Intermolecular Nucleophilic Addition Reaction of a C-7 Anion from N-[Bis(dimethylamino)phosphoryl]indole to Electrophiles/Arynes: Synthesis of 7-Substituted Indoles
Abstract:A novel approach for C-7 substitution of N-bis(dimethylamino)phosphinoyl indole by nucleophilic addition of C-7 carbanion to electrophiles and arynes is described and the directing group can be easily removed which provides a facile route for synthesis of 7-functionalized indoles.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.