Internalization and Coreceptor Expression Are Critical for TLR2-Mediated Recognition of Lipoteichoic Acid in Human Peripheral Blood

Bunk, Sebastian; Sigel, Stefanie; Metzdorf, Daniela; Sharif, Omar; Triantafilou, Kathy; Triantafilou, Martha; Hartung, Thomas; Knapp, Sylvia; Aulock, Sonja von

doi:10.4049/jimmunol.0901660

Cited by 54 publications

(41 citation statements)

References 52 publications

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“…Assessments of receptor function were conducted using blocking antibodies: mouse anti-human FcγRI (Biolegend); mouse anti-human FcγRII (Abcam); and mouse anti-human FcγRIII (Abcam), which have been previously described to block the antibody Fc-mediated functions of different FcγR family members (73)(74)(75). Blocking experiments with specific or nonspecific IgG4 antibodies were conducted using a 3:1 (IgG4/IgG1) ratio.…”

Section: Methodsmentioning

confidence: 99%

IgG4 subclass antibodies impair antitumor immunity in melanoma

Karagiannis

Gilbert²,

Josephs³

et al. 2013

J. Clin. Invest.

174

205

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Section: Methodsmentioning

confidence: 99%

IgG4 subclass antibodies impair antitumor immunity in melanoma

Karagiannis

Gilbert²,

Josephs³

et al. 2013

J. Clin. Invest.

174

205

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“…Such immune modulation is well described for FcγR triggering by immune complexes, which results in the generation, secretion, or repression of various pro-or anti-inflammatory substances (247, 248,249,250,251,252,253,254,255,256). In addition to modulation of cytokines by FcRs themselves, internalization of immune complexes via FcRs can result in the engagement of toll-like receptors, adding a further layer of complexity and control over inflammation (255,257,258,259,260).…”

Section: Other Antibody Functionsmentioning

confidence: 99%

Functions of Antibodies

Forthal

2014

Microbiol Spectr

152

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Antibodies can impact pathogens in the presence or in the absence of effector cells or effector molecules such as complement, and experiments can often sort out with precision the mechanisms by which an antibody inhibits a pathogen in vitro. In addition, in vivo models, particularly those engineered to knock in or knock out effector cells or effector molecules, are excellent tools for understanding antibody functions. However, it is highly likely that multiple antibody functions occur simultaneously or sequentially in the presence of an infecting organism in vivo. The most critical incentive for measuring antibody functions is to provide a basis for vaccine development and for the development of therapeutic antibodies. In this respect, some functions, such as virus neutralization, serve to inhibit the acquisition of a pathogen or limit its pathogenesis. However, antibodies can also enhance replication or contribute to pathogenesis. This review emphasizes those antibody functions that are potentially beneficial to the host. In addition, this review will focus on the effects of antibodies on organisms themselves, rather than on the toxins the organisms may produce.

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“…The authors analyzed the fulfillment of the Koch/Dale criteria (Dale, 1929) for the three membrane components lipoteichoic acid, peptidoglycan, and bacterial lipoproteins. they found enough evidence to conclude that ltA, PGN, mechanisms emerge, where receptor complexes form dynamically in contact with pyrogens (Pfeiffer et al, 2001;Triantafilou et al, 2004aTriantafilou et al, ,b, 2006 and internalization plays an additional role (Bunk et al, 2010;Nilsen et al, 2008).…”

Section: Gram-positive Bacteriamentioning

confidence: 99%