Internal consistency and stability of the CANTAB neuropsychological test battery in children.

Syväoja, Heidi; Tammelin, Tuija; Ahonen, Timo; Räsänen, Pekka; Tolvanen, Asko; Kankaanpää, Anna; Kantomaa, Marko T.

doi:10.1037/a0038485

Cited by 44 publications

(34 citation statements)

References 38 publications

(93 reference statements)

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“…The CANTAB consists of a collection of well‐validated, sensitive, and reliable touchscreen tests measuring cognitive function (Lowe & Rabbitt, ). The reaction time tasks in particular have high reliability (Syvaoja et al, ). SRT and CRT are both measures of response speed and general alertness.…”

Section: Methodsmentioning

confidence: 99%

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Disrupted network connectivity in pediatric brain tumor survivors is a signature of injury

Gauvreau

Lefebvre

Bells

et al. 2019

J of Comparative Neurology

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Cognition is compromised in pediatric brain tumor survivors but the neurophysiological basis of this compromise remains unclear. We hypothesized that reduced neural synchronization across brain networks is involved. To test this, we evaluated group differences using a retrospective cohort comparison design between 24 pediatric brain tumor survivors [11.81 ± 3.27)] and 24 age matched healthy children [12.04 ± 3.28)] in functional connectivity within a cerebellar network to examine local effects of the tumor, a whole brain network to examine diffuse effects of treatment (i.e., chemotherapy and radiation), and across multiple intrinsic connectivity networks. Neural activity was recorded during magnetoencephalography scanning while participants were at rest and functional connectivity within networks was measured using the phase lag index. We corroborated our findings using a computational model representing the local tumor effects on neural synchrony. Compared to healthy children, pediatric brain tumor survivors show increased functional connectivity for theta and beta frequency bands within the cerebellar network and increased functional connectivity for the theta band within the whole brain network that again localized to the cerebellum. Computational modeling showed that increased synchrony in the theta bad is observed following local clustering as well as sparse interarea brain connectivity. We also observed increased functional connectivity for the alpha frequency band in the ventral attention network and decreased functional connectivity within the gamma frequency band in the motor network within paedatric brain tumor survivors versus healthy children. Notably, increased gamma functional connectivity within the motor network predicted decreased reaction time on behavioral tasks in pediatric brain tumor survivors. Disrupted network synchrony may be a signature of neurological injury and disease.

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Section: Methodsmentioning

confidence: 99%

“…2.9 | Assessment of information processing speed (Lowe & Rabbitt, 1998). The reaction time tasks in particular have high reliability (Syvaoja et al, 2015). SRT and CRT are both measures of response speed and general alertness.…”

Section: Computational Modelingmentioning

confidence: 99%

Disrupted network connectivity in pediatric brain tumor survivors is a signature of injury

Gauvreau

Lefebvre

Bells

et al. 2019

J of Comparative Neurology

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“…Future longitudinal designs including adolescents and adults are needed to more fully understand developmental trajectories of the brain‐cognition relationship with planning ability. Finally, the test–retest stability of the number of SOC trials solved with the minimum number of moves has been found to be relatively low in previous studies in adults (Lowe & Rabbitt, ) and children (Syvaoja et al, ). This study did not employ the number of SOC trials solved with the minimum number of moves.…”

Section: Discussionmentioning

confidence: 78%

Cerebellar development and its mediation role in cognitive planning in childhood

Kipping

Xie

Qiu

2018

Human Brain Mapping

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Recent evidence suggests that the cerebellum contributes not only to the planning and execution of movement but also to the high-order cognitive planning. Childhood is a critical period for development of the cerebellum and cognitive planning. This study aimed (a) to examine the development of cerebellar morphology and microstructure and (b) to examine the cerebellar mediation roles in the relationship between age and cognitive planning in 6- to 10-year-old children (n = 126). We used an anatomical parcellation to quantify cerebellar regional gray matter (GM) and white matter (WM) volumes, and WM microstructure, including fractional anisotropy (FA) and mean diffusivity (MD). We assessed planning ability using the Stockings of Cambridge (SOC) task in all children. We revealed (a) a measure-specific anterior-to-posterior gradient of the cerebellar development in childhood, that is, smaller GM volumes and greater WM FA of the anterior segment of the cerebellum but larger GM volumes and lower WM FA in the posterior segment of the cerebellum in older children; (b) an age-related improvement of the SOC performance at the most demanding level of five-move problems; and (c) a mediation role of the lateral cerebellar WM volumes in age-related improvement in the SOC performance in childhood. These results highlight the differential development of the cerebellum during childhood and provide evidence that brain adaptation to the acquisition of planning ability during childhood could partially be achieved through the engagement of the lateral cerebellum.

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“…It was concluded that the CANTAB may be very useful for children with weak verbal skills due to its low demand on language proficiency. A recent study found that the reaction time subtest was the most reliable and stable test of the subtests with stability found for the visual memory, reaction time, and visual information processing subtests (Syvaoja et al, 2015). It was found that the set shifting measure and the spatial recognition memory subtests were not reliable or stable with typically developing children.…”

Section: General Comprehensive and Specific Neurodevelopment Tests (mentioning

confidence: 99%

“…A recent article indicated some difficulty with reliability and stability of this measure with typically developing children in a HIMC (Syvaoja et al, 2015). For this reason the use of CANTAB in LMIC suggests that this instrument may not be appropriate.…”

Section: General Comprehensive and Specific Neurodevelopment Tests (mentioning

confidence: 99%

Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries

Semrud‐Clikeman

Romero

Prado

et al. 2016

Child Neuropsychology

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Diseases affecting millions of children in low and middle-income countries (LMIC), such as malnutrition, micronutrient deficiency, malaria, and HIV, can lead to adverse neurodevelopmental outcomes. Thus, a key health outcome in children is neurodevelopmental status. We reviewed the neurodevelopmental screening and testing measures most commonly utilized in LMIC, and created a matrix to help researchers and clinicians determine which measures may be most useful for various LMIC inquiries. The matrix was based on an internet literature review of 114 publications from January 1998 to May 2016 reporting the psychometric properties of instruments tested in LMIC children. Measures were classified as screening tests or more detailed tests that included both comprehensive batteries of general development and tests of specific domains. We have also had two experts as well as the authors review this paper for completeness. We provide an overview of tests used to date, including the benefits and drawbacks of each test, to provide researchers and developmental clinicians with a way to decide which tests may be best suited to their developmental assessment goals. Remarkable progress has been made in neurodevelopmental testing in children in LMIC over the past two decades but there remains a need for additional research in this area to develop new tests, better evaluate and adapt current tests, and assess test validity and reliability across cultures.

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Internal consistency and stability of the CANTAB neuropsychological test battery in children.

Cited by 44 publications

References 38 publications

Disrupted network connectivity in pediatric brain tumor survivors is a signature of injury

Disrupted network connectivity in pediatric brain tumor survivors is a signature of injury

Cerebellar development and its mediation role in cognitive planning in childhood

Selecting measures for the neurodevelopmental assessment of children in low- and middle-income countries

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