Internal State-Dependent Conditioned Stimulus Delivery Using Cardiovascular Telemetry in Mice
Abstract:To further understand mechanisms of neuropsychiatric disease(s) and their impact on physiological systems, improved pre-clinical models and innovative methodology are needed to assess the internal physiological state of the animal in real-time. To address this challenge we developed a customizable software-based program for Ponemah™ that takes into account the animal's diurnal and resting cardiovascular state in a home-cage environment. Using an integrated Pavlovian fear conditioning and cardiovascular telemet… Show more
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