Internal carotid artery occlusion associated with Mycoplasma pneumoniae infection

Visudhiphan, Pongsakdi; Chiemchanya, Surang; Sirinavin, Sayomporn

doi:10.1016/0887-8994(92)90078-d

Cited by 29 publications

(23 citation statements)

References 8 publications

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“…The middle cerebral arteries are most often affected [Fu et al, 1998;Leonardi et al, 2005;Mulder & Spierings, 1987;Parker et al, 1981;Senda et al, 2010;Sotgiu et al, 2003], though the internal carotid arteries are affected in a few cases Tanir et al, 2006;Visudhiphan et al, 1992]. Although the presence of systemic hypercoagulable state has been reported in a few cases, evidenced by disseminated intravascular coagulation [Mulder & Spierings, 1987] or by the production of antiphospholipid (anticardiolipin) antibodies [Senda et al, 2010;Snowden et al, 1990;Tanir et al, 2006], most cases occur in the absence of such conditions.…”

Section: Strokementioning

confidence: 99%

“…Stroke can occur in children [Fu et al, 1998;Lee et al, 2009;Leonardi et al, 2005;Ovetchkine et al, 2002;Parker et al, 1981;Tanir et al, 2006;Visudhiphan et al, 1992] as well as in adults [Mulder & Spierings, 1987;Padovan et al, 2001;Senda et al, 2010;Snowden et al, 1990;Sočan et al, 2001;Sotgiu et al, 2003]. The middle cerebral arteries are most often affected [Fu et al, 1998;Leonardi et al, 2005;Mulder & Spierings, 1987;Parker et al, 1981;Senda et al, 2010;Sotgiu et al, 2003], though the internal carotid arteries are affected in a few cases Tanir et al, 2006;Visudhiphan et al, 1992].…”

Section: Strokementioning

confidence: 99%

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Mycoplasma pneumoniae as an Under- Recognized Agent of Vasculitic Disorders

Narita¹

2011

Advances in the Etiology, Pathogenesis and Pathology of Vasculitis

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Section: Strokementioning

confidence: 99%

Section: Strokementioning

confidence: 99%

Mycoplasma pneumoniae as an Under- Recognized Agent of Vasculitic Disorders

Narita¹

2011

Advances in the Etiology, Pathogenesis and Pathology of Vasculitis

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“…18 Commonly reported neurological complications of mycoplasma pneumoniae include seizures, coma and meningeal signs 7 while less common complications include status epilepticus with PLEDs, 20 encephalitis lethargica 21 and stroke-like syndromes. 22 Most reports of MPAE have described diffuse cerebral involvement, but in our experience focal manifestations are at least as common. We report a second patient (patient 3) with ringenhancing lesions on CT, a finding first reported by Walker 18 who was also unable to suggest a pathogenesis for the presence of cystic lesions in this condition.…”

Section: Patientmentioning

confidence: 96%

The Focal Encephalopathies Associated with Mycoplasma Pneumoniae

We³

1993

Can. j. neurol. sci.

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Five patients with evidence of focal encephalopathy are reported. In each case, evidence of mycoplasma pneumoniae infection was detected. No patient improved with conventional antibiotic therapy, but in three subjects, rapid and complete recovery did occur contemporaneously with the administration of high dose steroid therapy. It is suggested that focal as well as diffuse cerebral or cerebellar lesions may occur as manifestations of auto-immune disease complicating mycoplasmal infections in young people and that this illness may be designated as acute mycoplasmaassociated encephalopathy. RESUME: Encephalopathies focales a mycoplasma pneumoniae. Nous rapportons les cas de cinq patients prgsentant une encSphalopathie focale. Dans chaque cas, des signes d'infection a Mycoplasma pneumoniae ont et£ detected. Aucun patient ne s'est ameliore sous antibiotherapie conventionnelle. Cependant, chez trois patients, une guerison rapide et complete a ete obtenue alors que le patient etait sous corticotherapie intensive. Nous suggerons que des lesions focales et des lesions diffuses peuvent survenir au niveau du cerveau ou du cervelet comme manifestations d'une maladie auto-immune compliquant l'infection a mycoplasme chez les jeunes et que cette maladie pourrait etre designee sous le nom d'encephalopathie aigue associee au mycoplasme.

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“…In addition, M. pneumoniae has also been detected in atherosclerotic specimens [11, 12, 13, 14]. Although M. pneumoniae is known to cause central nervous system diseases [5, 28, 31], specific association between M. pneumoniae and acute cerebrovascular disease was limited to case reports involving mainly younger patients [15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28]. …”

Section: Discussionmentioning

confidence: 99%

“…Specifically, a positive association between M. pneumoniae infection and cerebrovascular disease has also been reported [15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28]. These reports are limited to a number of clinical case studies involving mainly paediatric and younger patients.…”

Section: Introductionmentioning

confidence: 96%

<i>Mycoplasma pneumoniae</i> in Elderly Patients with Stroke

Ngeh¹,

Gupta²,

Goodbourn³

et al. 2004

Cerebrovasc Dis

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Background and Purpose: Previous studies have suggested certain infections as potential risk factors for stroke. Chlamydia pneumoniae, an atypical respiratory pathogen, has been linked to atherosclerotic vascular diseases. Mycoplasma pneumoniae, another atypical respiratory micro-organism, can rarely cause stroke. We investigated whether serological markers of M. pneumoniae infection were associated with acute stroke or transient ischaemic attack (TIA) in elderly patients. Methods: This case-control study was nested within the C-PEPS study – a case-control study on the seroprevalence of C. pneumoniae in elderly stroke and medical patients. Ninety-five incident cases of patients admitted consecutively with acute stroke or TIA, and 82 control subjects admitted concurrently with acute non-cardiopulmonary, non-infective disorders, were included in this study (both groups aged 65 years or older). Using commercial enzyme-linked immunosorbent assay (ELISA) kits, the presence of M. pneumoniae immunoglobulins IgA, IgG and IgM in patients’ sera was determined. Results: The seroprevalence of M. pneumoniae IgA, IgG and IgM in the stroke or TIA group (median age = 80) were 79, 61 and 6%, respectively. In the control group (median age = 80), the seroprevalence of respective M. pneumoniae IgA, IgG and IgM were 84, 50 and 11%. Using a logistic regression statistical model, adjusting for history of hypertension, smoking, diabetes mellitus, age and sex, history of ischaemic heart disease, and ischaemic electrocardiogram, the odds ratios of having a stroke or TIA in relation to M. pneumoniae IgA, IgG and IgM were 0.63 (95% confidence interval (CI) = 0.26–1.52, p = 0.31), 1.32 (95% CI = 0.66–2.64, p = 0.43) and 0.52 (95% CI = 0.14–1.92, p = 0.32), respectively. Conclusions: The study showed a high seroprevalence of M. pneumoniae in an elderly hospital population, using ELISA. Although the study ruled out M. pneumoniae seropositivity as a major risk factor for stroke in this elderly population, a smaller effect could not be excluded due to the small sample size. Future larger studies may be required to determine the precise role of M. pneumoniae infection in the pathogenesis of different subtypes of ischaemic stroke, in all age groups, and in different ethnic populations.

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Internal carotid artery occlusion associated with Mycoplasma pneumoniae infection

Cited by 29 publications

References 8 publications

Mycoplasma pneumoniae as an Under- Recognized Agent of Vasculitic Disorders

Mycoplasma pneumoniae as an Under- Recognized Agent of Vasculitic Disorders

The Focal Encephalopathies Associated with Mycoplasma Pneumoniae

<i>Mycoplasma pneumoniae</i> in Elderly Patients with Stroke

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