Internal limiting membrane transplantation for unclosed and large macular holes

Dai, Yining; Fang, Dong; Zhang, Xiao; Yang, Zhikun

doi:10.1007/s00417-016-3461-4

Cited by 67 publications

(40 citation statements)

References 14 publications

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“…Many techniques have been proposed to increase closure rate in recurrent HMMH with RD, such as autologous blood (Lai et al 2015), ILM free patch (Morizane et al 2014;Dai et al 2016;Chen et al 2018) and retinal autograft (Grewal & Mahmoud 2016;Wu et al 2018). The purpose behind these techniques was to find a substrate to seal the MH in order to prevent fluid passing through the MH to the subretinal space, and to allow tissue proliferation in order to obtain retinal restoration and VA recovery.…”

Section: Discussionmentioning

confidence: 99%

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Caporossi

Angelis

Pacini

et al. 2019

Acta Ophthalmologica

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Objective To assess the efficacy of the human amniotic membrane (hAM) to treat (HMMH) associated with retinal detachment (RD). Material and Methods Ten eyes of 10 patients with recurrent HMMH and RD, who had already undergone one or more pars plana vitrectomy (PPV), underwent a PPV with an hAM plug implanted in the macular hole. The initial five patients enrolled were tamponaded with (SO) while the subsequent five patients with 10% octafluoropropane (C3F8). Silicon oil was removed in all five patients 2 months later. No statistical differences were reported between the two groups. Results Final retinal reattachment was achieved in all the patients. BCVA improved from 1.73 logMAR to 0.94 logMAR after 6 months. No adverse events were registered during follow‐up. Conclusion An hAM plug is an efficient substrate to manage HMMH associated with RD resulting in encouraging visual acuity recovery.

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Section: Discussionmentioning

confidence: 99%

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Caporossi

Angelis

Pacini

et al. 2019

Acta Ophthalmologica

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“…In 2010, Michalewska et al [12] reported an inverted ILM flap technique that improved both the functional and anatomical results for large MHs. In 2016, Dai et al [13] reported a free-flap transplantation of an autologous ILM for large MHs. However, these techniques cannot be applied when the ILM has already been removed in a previous surgery.…”

Section: Introductionmentioning

confidence: 99%

Autologous Neurosensory Retinal Transplantation for Unclosed and Large Macular Holes

Ding

Zeng

2018

Ophthalmic Res

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Purpose: The aim of this study was to demonstrate the surgical technique and clinical outcome of autologous neurosensory retinal patch transplantation for recurrent large macular hole (MH)-induced retinal detachment after failed surgery with internal limiting membrane (ILM) removal or transplantation. Methods: We reviewed 5 patients with recurrent MH-induced retinal detachment after failed surgeries with ILM removal or transplantation who underwent vitrectomy combined with autologous neurosensory retinal patch transplantations and were followed up over 6 months. In the autologous neurosensory retinal patch transplantation procedure, a small piece of neurosensory retina was removed and transplanted inside the MH. The anatomic outcomes of MH-induced retinal detachment were evaluated by fundus examinations and optical coherence tomography. The preoperative and postoperative best-corrected visual acuities (BCVAs) were compared and the MH closure rates were measured as the main outcomes. Results: A total of 5 patients (3 men and 2 women; average age 35.4 ± 18.72 years) were included in our study. Complete MH sealing was achieved in 5 eyes after autologous neurosensory retinal patch transplantations, and no complications were observed. The mean BCVA was 2.38 ± 0.57 (range 1.6–3) before surgery, and 1.46 ± 0.51 (range 1–2) at 6 postoperative months. There was a significant difference in BCVA before versus after the surgery (p < 0.05, paired t test). Conclusions: Autologous neurosensory retinal patch transplantation is an effective addition to the surgical options for large MH-induced retinal detachment after failed surgery with ILM removal or transplantation.

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“…This fluid, combined with the movement of the globe, could produce turbulence, which may dislocate the ILM flap from the MH after surgery. Thus, retinal glue such as OVD to stabilize the ILM flap has been used to resolve the problem [5,7,11,12]. However, OVD application onto MH or ILM is challenging in a fluid-filled eye.…”

Section: Discussionmentioning

confidence: 99%

Sub-perfluoro-n-octane injection of ocular viscoelastic device assisted inverted internal limiting membrane flap for macular hole retinal detachment surgery: a novel technique

Lai

Chou

et al. 2020

BMC Ophthalmol

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Background: To evaluate the feasibility of a surgical technique using a sub-perfluoro-n-octane (PFO) injection of ocular viscoelastic device (OVD) to stabilize inverted internal limiting membrane (ILM) flap for the treatment of macular hole retinal detachment (MHRD). Methods: This study was a retrospective, consecutive, interventional case series. Patients who underwent MHRD surgery with sub-PFO injection of OVD to stabilize inverted ILM flap onto the macular hole (MH) were reviewed. The color fundus and optical coherence tomography (OCT) images were collected and evaluated. The bestcorrected visual acuity (BCVA) before and after surgery were compared as the functional outcome. Results: The study included 8 eyes of 8 consecutive patients (mean age: 61.8 ± 7.1 years; mean follow-up period: 9.0 ± 2.5 months). All eyes (100%) achieved successful MH closure; 7 eyes (87.5%) demonstrated complete retinal reattachment, and 1 eye (12.5%) had minimal residual subretinal fluid parafoveally. Of the 8 patients, 7 patients (87.5%) had achieved improvement in BCVA after the primary surgery, whereas 1 eye remained stable. The average BCVA before and after the surgery at the last visit improved from 20/843 (1.63 ± 0.48 logMAR) to 20/200 (1.00 ± 0.39 logMAR) (P = 0.016). Anatomically, near-normal foveal contour was noted in five (62.5%) eyes at the final follow-up. Conclusions: The use of sub-PFO injection of OVD in MHRD surgery could stabilize inverted ILM flaps, achieve good anatomical results and improve postoperative BCVA.

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Internal limiting membrane transplantation for unclosed and large macular holes

Abstract: Transplantation of autologous ILM is an effective addition to the surgical options for large macular holes after failed surgeries with ILM removal.

Cited by 67 publications

References 14 publications

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

A human Amniotic Membrane plug to manage high myopic macular hole associated with retinal detachment

Autologous Neurosensory Retinal Transplantation for Unclosed and Large Macular Holes

Sub-perfluoro-n-octane injection of ocular viscoelastic device assisted inverted internal limiting membrane flap for macular hole retinal detachment surgery: a novel technique

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