Internal initiation: IRES elements of picornaviruses and hepatitis c virus

Jang, Sung Key

doi:10.1016/j.virusres.2005.11.003

Cited by 71 publications

(59 citation statements)

References 148 publications

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“…Cis-acting IRESs, exemplified in the RNA genomes of the picorna-and flaviviruses, feature complex higher order structure directing capindependent initiation in the interior of the viral RNA adjacent to a start codon 12,13 (Fig. 2).…”

Section: Bunyavirus N Protein Is a Translation Initiation Factormentioning

confidence: 99%

Bunyavirus N: eIF4F surrogate and cap-guardian

Panganiban¹,

Mir²

2009

Cell Cycle

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Section: Bunyavirus N Protein Is a Translation Initiation Factormentioning

confidence: 99%

Bunyavirus N: eIF4F surrogate and cap-guardian

Panganiban¹,

Mir²

2009

Cell Cycle

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“…The second most studied function of PTB is its role in internal ribosomal entry site (IRES)-mediated translation initiation of both cellular and viral mRNAs. IRESs are large RNA structures present in the 5'-untranslated regions (UTR) of some cellular mRNAs [43,44] and of many viral mRNAs [45] (Fig. 2).…”

Section: The Many Functions Of Polypyrimidine Tract Binding Proteinmentioning

confidence: 99%

Structure-function relationships of the polypyrimidine tract binding protein

Auweter

Allain

2007

Cell. Mol. Life Sci.

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Abstract. The polypyrimidine tract binding protein (PTB) is a 58-kDa RNA binding protein involved in multiple aspects of mRNA metabolism including splicing regulation, polyadenylation, 3'end formation, internal ribosomal entry site-mediated translation, RNA localization and stability. PTB contains four RNA recognition motifs (RRMs) separated by three linkers. In this review we summarize structural information on PTB in solution that has been gathered during the past 7 years using NMR spectroscopy and small-angle X-ray scattering. The structures of all RRMs of PTB in their free state and in complex with short pyrimidine tracts, as well as a structural model of PTB RRM2 in complex with a peptide, revealed unusual structural features that provided new insights into the mechanisms of action of PTB in the different processes of RNA metabolism and in particular splicing regulation.

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“…Type II IRESs require many of the canonical translation initiation factors. eIF4G, eIF4A and eIF4B have been demonstrated to interact with the SL J/K/L regions of the type II IRESs, with mutations to these domains causing reductions in IRES activity (Jang, 2006). As mentioned above, viral IRESs often utilize ITAFs, which further enhance translation in the absence of the canonical translation factors.…”

Section: Type II Iressmentioning

confidence: 99%

“…This is quite apparent in picornaviruses because their viral mRNA does not contain a cap structure at the 5'end. Also, its IRES located in the 5'UTR recruits ribosomes and other factors, which then scan to reach the initiation codon without the requirement of the eIF4E (Jang, et al, 2009, Jang, 2006. IRES containing viruses are able to benefit from the ER stress response, enhancing their own protein synthesis while also enhancing their self-defense capability.…”

Section: Introductionmentioning

confidence: 99%