1993
DOI: 10.1016/0014-5793(93)80212-d
|View full text |Cite
|
Sign up to set email alerts
|

Internalization and degradation of hepatocyte growth factor in hepatocytes with down‐regulation of the receptor/c‐Met

Abstract: Hepatocyte growth factor (HGF) promotes proliferation of cultured hepatocytes by its interaction with cell surface receptors. In this paper, we examined the metabolic fate of HGF using hepatocytes. Kinetic analysis using ["'I]HGF showed that 40% of surface-bound HGF was rapidly internalized in hepatocytes within 30 min at 37°C. Under these conditions, the amount of HGF-bound c-Met, the high-affinity receptor, decreased from the cell surface. Furthermore, the internalized HGF was degraded and released from the … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
18
1

Year Published

1997
1997
2007
2007

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 36 publications
(22 citation statements)
references
References 28 publications
3
18
1
Order By: Relevance
“…Consistent with others' results [33][34][35], in HBEpCs HGF (25 ng/ml) treatment for 30 min induced c-Met internalization from plasma membrane to cytoplasm and perinuclear compartment in a dose-dependent fashion (Fig. 7A).…”
Section: The Effect Of Lpa On Hgf / C-met-mediated C-met Internalizatsupporting
confidence: 92%
See 3 more Smart Citations
“…Consistent with others' results [33][34][35], in HBEpCs HGF (25 ng/ml) treatment for 30 min induced c-Met internalization from plasma membrane to cytoplasm and perinuclear compartment in a dose-dependent fashion (Fig. 7A).…”
Section: The Effect Of Lpa On Hgf / C-met-mediated C-met Internalizatsupporting
confidence: 92%
“…Ligand-dependent endocytosis of RTKs was the common mechanism of receptor inactivation and recycling [30][31][32][33][34][35]44,45]. Consistent to the study in HeLa cells [35], the binding of HGF to c-Met triggers internalization and redistribution of c-Met to the perinulear compartment in HBEpCs.…”
Section: Discussionmentioning
confidence: 63%
See 2 more Smart Citations
“…tcHGF/SF is rapidly internalized and degraded. 41 The second phase is the productive phase (3 to 72 hours). It is characterized by an increase in the levels of scHGF/SF and active tcHGF/SF.…”
Section: Discussionmentioning
confidence: 99%