Internalizing and externalizing factors on the pathway from adverse experiences in childhood to non-medical prescription opioid use in adulthood

Quinn, Kimberly A.; Frueh, B. Christopher; Scheidell, Joy D.; Schatz, Daniel; Scanlon, Faith; Khan, Maria R.

doi:10.1016/j.drugalcdep.2018.12.029

Cited by 36 publications

(25 citation statements)

References 48 publications

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“…While the majority of these findings have not been specific to opioid use disorder (OUD), the number of studies targeting opioids has grown in recent years. Consistent with the relationships observed between ELS and other types of SUDS, the findings show that ELS is associated with increased risks for opioid use initiation, injection drug use, overdose, use disorder, and poor treatment outcome [ 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Nevertheless, empirical studies elucidating the neurobiological mechanisms linking ELS with vulnerability for OUD are lacking.…”

Section: Introductionsupporting

confidence: 76%

“…Similar findings were reported by Ghorbani et al [ 123 ], who showed that ELS was indirectly related to heroin craving via a limited ability to regulate emotions. Internalizing and externalizing symptoms have been shown to partially mediate the association between ELS and prescription opioid misuse [ 24 , 106 ]. These findings suggest that self-medication may play a role in generating and maintaining both recreational and prescription opioid misuse in ELS-exposed individuals [ 124 , 125 ].…”

Section: Evidence Of Els and Oud Associationsmentioning

confidence: 99%

“…Findings from several lines of research support speculations that ELS-related changes in circuits that underlie stress and emotion processing may represent an underlying opioid vulnerability pathway. For instance, impairments in AMG connectivity have been shown to mediate associations between ELS and internalizing symptoms in adolescents [ 155 ] while internalizing and externalizing symptoms partially mediate associations between ELS and opioid misuse [ 24 , 106 ]. These findings suggest that ELS may lead to changes in brain function that impair the ability to modulate emotions and to cope with stress, which may then lead to a range of maladaptive behaviors that can predispose to opioid misuse.…”

Section: Role Of Mesocorticolimbic Emotion Processing Circuits In Els and Oudmentioning

confidence: 99%

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Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Oswald

Dunn

Seminowicz

et al. 2021

JPM

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A robust body of research has shown that traumatic experiences occurring during critical developmental periods of childhood when neuronal plasticity is high increase risks for a spectrum of physical and mental health problems in adulthood, including substance use disorders. However, until recently, relatively few studies had specifically examined the relationships between early life stress (ELS) and opioid use disorder (OUD). Associations with opioid use initiation, injection drug use, overdose, and poor treatment outcome have now been demonstrated. In rodents, ELS has also been shown to increase the euphoric and decrease antinociceptive effects of opioids, but little is known about these processes in humans or about the neurobiological mechanisms that may underlie these relationships. This review aims to establish a theoretical model that highlights the mechanisms by which ELS may alter opioid sensitivity, thereby contributing to future risks for OUD. Alterations induced by ELS in mesocorticolimbic brain circuits, and endogenous opioid and dopamine neurotransmitter systems are described. The limited but provocative evidence linking these alterations with opioid sensitivity and risks for OUD is presented. Overall, the findings suggest that better understanding of these mechanisms holds promise for reducing vulnerability, improving prevention strategies, and prescribing guidelines for high-risk individuals.

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Section: Introductionsupporting

confidence: 76%

Section: Evidence Of Els and Oud Associationsmentioning

confidence: 99%

Section: Role Of Mesocorticolimbic Emotion Processing Circuits In Els and Oudmentioning

confidence: 99%

See 1 more Smart Citation

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Oswald

Dunn

Seminowicz

et al. 2021

JPM

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“…In previous research, authors have identified a number of shared risk factors for suicide-related behaviors and POM, such as previous exposure to adverse childhood experiences and underlying mental health conditions, such as depression and anxiety. [11][12][13][14] The co-occurrence of POM and suicide-related behaviors and experiences among high school students underscores the importance of comprehensive prevention approaches that address both challenges and their intersecting risks and protective factors. Communities can address the intersections of POM and youth suicide through upstream primary prevention approaches, such as preventing adverse childhood experiences (eg, child maltreatment or witnessing or experiencing violence), which have been linked to higher youth POM and suicide risk, 15,16 and by strengthening strategies that promote safe, stable, nurturing relationships and environments during childhood.…”

Section: Discussionmentioning

confidence: 99%

Current Prescription Opioid Misuse and Suicide Risk Behaviors Among High School Students

Wilkins

Clayton²,

Jones

et al. 2021

Pediatrics

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BACKGROUND AND OBJECTIVES: In previous studies, researchers have reported that youth with a lifetime history of prescription opioid misuse (POM) are at an increased risk for suicidal ideation, planning, and attempts. In this study, we investigate whether the association between youth POM and suicide outcomes differs by recency of POM (ie, none, past, or current misuse). METHODS: In this report, we use data from the 2019 Youth Risk Behavior Survey to examine associations between recency of POM (current POM, past POM, and no POM) and suicide risk behaviors among US high school students. RESULTS: After controlling for demographics, alcohol, and other drug use, both current POM and past POM were significantly associated with all suicide risk behaviors compared with no POM. Students who reported current POM had the highest adjusted prevalence ratios (aPRs) for suicidal ideation (aPR: 2.30; 95% confidence interval [CI] 1.97-2.69), planning (aPR: 2.33; 95% CI 1.99-2.79), attempts (aPR: 3.21; 95% CI 2.56-4.02), and feeling sad or hopeless (aPR: 1.59; 95% CI 1.37-1.84). Students who reported current POM also were significantly more likely than youth who reported past POM to report that they had seriously considered attempting suicide, made a suicide plan, and attempted suicide. CONCLUSIONS: Although POM, particularly current POM, is associated with increases in the risk for suicide-related behaviors and experiences of youth, comprehensive prevention approaches that address the intersections between suicide and POM provide a promising path forward for addressing these public health challenges among youth.

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“…Limited research has assessed the relationship between school experiences and pain reliever misuse among high school students nationwide. Much of the literature has focused on other potential risk factors such as peer norms, childhood trauma, and socioeconomic influences on pain reliever misuse (Ford, Sacra, & Yohros, 2017;Oluwoye, Merianos, & Nabors, 2017;Quinn et al, 2016;Quinn et al, 2019). Thus, assessing school-related risk factors may be beneficial for guiding future improvements in school-based substance use programs.…”

Section: Introductionmentioning

confidence: 99%

Negative School Experiences and Pain Reliever Misuse among a National Adolescent Sample

Wood¹,

King²,

Vidourek³

et al. 2019

Health Behavior Research

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A recent public health concern is the nonmedical use of prescription drugs among U.S. adolescents. The purpose of this study was to determine the relationship between negative school experiences and lifetime and past year pain reliever misuse among adolescents enrolled in high school nationwide. A secondary analysis was performed using the National Survey on Drug Use and Health 2017 data. Participants included 8,337 adolescents enrolled in 9 th-12 th grades. A total of 6.0% of high school students reported they had misused pain relievers in their lifetime, and 3.9% reported they had misused pain relievers during the past year. High school students who reported the following negative school experiences were at increased odds of reporting lifetime pain reliever misuse: liked/hated going to school (adjusted OR [aOR] = 2.04, 95% confidence interval [CI] = 1.66-2.50); felt their coursework was somewhat/very boring (aOR = 1.81, 95%CI = 1.48-2.22), seldom/never meaningful (aOR = 2.01, 95%CI = 1.64-2.45), and/or would be somewhat/very unimportant to them later in life (aOR = 1.64, 95%CI = 1.33-2.01); and had teachers who seldom/never let them know they were doing a good job (aOR = 1.71, 95%CI = 1.40-2.09). High school students who had a "D" grade average or lower (aOR = 2.69, 95%CI = 1.89-3.82) and skipped school on at least one day (aOR = 2.18, 95%CI = 1.76-2.70) were more likely to report lifetime use. Similar significant findings were reported between negative school experiences and past year pain reliever misuse. Negative school experiences are risk factors for lifetime and past year pain reliever misuse among U.S. adolescents. Programming that reduces students' negative school experiences may create a positive environment, and in turn, reduce misuse.

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Internalizing and externalizing factors on the pathway from adverse experiences in childhood to non-medical prescription opioid use in adulthood

Cited by 36 publications

References 48 publications

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Current Prescription Opioid Misuse and Suicide Risk Behaviors Among High School Students

Negative School Experiences and Pain Reliever Misuse among a National Adolescent Sample

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