Abstract:The preparation of substituted azetidines and larger-ring,
nitrogen-containing saturated heterocycles is enabled through efficient and
selective intermolecular sp<sup>3</sup>-C–H amination of alkyl bromide
derivatives. A range of substrates is demonstrated to undergo C–H amination and
subsequent sulfamate alkylation in good to excellent yield. <i>N</i>-Phenoxysulfonyl-protected products can
be unmasked under neutral or mild basic conditions to yield the corresponding cyclic
2° amines. T… Show more
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