Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell

Xu, Mingkai; Halimu, Gulinare; Zhang, Qianru; Song, Yiling; Fu, Xuanhe; Li, Yongqiang; Li, Yansheng; Zhang, Huiwen

doi:10.1016/j.scitotenv.2019.133794

Cited by 340 publications

(182 citation statements)

References 32 publications

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“…In this connection, Dong and colleagues found that PS MPs produced some cytotoxic effects, oxidative stress, and inflammatory responses in human lung epithelial cells, and are disruptive of the epithelial cell layer, at least in vitro [120]. Two other groups have recently checked the toxicity of NPs in lung [121] and bronchial [122] cells. Xu and colleagues found that PS NPs (25 and 70 nm) impaired viability, induced cell cycle arrest, and upregulated nuclear factor (NF)-κB as well as some pro-inflammatory cytokines in the human alveolar epithelial line A549 [121].…”

Section: Toxicity Of Mps/nps In Human Cellsmentioning

confidence: 99%

“…Two other groups have recently checked the toxicity of NPs in lung [121] and bronchial [122] cells. Xu and colleagues found that PS NPs (25 and 70 nm) impaired viability, induced cell cycle arrest, and upregulated nuclear factor (NF)-κB as well as some pro-inflammatory cytokines in the human alveolar epithelial line A549 [121]. On the other hand, Lim and colleagues noted that PS NPs are only cytotoxic at high concentrations but induced metabolic changes and endoplasmic reticulum (ER) stress in a human bronchial epithelial cell line [122].…”

Section: Toxicity Of Mps/nps In Human Cellsmentioning

confidence: 99%

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Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

460

243

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Fragmented or otherwise miniaturized plastic materials in the form of micro- or nanoplastics have been of nagging environmental concern. Perturbation of organismal physiology and behavior by micro- and nanoplastics have been widely documented for marine invertebrates. Some of these effects are also manifested by larger marine vertebrates such as fishes. More recently, possible effects of micro- and nanoplastics on mammalian gut microbiota as well as host cellular and metabolic toxicity have been reported in mouse models. Human exposure to micro- and nanoplastics occurs largely through ingestion, as these are found in food or derived from food packaging, but also in a less well-defined manner though inhalation. The pathophysiological consequences of acute and chronic micro- and nanoplastics exposure in the mammalian system, particularly humans, are yet unclear. In this review, we focus on the recent findings related to the potential toxicity and detrimental effects of micro- and nanoplastics as demonstrated in mouse models as well as human cell lines. The prevailing data suggest that micro- and nanoplastics accumulation in mammalian and human tissues would likely have negative, yet unclear long-term consequences. There is a need for cellular and systemic toxicity due to micro- and nanoplastics to be better illuminated, and the underlying mechanisms defined by further work.

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Section: Toxicity Of Mps/nps In Human Cellsmentioning

confidence: 99%

Section: Toxicity Of Mps/nps In Human Cellsmentioning

confidence: 99%

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Yong

Valiyaveettil

Tang

2020

IJERPH

460

243

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“…Nanoplastic exposure reduced cell viability, induced cell cycle S phase arrest, and up-regulation of pro-in ammatory cytokines and pro-apoptotic proteins. Importantly, exposure duration, particle diameter, and concentration were key determinants of the toxicological effects of polystyrene nanoparticle exposure on alveolar epithelial cells [17].…”

mentioning

confidence: 99%

Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy

Fournier

D’Errico

Adler

et al. 2020

Preprint

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Abstract Background: Plastic is everywhere. It is used in food packaging, storage containers, electronics, furniture, clothing, and common single-use disposable items. Microplastic and nanoplastic particulates are formed from bulk fragmentation and disintegration of plastic pollution. Plastic particulates have recently been detected in indoor air and remote atmospheric fallout. Due to their small size, microplastic and nanoplastic particulate in the atmosphere can be inhaled and may pose a risk for human health, specifically in susceptible populations. When inhaled, nanosized particles have been shown to translocate across pulmonary cell barriers to secondary organs, including the placenta. However, the potential for maternal-to-fetal translocation of nanosized-plastic particles and the impact of nanoplastic deposition and accumulation on fetal health remain unknown. In this study we investigated whether nanopolystyrene particles can cross the placental barrier and deposit in fetal tissues after maternal pulmonary exposure.Results: Pregnant Sprague Dawley rats were exposed to 20 nm rhodamine-labeled nanopolystyrene beads (2.64 x 1014 particles) via intratracheal instillation on gestational day (GD) 19. Twenty-four hours later on GD 20, maternal and fetal tissues were evaluated using fluorescent optical imaging. Fetal tissues were fixed for particle visualization with hyperspectral microscopy. Using isolated placental perfusion, a known concentration of nanopolystyrene was injected into the uterine artery. Maternal and fetal effluents were collected for 180 minutes and assessed for polystyrene particle concentration. Twenty-four hours after maternal exposure, fetal and placental weights were significantly lower (7% and 8%, respectively) compared with controls. Nanopolystyrene particles were detected in the maternal lung, heart, and spleen. Polystyrene nanoparticles were also observed in the placenta, fetal liver, lungs, heart, kidney, and brain suggesting maternal lung-to-fetal tissue nanoparticle translocation in late stage pregnancy.Conclusion: These studies confirm that maternal pulmonary exposure to nanopolystyrene results in the translocation of plastic particles to placental and fetal tissues and renders the fetoplacental unit vulnerable to adverse effects. These data are vital to the understanding of plastic particulate toxicology and the developmental origins of health and disease.

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“…In addition to bio-persistence, fiber size has an impact in their toxicity [151]; for example, fibers of 15-20 µm cannot be successfully removed from macrophages to the lungs. Additionally, in [167], the toxicity of smaller-sized polystyrene nanoparticles (25 nm in diameter), which induced lower cell viability, cell cycle arrest in the S phase, the transcription of the activated inflammatory gene, and changed protein expression that was associated with the cell cycle and pro-apoptosis, was demonstrated. Not to be overlooked is the potential transmission of microorganisms through the microplastics that are present in the air.…”

Section: Effects Of Micro and Nanoplastics On Human Healthmentioning

confidence: 99%

A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health

Campanale

Massarelli

Savino

et al. 2020

IJERPH

909

378

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The distribution and abundance of microplastics into the world are so extensive that many scientists use them as key indicators of the recent and contemporary period defining a new historical epoch: The Plasticene. However, the implications of microplastics are not yet thoroughly understood. There is considerable complexity involved to understand their impact due to different physical–chemical properties that make microplastics multifaceted stressors. If, on the one hand, microplastics carry toxic chemicals in the ecosystems, thus serving as vectors of transport, they are themselves, on the other hand, a cocktail of hazardous chemicals that are added voluntarily during their production as additives to increase polymer properties and prolong their life. To date, there is a considerable lack of knowledge on the major additives of concern that are used in the plastic industry, on their fate once microplastics dispose into the environment, and on their consequent effects on human health when associated with micro and nanoplastics. The present study emphasizes the most toxic and dangerous chemical substances that are contained in all plastic products to describe the effects and implications of these hazardous chemicals on human health, providing a detailed overview of studies that have investigated their abundance on microplastics. In the present work, we conducted a capillary review of the literature on micro and nanoplastic exposure pathways and their potential risk to human health to summarize current knowledge with the intention of better focus future research in this area and fill knowledge gaps.

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Internalization and toxicity: A preliminary study of effects of nanoplastic particles on human lung epithelial cell

Cited by 340 publications

References 32 publications

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Toxicity of Microplastics and Nanoplastics in Mammalian Systems

Nanopolystyrene Translocation and Fetal Deposition After Acute Lung Exposure During Late-Stage Pregnancy

A Detailed Review Study on Potential Effects of Microplastics and Additives of Concern on Human Health

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