Internal exposure to pollutants and body size in Flemish adolescents and adults: Associations and dose–response relationships

Dhooge, Willem; Hond, Elly Den; Koppen, Gudrun; Bruckers, Liesbeth; Nelen, Vera; Mieroop, Els Van de; Bilau, Maaike; Croes, Kim; Baeyens, Willy; Schoeters, Greet; Larebeke, Nicolas Van

doi:10.1016/j.envint.2010.01.005

Cited by 77 publications

(72 citation statements)

References 46 publications

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“…As described in detail by Dhooge et al (2010), a significant (Po0.001) and positive association was observed between serum HCB concentration and the aromatase index (T/E 2 ) in this study. These results are in line with the hypothesis that HCB might protect against gynecomastia by its inhibiting effect on aromatase.…”

Section: Discussionsupporting

confidence: 84%

“…Even non-monotonic associations have been described (Bonefeld-Jorgensen et al, 2001;Endo et al, 2003;Gregoraszczuk et al, 2003;Eskenazi et al, 2005). The positive association found by Dhooge et al (2010) between serum marker PCB levels and sex hormone levels for male adolescents in our study was much stronger at serum PCB concentrations below the median concentration of 0.92 nmol/l. As almost all male adolescents participating in the pilot biomonitoring study had marker PCB serum levels that were superior to 0.92 nmol/l, part of the contradiction between the earlier findings and ours might be due to this marked difference in range of internal exposures.…”

Section: Discussioncontrasting

confidence: 57%

“…All public information on the project can be found on the website http:// www.milieu-en-gezondheid.be/English/index.html. Schroijen et al (2008) reported on the internal exposure of 14-to 15-year-old adolescents to pollutants measured in blood, serum or urine, and Dhooge et al (2010) reported on the hormone levels and body size of these adolescents in relation to internal exposure to environmental pollutants.…”

Section: Introductionmentioning

confidence: 99%

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Internal exposure to pollutants and sexual maturation in Flemish adolescents

Hond

Dhooge

Bruckers

et al. 2010

J Expo Sci Environ Epidemiol

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Flanders is densely populated with much industry and intensive farming. Sexual maturation of adolescents (aged 14-15 years) was studied in relation to internal exposure to pollutants. Serum levels of pollutants and sex hormones were measured in 1679 participants selected as a random sample of the adolescents residing in the study areas. Data on sexual development were obtained from the medical school examination files. Self-assessment questionnaires provided information on health, use of medication and lifestyle factors. In boys, serum levels of hexachlorobenzene (HCB), p,p 0 -DDE and polychlorinated biphenyls (sum of marker PCB138, 153 and 180) were significantly and positively associated with pubertal staging (pubic hair and genital development). Higher levels of serum HCB and blood lead were associated with, respectively, a lower and a higher risk of gynecomastia. In girls, significant and negative associations were detected between blood lead and pubic hair development; higher exposure to PCBs was significantly associated with a delay in timing of menarche. Environmental exposures to pollutants at levels actually present in the Flemish population are associated with measurable effects on pubertal development. However, further understanding of toxic mode of action and sensitive windows of exposure is needed to explain the current findings.

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

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Internal exposure to pollutants and sexual maturation in Flemish adolescents

Hond

Dhooge

Bruckers

et al. 2010

J Expo Sci Environ Epidemiol

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“…Dhooge et al measured the urinary level of cadmium in 14-to 15 -year -old males and females and found that higher levels of cadmium negatively affected children's growth (10).…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Effects of Environmental Pollutants, Chemical Factors, and Climate Changes on Children’s Height

et al. 2018

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Objective: Height is a multifactorial characteristic affected by genetics, hormonal and environmental factors. The aim of this study was to systematically review the effects of environmental pollutants, chemical factors, and climate changes on children and adolescents' height.Methods: This study searched scientific databases including PubMed, ISI Web of Science, and Scopus using key words such as "Environmental Pollution", "Climate Change", "Growth", "Body Height", "Child and adolescent development", and their combination. By removing duplicates, relevant papers were selected in three phases. This review included studies that were conducted among children and adolescents up to the age of 18. After the quality assessment, data was extracted by a reviewer and rechecked by another one. The authors summarized information of 52 articles about the possible effects of environmental factors and climate change on height. Articles were divided to four categories, including air, soil, water pollutants, and climate changes.

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“…The impact of prenatal exposure increasing the risk of obesity has been demonstrated in humans for maternal tobacco smoke [29]; dichlorodiphenyldichloroethylene (DDE), the metabolite of dichlorodiphenyltrichloroethane (DDT) [30,31]; hexachlorobenzene [32]; and polychlorinated biphenyls [33,34]. There is some indication that different polychlorinated biphenyl congeners may have different associations, and that sex and height may be confounders [35]. Animal studies have demonstrated that environmental chemicals, especially those with endocrine-disrupting activity, act prenatally on adipocyte precursors to increase the number of adipocytes; to modify the way adipocytes store and metabolise fat postnatally, especially in the presence of a high-fat diet; and increase the secretion of pro-inflammatory cytokines from adipocytes [28,36,37].…”

Section: Obesity and Type II Diabetesmentioning

confidence: 99%

Early-life risk factors for chronic nonrespiratory diseases

et al. 2014

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We have witnessed a change in disease patterns contributing to the global burden of disease, with a shift from early childhood deaths due to the classic infectious communicable diseases to years lived with disability from chronic noncommunicable diseases. In both developing and developed countries, the years lived with disability attributable to chronic disease have increased: cardiovascular diseases by 17.7%; chronic respiratory disease by 8.5%; neurological conditions by 12.2%; diabetes by 30.0%; and mental and behavioural disorders by 5.0% over the past 20 years. Recognition of the contribution made by adverse environmental exposures in early life to noncommunicable diseases in later life is increasing. These earlylife exposures appear to contribute to both chronic respiratory and chronic nonrespiratory diseases. In this State of the Art article, we aim to examine early-life environmental exposures that have an epidemiological association with chronic nonrespiratory diseases, such as obesity and type II diabetes, cardiovascular disease, and neurocognitive and behavioural problems. We will highlight the potential overlap in environmental risks with respiratory diseases, and point out knowledge gaps and research opportunities. @ERSpublications Respiratory diseases are linked to obesity/diabetes/metabolic syndrome, CVD and neurocognitive/behavioural disorders

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Internal exposure to pollutants and body size in Flemish adolescents and adults: Associations and dose–response relationships

Cited by 77 publications

References 46 publications

Internal exposure to pollutants and sexual maturation in Flemish adolescents

Internal exposure to pollutants and sexual maturation in Flemish adolescents

A Systematic Review of the Effects of Environmental Pollutants, Chemical Factors, and Climate Changes on Children’s Height

Early-life risk factors for chronic nonrespiratory diseases

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