AMONG the first to call attention to the occurrence of arterial thrombosis as an etiology of infantile and childhood hemiplegia was Gowers in 1888,1 Osler in 1889 -1899 ,2 and Freud in 1897 Though the frequency is far less common in children than adults, a number of case reports and reviews have been published,4-20 particularly within the past 20 years.In this report, we propose to consider briefly the general problem of arterial occlusive disease affecting the brain in children, with emphasis on occlusions within the cervical portion of the carotid system. Also, we will give an example of sudden, spontaneous occlusion of the cervical internal carotid artery due to a fresh, soft thrombus in a child in which early angiography, arteriotomy, and thrombectomy allowed restitution of flow.
Report of a CaseA 2-year-old white boy was admitted to St. Louis Children's Hospital approximately 12 hours after the sudden onset of a right hemiplegia and aphasia without loss of conscious¬ ness. During the six days preceding admission he had fever, anorexia, mild vomiting, diarrhea, and an upper respiratory infection, which prompted admission to a local hospital. The next morning the neurological symptoms ap¬ peared. A spinal puncture showed clear fluid with seven red blood cells (RBCs) and four lymphocytes, protein of 39 mg/100 cc, sugar of 87 mg/100 cc, and chloride of 91 mg/100 cc. Initial cerebrospinal fluid (CSF) pressure was unknown. There was no familial disease and no history of rheumatic fever, cardiac disease, or blood dyscrasia.Upon admission to St Louis Children's Hos¬ pital later that day, the child was conscious and responsive. He appeared anemic and moderate¬ ly dehydrated. The temperature was 98.6 F (37 C) and the pulse was 200 beats per minute; blood pressure was 100/60 mm Hg. The head was normal; there were no contusions of the head, neck, or torso, and no nuchal rigidity. Conjunctivae and sclerae were clear; there was minimal tonsillar enlargement and mild cervi¬ cal lymphadenopathy. A tachycardia was present without murmur or evident cardiomegaly. The liver was palpable two fingerbreadths below the right costal margin. This child was alert, but irritable, and was aphasie. Movement on the left side was normal. There was a right hemiplegia with hyperreflexia, extensor toe sign on the right, a right homonymous field deficit, and a right central facial paralysis. Funduscopic examination was normal.A lumbar puncture on admission revealed an opening pressure of 116 mm saline with clear fluid, containing ten RBCs and four lympho¬ cytes. Protein, sugar, and cultures of the CSF were normal. Hemoglobin was 6.6 with a hematocrit of 25%. Chest film revealed a left lower lobe pneumonia; skull films were normal. The electrocardiogram indicated a supraventricular tachycardia with a Wolf-Parkinson-White conduction pattern.Shortly after admission he was placed on antibiotics and given 150 cc of packed RBCs. His pulse increased to 250, and he developed dyspnea. It was felt that he was in congestive heart failure and was digital...