Intermuscular Fat, But Not Subcutaneous Fat, Correlated With Major Complications After Primary Total Hip Arthroplasty

Yu, Jianhua; Wang, Mingliang; Shen, Hao

doi:10.1016/j.acra.2022.09.014

Cited by 3 publications

(2 citation statements)

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“…17 Although there have been some studies exploring the prognostic value of thigh composition in elderly patients with hip fracture, they have focused on predicting surgical complication, functional recovery or mortality rather than adverse CV events. [18][19][20] Few studies have examined the relationship between thigh fat and muscle measurements and CV outcomes following hip fracture. Given that pelvic bone computed tomography (CT) is routinely performed as an initial examination for suspected hip fracture, this opportunistic measurement of thigh composition without additional exposure to radiation is practical and reliable.…”

Section: Introductionmentioning

confidence: 99%

“…Although there have been some studies exploring the prognostic value of thigh composition in elderly patients with hip fracture, they have focused on predicting surgical complication, functional recovery or mortality rather than adverse CV events 18–20 . Few studies have examined the relationship between thigh fat and muscle measurements and CV outcomes following hip fracture.…”

Section: Introductionmentioning

confidence: 99%

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Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture

Lee,

Kim,

2023

J cachexia sarcopenia muscle

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BackgroundAlthough sarcopenia has been recognized as a predictor of mortality in elderly patients with hip fracture, the association of thigh fat and muscle with cardiovascular (CV) outcome remains unclear. We examined the impact of computed tomography (CT)‐derived shape features of thigh fat and muscle on major adverse CV events (MACE) in elderly patients with hip fracture.MethodsWe conducted a retrospective analysis of consecutive patients aged ≥65 years who presented with hip fracture confirmed on pelvic bone CT scan and underwent hip fracture surgery at our institution from April 2019 to December 2021. The cross‐sectional area (CSA) and compactness (CM) of both the muscle and fat at the upper‐thigh level were calculated from two‐dimensional CT images using AVIEW Research (v1.1.38, Coreline Soft, Co. Ltd, Seoul, South Korea). The shape features of thigh fat and muscle were categorized into four groups based on the combination of CSA and CM: fat CSA (fat area [FA])/fat CM (FCM), muscle CSA (muscle area [MA])/muscle CM (MCM), FA/MCM and MA/FCM. In each of them, subjects were categorized into four subgroups: high CSA/high CM, high CSA/low CM, low CSA/high CM and low CSA/low CM. The primary outcome was MACE after 30 days of surgery, defined as a composite of all‐cause death, acute myocardial infarction, stroke or hospitalization for heart failure.ResultsOf 356 patients enrolled (median age, 82 years; 76.7% females), 72 (20.2%) had MACE over a median follow‐up of 13.1 months (ranges 5.9–21.0 months). Patients with MACE had a significantly lower median FA (193.7 vs. 226.2 cm2, P < 0.0001) and FCM (0.443 vs. 0.513, P = 0.001) compared with those without MACE, but no significant differences were found in MA, MCM and FA–MA ratio between the two groups. In a multivariate Cox regression analysis, low FA (<240.1 cm2) (adjusted hazard ratio [HR] 2.99, 95% confidence interval [CI] 1.39–6.44, P = 0.005) and low FCM (<0.477) (adjusted HR 2.00, 95% CI 1.10–3.63, P = 0.023) were associated with an increased risk of MACE. Among the shape phenotypes of thigh fat and muscle, the thigh fat phenotype of low FA/low FCM (adjusted HR 3.13, 95% CI 1.81–5.42, P < 0.0001 [reference, high FA/high FCM]) was found to be an independent predictor of MACE.ConclusionsIn elderly patients with fragility hip fracture, thigh CT‐derived measures of FA and FCM may provide useful prognostic information for predicting adverse CV outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture

Lee,

Kim,

2023

J cachexia sarcopenia muscle

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The role of subcutaneous fat and BMI in predicting surgical outcomes and patient reported outcomes in robotic-assisted total hip arthroplasty

DeClercq,

Sacchetti,

Coleman

et al. 2024

Journal of Orthopaedics

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Association of sex-specific abdominal adipose tissue with WHO/ISUP grade in clear cell renal cell carcinoma

Li,

Liao,

et al. 2023

Insights Imaging

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Objectives To explore the association between computed tomography (CT)-measured sex-specific abdominal adipose tissue and the pathological grade of clear cell renal cell carcinoma (ccRCC). Methods This retrospective study comprised 560 patients (394 males and 166 females) with pathologically proven ccRCC (467 low- and 93 high-grade). Abdominal CT images were used to assess the adipose tissue in the subcutaneous, visceral, and intermuscular regions. Subcutaneous fat index (SFI), visceral fat index (VFI), intermuscular fat index (IFI), total fat index (TFI), and relative visceral adipose tissue (rVAT) were calculated. Univariate and multivariate logistic regression analyses were performed according to sex to identify the associations between fat-related parameters and pathological grade. Results IFI was significantly higher in high-grade ccRCC patients than in low-grade patients for both men and women. For male patients with high-grade tumors, the SFI, VFI, TFI, and rVAT were significantly lower, but not for female patients. In both univariate and multivariate studies, the IFI continued to be a reliable and independent predictor of high-grade ccRCC, regardless of sex. Conclusions Intermuscular fat index proved to be a valuable biomarker for the pathological grade of ccRCC and could be used as a reliable independent predictor of high-grade ccRCC for both males and females. Critical relevance statement Sex-specific fat adipose tissue can be used as a new biomarker to provide a new dimension for renal tumor-related research and may provide new perspectives for personalized tumor management decision-making approaches. Key points • There are sex differences in distribution of subcutaneous fat and visceral fat. • The SFI, VFI, TFI, and rVAT were significantly lower in high-grade ccRCC male patients, but not for female patients. • Intermuscular fat index can be used as a reliable independent predictor of high-grade ccRCC for both males and females. Graphical Abstract

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Intermuscular Fat, But Not Subcutaneous Fat, Correlated With Major Complications After Primary Total Hip Arthroplasty

Cited by 3 publications

References 34 publications

Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture

Shape phenotype of thigh fat and muscle and risk of major adverse cardiovascular events after fragility hip fracture

The role of subcutaneous fat and BMI in predicting surgical outcomes and patient reported outcomes in robotic-assisted total hip arthroplasty

Association of sex-specific abdominal adipose tissue with WHO/ISUP grade in clear cell renal cell carcinoma

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