Internal Bleeding Extending to the Retroperitoneum and Right Psoas With Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Abstract

Coronavirus disease 2019 (COVID-19 -severe acute respiratory syndrome coronavirus 2 {SARS-CoV-2}) infection has been associated with thromboembolic events and coagulopathy, leading to a surge in the use of anticoagulants. The dose and duration of therapy differ according to the followed protocol. Several case reports documented fatal bleeding as an adverse effect of anticoagulation.We report a case of nearly fatal retroperitoneal bleed in an otherwise healthy 60-year-old man who developed severe COVID-19 requiring ICU stay and mechanical ventilation. The development of retroperitoneal bleed led to a 50% drop in his hemoglobin. The patient happens to be a Jehovah's Witness, and the family refused blood transfusion, which added to the complexity of the situation.Anticoagulation is associated with a potential risk of fatal bleed in critically ill COVID-19 patients. There are different protocols of anticoagulation in the management of SARS-CoV-2. The risk of bleeding vs thrombosis should be weighed on a case-by-case basis. A high degree of suspicion, early intervention, and knowledge of alternatives to blood transfusion can improve outcomes.

Acute Bilateral Periorbital Edema in a Psychiatric Patient

“…7,8 Additionally, only 1 report of valproate-induced periorbital edema exists. 9 While we could not discern if only 1 or both agents caused the adverse reaction, both medications have been associated with periorbital edema. Ophthalmologists should be aware of this and other potential ocular adverse effects from psychiatric medications and consider it as part of their differential diagnosis in patients with bilateral periorbital and facial edema.…”