Abstract:We investigated the capability of internal normal modes
to reproduce
RNA flexibility and predict observed RNA conformational changes and,
notably, those induced by the formation of RNA-protein and RNA-ligand
complexes. Here, we extended our iNMA approach developed for proteins
to study RNA molecules using a simplified representation of the RNA
structure and its potential energy. Three data sets were also created
to investigate different aspects. Despite all the approximations,
our study shows that iNMA is a su… Show more
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