Internal dose assessment of 210Po using biokinetic modeling and urinary excretion measurement

Li, Wei Bo; Gerstmann, Udo; Giussani, A.; Oeh, Uwe; Paretzke, H. G.

doi:10.1007/s00411-007-0133-0

Cited by 12 publications

(11 citation statements)

References 17 publications

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“…95 On the basis of the calculated organ absorbed doses and different assumptions regarding blood absorption and lethal absorbed doses for red bone marrow, kidneys, and liver, the minimum estimated amount of 210 Po which led to the death of A. Litvinenko is estimated to range from 27 to 1,408 MBq, about 0.2 to 8.5 μg, if only 210 Po was used as a poison. 96 These estimations are in agreement with animal data on the effects of 210 Po. 78,92 The data obtained for a number of mammalian species are consistent with death occurring within 20 days of an uptake to blood of about 1−4 MBq/kg.…”

Section: ■ Deterministic Effectssupporting

confidence: 84%

Review of Chemical and Radiotoxicological Properties of Polonium for Internal Contamination Purposes

Ansoborlo

Bérard

Auwer

et al. 2012

Chem. Res. Toxicol.

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The discovery of polonium (Po) was first published in July, 1898 by P. Curie and M. Curie. It was the first element to be discovered by the radiochemical method. Polonium can be considered as a famous but neglected element: only a few studies of polonium chemistry have been published, mostly between 1950 and 1990. The recent (2006) event in which (210)Po evidently was used as a poison to kill A. Litvinenko has raised new interest in polonium. 2011 being the 100th anniversary of the Marie Curie Nobel Prize in Chemistry, the aim of this review is to look at the several aspects of polonium linked to its chemical properties and its radiotoxicity, including (i) its radiochemistry and interaction with matter; (ii) its main sources and uses; (iii) its physicochemical properties; (iv) its main analytical methods; (v) its background exposure risk in water, food, and other environmental media; (vi) its biokinetics and distribution following inhalation, ingestion, and wound contamination; (vii) its dosimetry; and (viii) treatments available (decorporation) in case of internal contamination.

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Section: ■ Deterministic Effectssupporting

confidence: 84%

Review of Chemical and Radiotoxicological Properties of Polonium for Internal Contamination Purposes

Ansoborlo

Bérard

Auwer

et al. 2012

Chem. Res. Toxicol.

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“…Their data showed that for most of the investigated individuals with increased urinary 210 Po excretion, approximately 7 days after consumption, 210 Po excretion was decreased almost to background level. It should be added, however, that such a sharp decline in urinary 210 Po excretion after ingestion does not follow from biokinetic models, as evidenced by Li et al (2008).…”

Section: Methodsmentioning

confidence: 92%

Variation of 210Po daily urinary excretion for male subjects at environmental level

Hölgye

Hýža

Mihalík

et al. 2015

Radiat Environ Biophys

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(210)Po was determined in 24-h urine of seven healthy males from Prague, Czech Republic, for ten consecutive days. The results show that for each volunteer, the urinary excretion of (210)Po changed only little from day to day in the studied time period. For two volunteers, the difference in the daily excreted (210)Po activity for two consecutive days was not significant, given the 95% confidence interval (two sigma) of the activity measurements. The same is valid for the excretion data of the other volunteers, except for some days where the differences were slightly higher. The range of daily urinary excretion of (210)Po of each volunteer in the studied time period was quite narrow. Among the volunteers, the maximum daily urinary excretion value of (210)Po was at most about a factor of 2.5 higher than the lowest excretion value. An attempt to explain the observed small inter-individual variability of (210)Po excretion in daily urine is made.

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“…Biokinetic and dosimetric models were used to retrospectively estimate the possible intake of radionuclide 210 Po for the ex-Russian spy Alexander Litvinenko. 119)…”

Section: Internal Exposure Monitoringmentioning

confidence: 99%

Internal Dosimetry

2018

Hoken Butsuri

Self Cite

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Protection (ICRP) established a committee on permission internal exposure. Natural and man-made radionuclides can enter human body, cause damage effect and lead to health risk; on the other hand, radionuclides can cure cancers and other noncancer diseases by irradiating the malignant cells and tissues. The radiation doses delivered to the tissues and organs are dose assessment of internally deposited radionuclides is reviewed. After brief introduction of interactions and effects of radiation, the biokinetic models developed by ICRP for incorporation of radionuclides in humans are described. Then, the dosimetric formula generalized by ICRP and Committee on Medical Internal Radiation Dose (MIRD) is presented. Treatment of decay products and uncertainty analysis in internal dosimetry are especially addressed. Moreover, applications of internal dosimetry in radiation protection, internal exposure monitoring, radon inhalation dosimetry and nuclear medicine are presented with several calculation examples. At last, the future perspective of internal dosimetry is discussed. In an appendix basic internal dosimetric quantities are provided.

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Internal dose assessment of 210Po using biokinetic modeling and urinary excretion measurement

Cited by 12 publications

References 17 publications

Review of Chemical and Radiotoxicological Properties of Polonium for Internal Contamination Purposes

Review of Chemical and Radiotoxicological Properties of Polonium for Internal Contamination Purposes

Variation of 210Po daily urinary excretion for male subjects at environmental level

Internal Dosimetry

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