Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo11Principal Investigators: D. Uebelhart, MD, Assistant Professor; M. Malaise, MD, Professor, R. Marcolongo, MD, Professor; E. Vignon, MD, Professor. Co-Investigators: M. Piperno, MD, Head Physician; E. Mailleux, MD, Head Physician; A. Fioravanti, MD, Head Physician; L. Matoso, MD, Physician; Statistical analysis: F. DeVathaire, PhD, Professor; Radiological analy

Uebelhart, Daniel; Malaise, Michel; Marcolongo, Roberto; Vathaire, Florent de; Piperno, M.; Mailleux, E; Fioravanti, Antonella; Matoso, Luis; Vignon, E.

doi:10.1016/j.joca.2004.01.004

Cited by 184 publications

(48 citation statements)

References 25 publications

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“…Most studies had a sample size larger than 50 participants; in particular, several studies had sample sizes of 100 or more (Alekseeva 1999; Alekseeva 2005a; Alekseeva 2008; Clegg 2006; Gabay 2011; Kahan 2009; L’Hirondel 1992; Mazieres 2001; Michel 2005; Moller 2010; Morreale 1996; Nasonova 2001; Pavelka 1999; Pavelka 2010; Rai 2004; Sawitzke 2008; Sawitzke 2010; Uebelhart 2004; Fardellone 2013). …”

Section: Resultsmentioning

confidence: 99%

Chondroitin for osteoarthritis

Singh

Noorbaloochi

MacDonald

et al. 2015

Cochrane Database of Systematic Reviews

180

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Section: Resultsmentioning

confidence: 99%

Chondroitin for osteoarthritis

Singh

Noorbaloochi

MacDonald

et al. 2015

Cochrane Database of Systematic Reviews

180

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“…Authors concluded that oral chondroitin sulphate is an effective and safe symptomatic slow-acting drug for the treatment of knee OA and, in addition, CS might be able to stabilise the joint space width and can modulate bone and joint metabolism. Again Uebelhart et al [84] investigated the efficacy and tolerability of a 3-month duration, twice a-year, intermittent treatment with oral chondroitin sulphate in knee osteoarthritis patients with support to previous results.…”

Section: Human Studiesmentioning

confidence: 85%

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Campo¹,

Avenoso²,

Campo³

et al. 2006

MRMC

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Most biological molecules exhibit more than one function. In particular, many molecules have the ability to directly/indirectly scavenge free radicals and thus act in living organisms as antioxidant. During oxidative stress, the increase of these molecules levels seems to be a biological response that in synergism with the other antioxidant defence systems may protect cells from oxidation. Among these structures, chondroitin sulphate is a biomolecule which has increasingly focused the interest of many research groups due to its antioxidant activity. This review briefly summarises the action of chondroitin sulphate in reducing molecular damage caused by free radicals and associated oxygen reactants.

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“…The efficacy of CS in OA treatment has been confirmed by several clinical trials [54][55][56][57][58][59][60][61][62][63][64][65] and reviewed in [66 and 67]. CS efficacy and tolerance ( Table 1) was evaluated in the therapy of tibiofibular arthritis of the knee [54] in forty patients suffering from this illness, and Oliviero et al [55] conducted a clinical trial, lasting 6 months, performed on two hundred patients.…”

Section: Cs In the Treatment Of Oamentioning

confidence: 96%

“…In the CS-treatment group, a significant decrease in the number of patients with new erosive OA was seen. In a very recent randomized, double-blind, multicenter study [63], the efficacy and tolerability of oral CS (Condrosulf ® ) in knee OA patients in a 3-month duration, twice a-year, intermittent treatment was investigated. A total of 120 patients with symptomatic knee OA were randomized into two groups receiving either 800 mg CS or placebo per day for two periods of 3 months during 1 year.…”

Section: Cs In the Treatment Of Oamentioning

confidence: 99%

Therapeutic Applications of Glycosaminoglycans

Volpi¹

2006

CMC

147

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Complex polysaccharides, hyaluronic acid or hyaluronan (HA), keratan sulfate (KS), chondroitin sulfates (CSs) and heparin (Hep)/heparan sulfate (HS), are a class of ubiquitous molecules exhibiting a wide range of biological functions. They are widely distributed as glycosaminoglycans (GAGs) sidechains of proteoglycans (PGs) in the extracellular matrix and at cellular level. The recent emergence of improved enzymatic and analytical tools for the study of these complex sugars has produced a virtual explosion in the field of glycomics. In particular, the study of the GAG family of polysaccharides has shed considerable light on the way in which specific carbohydrate structures modulate cellular phenotypes. In addition to the well-known therapeutic applications of some of these macromolecules, such as HA and derivatives as structure modifying molecules and possessing gel-like properties able to provide functional support for tissues, Hep as an anticoagulant and antithrombotic drug and CS in the treatment of osteoarthritis (OA), this increased understanding of GAG structure-function relationship has led to the discovery of novel pharmaceuticals for the possible treatment of serious diseases, such as cancer. In this paper, the structure and the therapeutic applications of several complex natural polysaccharides, including HA, CS/DS, Hep and their derivatives, are presented and discussed also in the light of the many questions still left unanswered, such as improved preparation and GAG-based drugs with improved properties and new possible therapeutic applications.

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Cited by 184 publications

References 25 publications

Chondroitin for osteoarthritis

Chondroitin for osteoarthritis

Chondroitin Sulphate: Antioxidant Properties and Beneficial Effects

Therapeutic Applications of Glycosaminoglycans

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