rep

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Neurological complications worsen outcomes in COVID-19. To define the prevalence of neurological conditions among hospitalized patients with a positive SARS-CoV-2 reverse transcription polymerase chain reaction test in geographically diverse multinational populations during early pandemic, we used electronic health records (EHR) from 338 participating hospitals across 6 countries and 3 continents (January–September 2020) for a cross-sectional analysis. We assessed the frequency of International Classification of Disease code of neurological conditions by countries, healthcare systems, time before and after admission for COVID-19 and COVID-19 severity. Among 35,177 hospitalized patients with SARS-CoV-2 infection, there was an increase in the proportion with disorders of consciousness (5.8%, 95% confidence interval [CI] 3.7–7.8%, pFDR < 0.001) and unspecified disorders of the brain (8.1%, 5.7–10.5%, pFDR < 0.001) when compared to the pre-admission proportion. During hospitalization, the relative risk of disorders of consciousness (22%, 19–25%), cerebrovascular diseases (24%, 13–35%), nontraumatic intracranial hemorrhage (34%, 20–50%), encephalitis and/or myelitis (37%, 17–60%) and myopathy (72%, 67–77%) were higher for patients with severe COVID-19 when compared to those who never experienced severe COVID-19. Leveraging a multinational network to capture standardized EHR data, we highlighted the increased prevalence of central and peripheral neurological phenotypes in patients hospitalized with COVID-19, particularly among those with severe disease.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

Gutiérrez-Sacristán

Son

et al. 2021

Sci Rep

Self Cite

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“…This increase in technology use is documented as the risk factor of developing psychological conditions [ 14 ]. In the summer of 2021 (June), different trends began to spread (loosening of restrictions, quota schedules, end of lockdown) all over the world united by two macro characteristics: the spread of the delta variant [ 15 ] and the younger age of coronavirus cases [ 16 ]. The analysis of the latter phenomenon is being studied by medicine since the causes of this further spread are multifactorial (less vaccinated age group, end of restrictions, etc.).…”

Section: Introductionmentioning

confidence: 99%

Psychological and Emotional Effects of Digital Technology on Children in COVID-19 Pandemic

Limone

Toto

2021

Brain Sciences

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COVID-19 has caused obstacles in continuing normal life almost everywhere in the world by causing the implementation of social distancing and eventually imposing the lockdown. This has become the reason for the increase in technology usage in daily life for professional work as well as for entertainment purposes. There has been an increased prevalence of technology usage in adolescents and children during lockdown leaving its impact on their lives either in a positive or negative aspect. The overall documented percentage increase of technology usage in children was about 15%, of which smartphone usage has 61.7% of prevalence. Disturbance in brain functioning is suggested to be originated by compromise of neuroplasticity of the nerves. The radiofrequency (RF) radiations emitting from the smartphone are of doubtful concern as a brain tumor risk factor in children. The increased usage can have effects on brain functioning that will compromise sleep and cognitive abilities and develop risk for certain mental illnesses including, but not limited to, depression, anxiety, Alzheimer’s disease, and attention-deficit/hyperactive disorder (ADHD). Despite being a threat for developing mental illness, video games are proven to reduce depression and anxiety, and increase creativity, skills, and cognition in children. The increased usage of technology can have a positive and negative impact on the mental development of adolescents and children depending on the trends in the usage. However, parents should be monitoring their children’s mental health and behavior in these difficult times of pandemic.

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“…Infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) has spread across the globe, causing almost 4 million deaths. Most reports relating to COVID-19 have focused primarily on adults, whereas several questions about children and adolescents infected by SARS-CoV-2 still remain unanswered [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

COVID 19 Vaccine for Adolescents. Concern about Myocarditis and Pericarditis

et al. 2021

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The alarming onset of some cases of myocarditis and pericarditis following the administration of Pfizer–BioNTech and Moderna COVID-19 mRNA-based vaccines in adolescent males has recently been highlighted. All occurred after the second dose of the vaccine. Fortunately, none of patients were critically ill and each was discharged home. Owing to the possible link between these cases and vaccine administration, the US and European health regulators decided to continue to investigate the potential causal relationship between COVID-19 mRNA vaccines and myocarditis. In any case, none of the patients fulfilled the criteria for multi-system inflammatory syndrome or Kawasaki-like disease and there was no evidence of acute SARS-CoV-2 infection.

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International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries

Abstract: This cohort study aims to describe international hospitalization trends and key epidemiological and clinical features of children and youth with COVID-19.

Cited by 33 publications

References 40 publications

Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19

Psychological and Emotional Effects of Digital Technology on Children in COVID-19 Pandemic

COVID 19 Vaccine for Adolescents. Concern about Myocarditis and Pericarditis

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