Internal-Illumination Photoacoustic Tomography Enhanced by a Graded-Scattering Fiber Diffuser

Li, Mucong; Vu, Tri; Sankii, Georgy; Winship, Brenton; Boydston, Kohldon; Terry, Russell; Zhong, Pei; Yao, Junjie

doi:10.1109/tmi.2020.3027199

Cited by 12 publications

(12 citation statements)

References 71 publications

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“…This setup provides a good solution for the clinical translation of PA imaging to guide RF ablation. Another study from Li et al [ 149 ] proposed a new strategy to enhance the internal illumination based on the designed graded-scattering fiber diffuser, which may be applied to improve the optical illumination for PA imaging of ablation progression.…”

Section: Pa Imaging and DL Techniques In Cardiologymentioning

confidence: 99%

Advanced Ultrasound and Photoacoustic Imaging in Cardiology

Awasthi

Rad

et al. 2021

Sensors

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Cardiovascular diseases (CVDs) remain the leading cause of death worldwide. An effective management and treatment of CVDs highly relies on accurate diagnosis of the disease. As the most common imaging technique for clinical diagnosis of the CVDs, US imaging has been intensively explored. Especially with the introduction of deep learning (DL) techniques, US imaging has advanced tremendously in recent years. Photoacoustic imaging (PAI) is one of the most promising new imaging methods in addition to the existing clinical imaging methods. It can characterize different tissue compositions based on optical absorption contrast and thus can assess the functionality of the tissue. This paper reviews some major technological developments in both US (combined with deep learning techniques) and PA imaging in the application of diagnosis of CVDs.

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Section: Pa Imaging and DL Techniques In Cardiologymentioning

confidence: 99%

Advanced Ultrasound and Photoacoustic Imaging in Cardiology

Awasthi

Rad

et al. 2021

Sensors

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“…However, both types of illumination typically cover only a small field of view, mostly because of the limited beam-diverging distance between the fiber tip and the tissue surface. 92 Reproduced with permission from. 49,50,87,92 To illuminate a larger field of view, such as the adult kidney, Li et al have proposed to use an optical fiber diffuser for internal light delivery in PAT.…”

Section: Novel Pat Systems To Improve Penetration Depthmentioning

confidence: 99%

“…92 Reproduced with permission from. 49,50,87,92 To illuminate a larger field of view, such as the adult kidney, Li et al have proposed to use an optical fiber diffuser for internal light delivery in PAT. 49 Two types of fiber diffusers have been explored for this purpose: radial-emission and frontalemission diffusers.…”

Section: Novel Pat Systems To Improve Penetration Depthmentioning

confidence: 99%

“…The diffuser is made of scattering medium, such as intralipid and TiO 2 , with increasing concentrations from the fiber tip so as to generate a homogeneous light distribution in the nearby tissues. 91,92 Figure 2C and D show the representative designs of radial-emission and frontalemission diffusers. As an example, Figure 2D shows a frontal-emission diffuser made of segmented agar mixed with intralipid.…”

Section: Novel Pat Systems To Improve Penetration Depthmentioning

confidence: 99%

“…(d) A representative frontal-emission diffuser fiber diffuser. (e-f) B-mode ultrasound image (e) and PA image (f) of the blood-filled tube on an ex vivo pig kidney overlaid by an 8-cm-thick layer of fresh chicken breast tissue 92. Reproduced with permission from 49,50,87,92.…”

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Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Nyayapathi

Kilian

et al. 2020

Mol Imaging

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Photoacoustic tomography (PAT) has become increasingly popular for molecular imaging due to its unique optical absorption contrast, high spatial resolution, deep imaging depth, and high imaging speed. Yet, the strong optical attenuation of biological tissues has traditionally prevented PAT from penetrating more than a few centimeters and limited its application for studying deeply seated targets. A variety of PAT technologies have been developed to extend the imaging depth, including employing deep-penetrating microwaves and X-ray photons as excitation sources, delivering the light to the inside of the organ, reshaping the light wavefront to better focus into scattering medium, as well as improving the sensitivity of ultrasonic transducers. At the same time, novel optical fluence mapping algorithms and image reconstruction methods have been developed to improve the quantitative accuracy of PAT, which is crucial to recover weak molecular signals at larger depths. The development of highly-absorbing near-infrared PA molecular probes has also flourished to provide high sensitivity and specificity in studying cellular processes. This review aims to introduce the recent developments in deep PA molecular imaging, including novel imaging systems, image processing methods and molecular probes, as well as their representative biomedical applications. Existing challenges and future directions are also discussed.

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Development of a High‐Performance, Anti‐Fouling Optical Diffuser Inspired by Morpho Butterfly's Nanostructure

Yamashita

Taniguchi

Hattori

et al. 2023

Advanced Optical Materials

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The realization of high‐performance, anti‐fouling optical diffusers is crucial for various light applications. However, this remains a major challenge for conventional diffusers because of the optical inefficiency of multiple scattering and/or surface reliefs vulnerable to contamination. Inspired by the disordered nanostructure of Morpho butterflies that enables the simultaneous fulfillment of wide‐angle diffraction, low color dispersion, and superhydrophobic self‐cleaning ability due to the lotus effect, this study demonstrates a novel Morpho‐type diffuser with high optical performance and anti‐fouling properties. Surface nanopatterns of the diffuser are newly designed to realize homogeneous light diffusion, combined with the suitable material selection of polydimethylsiloxane (PDMS) to induce the lotus effect. Consequently, the following properties are simultaneously achieved: i) high transmittance ≈90%; ii) wide‐angle diffusion (full width at half maximum ≈80°) with high spatial uniformity; iii) low dispersion; iv) high controllability of anisotropy; and v) anti‐fouling properties. Moreover, vi) the applicability of surface protection is demonstrated by exploiting the high flexibility/adhesivity of PDMS. These capabilities surpass other diffusers, and therefore the presented diffuser is promising for a wide range of applications such as lighting, displays, daylight harvesting, optoelectronics, and medicine.

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Internal-Illumination Photoacoustic Tomography Enhanced by a Graded-Scattering Fiber Diffuser

Cited by 12 publications

References 71 publications

Advanced Ultrasound and Photoacoustic Imaging in Cardiology

Advanced Ultrasound and Photoacoustic Imaging in Cardiology

Sound Out the Deep Colors: Photoacoustic Molecular Imaging at New Depths

Development of a High‐Performance, Anti‐Fouling Optical Diffuser Inspired by Morpho Butterfly's Nanostructure

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