Internal redistribution of tissue protein synthesis in uremia

Shear, Leroy

doi:10.1172/jci106090

Cited by 43 publications

(15 citation statements)

References 13 publications

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“…Uremia may also be accompanied by a catabolic state characterized by muscle wasting (7,8), decreased production of albumin (9,10), and abnormalities in plasma amino acids, primarily determined by the dietary protein intake (7,11). Wang et al (7) have demonstrated that uremic rats use protein less efficiently and have impaired growth despite adequate protein and caloric intake.…”

Section: Introductionmentioning

confidence: 99%

“…Wang et al (7) have demonstrated that uremic rats use protein less efficiently and have impaired growth despite adequate protein and caloric intake. The incorporation of L-[4C]leucine into muscle protein was shown to be reduced in uremia, whereas L-['4C]leucine incorporation in liver was increased (11). Furthermore, the conversion of phenylalanine to tyrosine may be impaired, possibly because ofthe inhibition ofthe enzyme phenylalanine hydroxy-lase by the uremic state (12).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Reduced Renal Mass and Dietary Protein Intake on Amino Acid Release and Glucose Uptake by Rat Muscle In Vitro

Harter¹,

Karl²,

Klahr³

et al. 1979

J. Clin. Invest.

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A B S T R A C T Epitrochlearis musclesTyrosine (TYR) and phenylalanine (PHE) release rates also were increased in muscles from Nx rats compared with C after 1 h of incubation. Release rates were highest in the Nx group fed 10% casein and decreased with increasing protein intake. Addition of insulin decreased the release rates of Nx rats to C values in each group. After 3 h of incubation, release rates of TYR and PHE in muscles from Nx rats remained significantly above C values for all groups, but responded to the addition of insulin with a decrease to C values. Glutamine and glutamate release were not significantly affected by reduction in renal mass.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Reduced Renal Mass and Dietary Protein Intake on Amino Acid Release and Glucose Uptake by Rat Muscle In Vitro

Harter¹,

Karl²,

Klahr³

et al. 1979

J. Clin. Invest.

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“…48 h after bilateral nephrectomy, Shear (37) injected ['4Cjleucine into rats and found that incorporation of the label into muscle protein was reduced; rates of muscle protein catabolism and net protein turnover were not reported. Differences in the rates of uptake and of metabolism of leucine also were not reported.…”

Section: Resultsmentioning

confidence: 99%

Muscle protein turnover and glucose uptake in acutely uremic rats. Effects of insulin and the duration of renal insufficiency.

Clark¹

1983

J. Clin. Invest.

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A B S T R A C T Acute renal failure (ARF) in rats is associated with increased amino acid release from peripheral tissues and insulin resistance. To study whether abnormal protein and carbohydrate metabolism are linked in ARF, the effects of insulin on net muscle protein degradation (T) and on glucose uptake were measured in the perfused hindquarters of paired ARF and sham-operated (SO) rats. The basal rate of T increased 40% after 24 and 98% after 48 h of ARF. Insulin was less effective in decreasing T in ARF (-79% SO vs. -22% ARF 24 h and -64% SO vs. -23% ARF 48 h; P < 0.01). Protein synthesis (PS) and protein degradation (PD) were measured independently in incubated epitrochlearis muscles; the increase in T after 24 h of ARF was due specifically to increased PD, while PS was unchanged. At this stage, insulin was less effective in decreasing PD in ARF (-10% ARF vs. -23% SO; P < 0.02), although PS responded normally. After 48 h of ARF, the further increment in T was caused by the additional appearance of depressed basal and insulin-stimulated PS. This was confirmed in the perfused hindquarter (26±3 ARF vs. 38±3 SO, basal; 54±5 ARF vs. 73±7 SO, insulin-stimulated, nmol phenylalanine/g per h; P < 0.05).Although basal glucose uptake by hindquarters of ARF and SO rats was comparable, insulin-stimulated glucose uptake was 33% less at 24 and 44% less after 48 h of ARF. After 48 h of ARF, lactate and alanine release were increased and net glycogen synthesis in muscle was depressed. These abnormalities were even more apparent in the presence of insulin. Inefficient glucose utilization, estimated as the ratio of lactate Address reprint requests to Dr. Mitch.

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“…It should be mentioned that the findings of decreased protein synthesis in skeletal muscle do not necessarily reflect similar events in other tissues. Shear [27] found that in rats with ARF the liver and cardiac muscle had increased rates of protein synthe sis, while that in skeletal muscle was reduced. Further.…”

Section: Catabolism In Arfmentioning

confidence: 99%

Parenteral Nutrition in Acute Renal Failure

Feinstein¹

1985

Am J Nephrol

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Internal redistribution of tissue protein synthesis in uremia

Cited by 43 publications

References 13 publications

Effects of Reduced Renal Mass and Dietary Protein Intake on Amino Acid Release and Glucose Uptake by Rat Muscle In Vitro

Effects of Reduced Renal Mass and Dietary Protein Intake on Amino Acid Release and Glucose Uptake by Rat Muscle In Vitro

Muscle protein turnover and glucose uptake in acutely uremic rats. Effects of insulin and the duration of renal insufficiency.

Parenteral Nutrition in Acute Renal Failure

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