Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

Park, Wooram; Park, Sin Jung; Cho, Soojeong; Shin, Heejun; Jung, Youngae; Lee, Byeongdu; Na, Kun; Kim, Dong‐Hyun

doi:10.1021/jacs.6b04875

Cited by 58 publications

(48 citation statements)

References 44 publications

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“…The prepared polymer–protein conjugates showed an excellent biocompatibility while the temperature responsive function was maintained. In another study, Park et al fabricated a thermoswitchable biopolymeric PS (T‐PPS) by conjugating PS (pheophorbide‐a, PPb‐a) to a temperature responsive polymer backbone of hydroxypropyl cellulose (HPC) . The polymer undergoes a thermoswitchable conformational change from random‐coiled conformation to dehydrated fibrillar conformation between 40 and 50 o C and showed no significant cytotoxicity to cells.…”

Section: Chemical Design Of Dynamic Nanoparticle Assemblies For Biomementioning

confidence: 99%

Dynamic Nanoparticle Assemblies for Biomedical Applications

et al. 2017

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Designed synthesis and assembly of nanoparticles assisted by their surface ligands can create "smart" materials with programmed responses to external stimuli for biomedical applications. These assemblies can be designed to respond either exogenously (for example, to magnetic field, temperature, ultrasound, light, or electric pulses) or endogenously (to pH, enzymatic activity, or redox gradients) and play an increasingly important role in a diverse range of biomedical applications, such as biosensors, drug delivery, molecular imaging, and novel theranostic systems. In this review, the recent advances and challenges in the development of stimuli-responsive nanoparticle assemblies are summarized; in particular, the application-driven design of surface ligands for stimuli-responsive nanoparticle assemblies that are capable of sensing small changes in the disease microenvironment, which induce the related changes in their physico-chemical properties, is described. Finally, possible future research directions and problems that have to be addressed are briefly discussed.

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Section: Chemical Design Of Dynamic Nanoparticle Assemblies For Biomementioning

confidence: 99%

Dynamic Nanoparticle Assemblies for Biomedical Applications

et al. 2017

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“…An ideal PS should be easily soluble in water and easy to administer and should be able to accurately target the disease site . The low water solubility of PSs causes the molecules to aggregate together, limiting the generation of singlet oxygen . In this regard, various attempts have been made to chemically conjugate different types of hydrophilic biopolymers with hydrophobic PSs to improve water dispersion.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, various attempts have been made to chemically conjugate different types of hydrophilic biopolymers with hydrophobic PSs to improve water dispersion. Indeed, when polymeric PSs were synthesized using biopolymers such as polyethylene glycol (PEG), pluronic, pullulan, hyaluronic acid, and hydroxypropyl cellulose, an increase in both their solubility and ROS generation rate in aqueous conditions was reported. Various targeting ligands such as proteins, peptides, Aptamers, polysaccharides, and small molecules have also been used to improve the tumor‐targeting efficacy to disease sites .…”

Section: Introductionmentioning

confidence: 99%

Tumor‐Specific Aptamer‐Conjugated Polymeric Photosensitizer for Effective Endo‐Laparoscopic Photodynamic Therapy

Kim

Park

Kim

et al. 2019

Adv Funct Materials

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Recent advances in medical technology and endo-laparoscopic devices have enabled the treatment of gastrointestinal (GI) cancers to be minimally invasive through endo-laparoscopic photodynamic therapy (PDT). To achieve an efficient regional or endo-laparoscopic PDT, it is necessary to develop a highly target specific photosensitizer (PS) that can be easily treated to the lesion site with endo-laparoscopic device. Here, an ideal polymeric PS is demonstrated for effective endo-laparoscopic PDT. In the synthetic process, conventional PS (i.e., Chlorin e6, Ce6) is conjugated with an Aptamer (i.e., AS1411) targeting nucleolin (also called C23) overexpressed on the cancer cell membrane using a water-soluble polymeric linker (i.e., polyethylene glycol, PEG). The synthesized Aptamer-PEG-Ce6 could target nucleolinoverexpressing tumor cells efficiently and visualize the tumor tissues through optical and fluorescent imaging both in vitro and ex vivo, and effectively kills cancer cells under laser irradiation. Tumor staining with Aptamer-PEG-Ce6 is easily accomplished through endoscopic equipment within a few minutes. Furthermore, after laser irradiation, Aptamer-PEG-Ce6 is found to penetrate deeply into the tumor tissue and induce apoptosis of tumor cells. Taken together, the tumor-specific Aptamer-conjugated polymeric PS developed in this study has great potential as an ideal photomedicine for effective tumor treatment using endo-laparoscopic PDT.

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“…As shown in transmission electron microscopy (TEM) images ( Figure a,b; Figure S9, Supporting Information), several UCNPs are assembled to form PPNs at pH 7.4 and disassembled into isolated UCNPs at acidic condition. The PPNs are negatively charged (Figure c) with a hydrodynamic diameter of ≈120 nm (Figure d) at pH 7.4, where the fluorescence intensity and photoactivity of Ce6 in PPNs is largely quenched due to their close proximity to one another (Figure e) . Once the pH decreases to ≈6.5 in the tumor microenvironment, PPNs quickly reverse their charge to positive because of ionization of the imidazole groups (pK a ≈ 6.8).…”

mentioning

confidence: 99%

Responsive Assembly of Upconversion Nanoparticles for pH‐Activated and Near‐Infrared‐Triggered Photodynamic Therapy of Deep Tumors

et al. 2018

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Upconversion nanoparticle (UCNP)-mediated photodynamic therapy has shown great effectiveness in increasing the tissue-penetration depth of light to combat deep-seated tumors. However, the inevitable phototoxicity to normal tissues resulting from the lack of tumor selectivity remains as a major challenge. Here, the development of tumor-pH-sensitive photodynamic nanoagents (PPNs) comprised of self-assembled photosensitizers grafted pH-responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, photosensitizers aggregated in the PPNs are self-quenched; however, upon entry into a tumor microenvironment with lower pH, the PPNs not only exhibit enhanced tumor-cell internalization due to charge reversal but also are further disassembled into well-dispersed nanoparticles in the endo/lysosomes of tumor cells, enabling the efficient activation of photosensitizers. The results demonstrate the attractive properties of both UCNP-mediated deep-tissue penetration of light and high therapeutic selectivity in vitro and in vivo.

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Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer

Cited by 58 publications

References 44 publications

Dynamic Nanoparticle Assemblies for Biomedical Applications

Dynamic Nanoparticle Assemblies for Biomedical Applications

Tumor‐Specific Aptamer‐Conjugated Polymeric Photosensitizer for Effective Endo‐Laparoscopic Photodynamic Therapy

Responsive Assembly of Upconversion Nanoparticles for pH‐Activated and Near‐Infrared‐Triggered Photodynamic Therapy of Deep Tumors

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