Internal dosimetry: towards harmonisation and coordination of research

Abstract

The CONRAD Project is a Coordinated Network for Radiation Dosimetry funded by the European Commission 6th Framework Programme. The activities developed within CONRAD Work Package 5 ('Coordination of Research on Internal Dosimetry') have contributed to improve the harmonisation and reliability in the assessment of internal doses. The tasks carried out included a study of uncertainties and the refinement of the IDEAS Guidelines associated with the evaluation of doses after intakes of radionuclides. The implementation and quality assurance of new biokinetic models for dose assessment and the first attempt to develop a generic dosimetric model for DTPA therapy are important WP5 achievements. Applications of voxel phantoms and Monte Carlo simulations for the assessment of intakes from in vivo measurements were also considered. A Nuclear Emergency Monitoring Network (EUREMON) has been established for the interpretation of monitoring data after accidental or deliberate releases of radionuclides. Finally, WP5 group has worked on the update of the existing IDEAS bibliographic, internal contamination and case evaluation databases. A summary of CONRAD WP5 objectives and results is presented here.

The European radiation dosimetry group – Review of recent scientific achievements

“…Within the CONRAD project (Lopez et al, 2008) EURADOS initiated the development of a model describing the biokinetics of actinides following decorporation therapy with DTPA (Breustedt et al 2009). The current model used by WG7 includes three separate compartmental models describing the behavior of a) the actinide, b) the injected forms of DTPA and c) the complexes of actinide and DTPA formed in-vivo.…”

The Conrad Approach to Biokinetic Modeling of Dtpa Decorporation Therapy

“…Several scientists who were not directly involved in the CONRAD project joined the group for discussion and work on the decorporation model presented here. The work of the task group was also devoted to other topics which have been described elsewhere (Lopez et al 2008a and b;Nosske et al 2008;Giussani et al 2008).…”