Internalization of the Aspergillus nidulans AstA Transporter into Mitochondria Depends on Growth Conditions, and Affects ATP Levels and Sulfite Oxidase Activity

Piłsyk, Sebastian; Mieczkowski, Adam; Golan, Maciej P.; Wawrzyniak, Agata; Kruszewska, Joanna S.

doi:10.3390/ijms21207727

Cited by 7 publications

(5 citation statements)

References 44 publications

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“…Studies in A. nidulans have demonstrated that the sB gene is located on chromosome VI, whose transcriptional regulation relies on sulfur sources. 90 , 91 Defective sB gene strains did not grow on sulfate as the sole sulfur source. However, they grew well on choline sulfate, which is taken up by a different permease.…”

Section: Sulfate Permeases In Fungimentioning

confidence: 99%

“…However, experiments on mutants compromised with methionine to cysteine conversion indicated that the mutants are regulatory effectors. 90 , 94 This transcriptional regulation is dependent on the sulfur metabolite repression (SMR) system. 93–95 96 97 Recently, it has been observed that high-affinity sulfate transporter of S. indica (SiSulT) uptake sulfate from media and transfer to the host plant.…”

Section: Sulfate Permeases In Fungimentioning

confidence: 99%

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Sulfur nutrition and its role in plant growth and development

Narayan

Kumar

Yadav

et al. 2022

Plant Signaling & Behavior

111

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Sulfur is one of the essential nutrients that is required for the adequate growth and development of plants. Sulfur is a structural component of protein disulfide bonds, amino acids, vitamins, and cofactors. Most of the sulfur in soil is present in organic matter and hence not accessible to the plants. Anionic form of sulfur (SO 4 2− ) is the primary source of sulfur for plants that are generally present in minimal amounts in the soil. It is water-soluble, so readily leaches out of the soil. Sulfur and sulfur-containing compounds act as signaling molecules in stress management as well as normal metabolic processes. They also take part in crosstalk of complex signaling network as a mediator molecule. Plants uptake sulfate directly from the soil by using their dedicated sulfate transporters. In addition, plants also use the sulfur transporter of a symbiotically associated organism like bacteria and fungi to uptake sulfur from the soil especially under sulfur depleted conditions. So, sulfur is a very important component of plant metabolism and its analysis with different dimensions is highly required to improve the overall well-being of plants, and dependent animals as well as human beings. The deficiency of sulfur leads to stunted growth of plants and ultimately loss of yield. In this review, we have focused on sulfur nutrition, uptake, transport, and inter-organismic transfer to host plants. Given the strong potential for agricultural use of sulfur sources and their applications, we cover what is known about sulfur impact on the plant health. We identify opportunities to expand our understanding of how the application of soil microbes like AMF or other root endophytic fungi affects plant sulfur uptake and in turn plant growth and development.

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Section: Sulfate Permeases In Fungimentioning

confidence: 99%

Section: Sulfate Permeases In Fungimentioning

confidence: 99%

Sulfur nutrition and its role in plant growth and development

Narayan

Kumar

Yadav

et al. 2022

Plant Signaling & Behavior

111

View full text Add to dashboard Cite

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“…In addition, sulphate transporter family-domaincontaining protein (B50aA3880) was supposed to be characterised as one of the MFS transporters and required for efficient sulphate uptake. 27 Besides, vacuolar amino acid transporter (AVT, B50aA7737)…”

Section: Influx-efflux Pumps Consist Of Transmembrane Proteinsmentioning

confidence: 99%

A thermal adaptation landscape related to virulence in Mucor irregularis transcriptional profiles

Zhang

Liang

Dong

et al. 2021

Mycoses

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The incidence rate of mucormycosis, one deep fungal disease caused by Mucorales, has rapidly increased over recent years. A multi-centre retrospective observational study on adult non-Aspergillus infections from 2004 to 2012 had reported that Mucorales has become the second most common mould pathogens after Aspergillus. 1 One recent statistical analysis of 851 mucormycosis cases from 2000 to 2017 exhibited that Mucorales spp. accounted for 14% (63/447) of the causative pathogens, in which about 8% (5/63) were Mucor irregularis (M. irregularis). 2 M. irregularis, formerly known as Rhizomucor variabilis, was firstly isolated from a Chinese patient with cutaneous mucormycosis in

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“…The MFS transporters are one of the largest superfamilies of membrane transporters [ 14 , 15 , 16 ]. They have a broad spectrum of substrates, including sugars, polyols, metabolites and even inorganic tetraoxyanions [ 14 , 15 , 17 ]. Most MFS transporters harbor either 12 or 14 putative transmembrane domains (TM) [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Major Facilitator Superfamily Transporter Gene Aokap4 near the Kojic Acid Gene Cluster Is Involved in Growth and Kojic Acid Production in Aspergillus oryzae

Chen

et al. 2022

JoF

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Kojic acid is an important secondary metabolite of industrial importance produced by Aspergillus oryzae. The kojic acid gene cluster plays an essential role in kojic acid production, and harbors kojA, kojR and kojT. The deletion of kojT, encoding a major facilitator superfamily (MFS) transporter, did not completely abolish kojic acid production, implying that other transporters are required for the transport of kojic acid. The aim of this study is to look for the transporters involved in kojic acid production. Here, Aokap4 encoding a novel MFS transporter was identified, which was adjacent to kojT in the kojic acid gene cluster. The deletion of Aokap4 contributed to the hyphal growth, conidial production and biomass of A. oryzae. Moreover, Aokap4 is required for heat- and cell-wall-stress tolerance but not oxidative and osmotic stress. The disruption of Aokap4 impaired kojic acid production with the reduced expression of kojA, kojR and kojT. Furthermore, when kojT was deleted in the Aokap4-disrupted strain, the yield of kojic acid declined to the same level as that of the kojT-deletion mutant, whereas the production of kojic acid was recovered when kojT was overexpressed in the Aokap4 knockout strain, suggesting that kojT acts downstream of Aokap4. AoKap4 was the second identified MSF transporter involved in kojic acid production after kojT was found a decade ago. This study contributes to a better understanding of the biological roles of the MFS transporter and lays a foundation for future studies on kojic acid synthesis in A. oryzae.

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Internalization of the Aspergillus nidulans AstA Transporter into Mitochondria Depends on Growth Conditions, and Affects ATP Levels and Sulfite Oxidase Activity

Cited by 7 publications

References 44 publications

Sulfur nutrition and its role in plant growth and development

Sulfur nutrition and its role in plant growth and development

A thermal adaptation landscape related to virulence in Mucor irregularis transcriptional profiles

A Novel Major Facilitator Superfamily Transporter Gene Aokap4 near the Kojic Acid Gene Cluster Is Involved in Growth and Kojic Acid Production in Aspergillus oryzae

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