Intermittent whole-body vibration attenuates a reduction in the number of the capillaries in unloaded rat skeletal muscle

Kaneguchi, Akinori; Ozawa, Junya; Kawamata, Seiichi; Kurose, Tomoyuki; Yamaoka, Kaoru

doi:10.1186/1471-2474-15-315

Cited by 21 publications

(21 citation statements)

References 45 publications

(59 reference statements)

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“…ANG is also a potent stimulator of angiogenesis, specifically up-regulating the production of proteases that degrade laminin and fibronectin, allowing endothelial cells to migrate and form new vessels (45,46). This information suggests that lack of ANG production by pericytes during IM may contribute to suppression of protein synthesis and atrophy, as well as reductions to capillary number (C/F ratio) or capillary density (capillary per square millimeter tissue) following disuse (47)(48)(49)(50). In addition to the change in Ang gene expression, the increases in Atf4 and p53 in NG2 + Lin 2 pericytes post-IM were also striking.…”

Section: Discussionmentioning

confidence: 99%

Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization

et al. 2019

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Conditions of extended bed rest and limb immobilization can initiate rapid and significant loss of skeletal muscle mass and function. Physical rehabilitation is standard practice following a period of disuse, yet mobility may be severely compromised, and recovery is commonly delayed or incomplete in special populations. Thus, a novel approach toward recovery of muscle mass is highly desired. Pericytes [neuron‐glial antigen 2 (NG2)+CD31−CD45−(Lineage− [Lin−]) and CD146+Lin−] demonstrate capacity to facilitate muscle repair, yet the ability to enhance myofiber growth following disuse is unknown. In the current study, 3–4‐mo‐old mice were unilaterally immobilized for 14 d (IM) or immobilized for 14 d followed by 14 d of remobilization (RE). Flow cytometry and targeted gene expression analyses were completed to assess pericyte quantity and function following IM and RE. In addition, a transplantation study was conducted to assess the impact of pericytes on recovery. Results from targeted analyses suggest minimal impact of disuse on pericyte gene expression, yet NG2+Lin− pericyte quantity is reduced following IM (P < 0.05). Remarkably, pericyte transplantation recovered losses in myofiber cross‐sectional area and the capillary‐to‐fiber ratio following RE, whereas deficits remained with vehicle alone (P = 0.01). These findings provide the first evidence that pericytes effectively rehabilitate skeletal muscle mass following disuse atrophy.—Munroe, M., Dvoretskiy, S., Lopez, A., Leong, J., Dyle, M. C., Kong, H., Adams, C. M., Boppart, M. D. Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization. FASEB J. 33, 7694–7706 (2019). http://www.fasebj.org

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Section: Discussionmentioning

confidence: 99%

Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization

et al. 2019

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“…One study reports no change in VEGF expression during HU-induced capillary regression, but significant reductions in the VEGF receptors, and in angiopoietin (Ang)-1 & Ang-2 signaling through its Tie-2 receptor [106]. Two other studies report decreased VEGF expression, with no significant change in TSP-1 protein expression, in conjunction with HU [52,53]. However, one of these studies report a 62-fold increase in the TSP-1 receptor CD-36 [53], suggesting that activation of TSP-1 signaling pathway was likely to occur even if TSP-1 itself was not elevated.…”

Section: Capillary Regression Correlates Better To Changes In Tsp-1 Tmentioning

confidence: 99%

“…Two other studies report decreased VEGF expression, with no significant change in TSP‐1 protein expression, in conjunction with HU . However, one of these studies report a 62‐fold increase in the TSP‐1 receptor CD‐36 , suggesting that activation of TSP‐1 signaling pathway was likely to occur even if TSP‐1 itself was not elevated. The CD36 pathway is important in this context, becuase it is believed to be the primary receptor responsible for TSP‐1 anti‐angiogenic effects .…”

Section: Introductionmentioning

confidence: 99%

Physiological Capillary Regression is not Dependent on Reducing VEGF Expression

Olfert

2016

Microcirculation

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Investigations into physiologically-controlled capillary regression report the provocative finding that microvessel regression occurs in the face of persistent elevation of skeletal muscle vascular endothelial growth factor-A (VEGF) expression. Thrombospondin-1 (TSP-1), a negative angiogenic regulator, is increasingly being observed to temporally correlate with capillary regression, suggesting that increased TSP-1 (and not reduction in VEGF per se) is needed to initiate, and likely regulate, capillary regression. Based on evidence being gleaned from physiologically-mediated regression of capillaries, it needs to be recognized that capillary regression (and perhaps capillary rarefaction with disease) is not simply the reversal of factors used to stimulate angiogenesis. Rather, the conceptual understanding that angiogenesis and capillary regression each have specific and unique requirements that are biologically constrained to opposite sides of the balance between positive and negative angioregulatory factors may shed light on why anti-VEGF therapies have not lived up to the promise in reversing angiogenesis and providing the cure that many had hoped toward fighting cancer. Emerging evidence from physiological controlled angiogenesis suggest that cases involving excessive or uncontrolled capillary expansion may be best treated by therapies designed to increase expression of negative angiogenic regulators, whereas those involving capillary rarefaction may benefit from inhibiting negative regulators (like TSP-1).

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“…The potential of a vibratory stimulus (whether applied locally or to the whole body using a platform) to increase muscle mass and performance in healthy subjects has been previously discussed [53]. Previous animal studies applying isolated vibration have reported benefits at the muscle level [21,37,74]. Yet, the potential benefits of vibration per se (i.e., independently of RET) on human muscle mass remain to be clearly shown.…”

Section: Vibrationmentioning

confidence: 99%

Passive Strategies for the Prevention of Muscle Wasting During Recovery from Sports Injuries

Morales

Lucía

2019

J. of SCI. IN SPORT AND EXERCISE

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Background Recovery from sport injuries commonly involves a muscle disuse situation (i.e., reduction in physical activity levels sometimes preceded by joint immobilization) with subsequent negative effects on muscle mass and function. Purpose To summarize the current body of knowledge on the effectiveness of different physical strategies that are currently available to mitigate the negative effects of muscle disuse during recovery from sports injury. Methods A narrative review was conducted to summarize the information available on neuromuscular electrical stimulation (NMES), blood flow restriction (BFR) and vibration intervention. Results The concomitant application of BFR and low-intensity exercise has shown promising results in the prevention of disuse-induced muscle atrophy. Some benefits might also be obtained with BFR alone (i.e., with no exercise), but evidence is still inconclusive. NMES, which can be applied both passively and synchronously with exercise, can also attenuate most of the negative changes associated with disuse periods. In turn, the mechanical stimulus elicited by vibration seems effective to reduce the loss of bone mineral density that accompanies muscle disuse and could also provide some benefits at the muscle tissue level. Conclusions Different physical strategies are available to attenuate disuse-induced negative consequences during recovery from injury. These interventions can be applied passively, which makes them feasible during the first stages of the recovery. However, it would be advisable to apply these strategies in conjunction with low-intensity voluntary exercise as soon as this is feasible.

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Intermittent whole-body vibration attenuates a reduction in the number of the capillaries in unloaded rat skeletal muscle

Cited by 21 publications

References 45 publications

Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization

Pericyte transplantation improves skeletal muscle recovery following hindlimb immobilization

Physiological Capillary Regression is not Dependent on Reducing VEGF Expression

Passive Strategies for the Prevention of Muscle Wasting During Recovery from Sports Injuries

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