Intermittent theta burst stimulation over left BA10 enhances virtual reality-based prospective memory in healthy aged subjects

Debarnot, Ursula; Crépon, Benoît; Orriols, Éric; Abram, Maria; Charron, Sylvain; Lion, Stéphanie; Roca, Pauline; Oppenheim, Catherine; Guéguen, B.; Ergis, Anne-Marie; Piolino, Pascale

doi:10.1016/j.neurobiolaging.2015.05.001

Cited by 40 publications

(23 citation statements)

References 56 publications

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“…We were unable to replicate the previous study of iTBS demonstrating a significant increase in the accuracy of 2‐back task following iTBS compared to sham stimulation (Hoy et al, ). The reason for this discrepancy remains unclear, and further research is required as currently only a few studies have been performed in this area to date (Cheng et al, ; Debarnot et al, ; Demeter, Mirdamadi, Meehan, & Taylor, ; Hoy et al, ; Ryals, Rogers, Gross, Polnaszek, & Voss, ). A recent study investigated the effect of prefrontal TBS on a series of cognitive tasks, such as Digits Backward, 3‐back task, Stroop Colour and Word Test, and the Tower of Hanoi (Viejo‐Sobera et al, ).…”

Section: Discussionmentioning

confidence: 99%

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

Chung

Rogasch

Hoy

et al. 2017

Human Brain Mapping

100

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Intermittent theta burst stimulation (iTBS) is a noninvasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex. Sixteen healthy participants received iTBS over prefrontal cortex at either 50, 75 or 100% resting motor threshold in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials and oscillations. The n-back task was used to assess changes in working memory performance. The data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS yielded the largest neurophysiological changes. Improvement in reaction time in the 3-back task was supported by the change in alpha power, however, comparison between conditions revealed no significant differences. The assumption that higher intensity results in greater neuromodulatory effects may be false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.

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Section: Discussionmentioning

confidence: 99%

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

Chung

Rogasch

Hoy

et al. 2017

Human Brain Mapping

100

View full text Add to dashboard Cite

show abstract

“…This is contrary to a previous finding which demonstrated a significant increase in the accuracy of 2-back task following iTBS compared to sham stimulation (Hoy et al, 2015). The reason for this discrepancy remains unclear, and further research is required as currently only a few studies have been performed in this area to date (Cheng et al, 2016; Debarnot et al, 2015; Demeter et al, 2016; Hoy et al, 2015; Ryals et al, 2016). However, a similar lack of behavioural changes in the presence of robust neurophysiological effects after tDCS has also been described with a larger sample size (n = 20) (Hill et al, 2016), suggesting neurophysiological measures may provide a more sensitive index for assessing changes following neuromodulatory paradigms.…”

Section: Discussionmentioning

confidence: 99%

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS-EEG and working memory performance

Chung

Rogash

Hoy

et al. 2017

Preprint

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IntroductionIntermittent theta burst stimulation (iTBS) is a non-invasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects compared to conventional repetitive transcranial magnetic stimulation (rTMS) paradigms, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory effect is well established for the standard rTMS paradigms but may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex.Methods16 healthy participants received iTBS over prefrontal cortex (F1 electrode) at either 50, 75 or 100% resting motor threshold (rMT) in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials (TEPs) and TMS-evoked oscillations. The n-back task (2-back and 3-back) were used to assess changes in working memory (accuracy and reaction time).ResultsThe data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS resulted in the largest neurophysiological changes both in TMS-EEG and working memory. Even though 75% iTBS showed significantly decreased reaction time in the 3-back task, between condition comparisons revealed no significant differences.ConclusionsThe assumption that higher intensity results in greater neuromodulatory effects is false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.HighlightsEffects of prefrontal iTBS at 50, 75 and 100% rMT were investigatedInverse U-shape relationship between intensity and neurophysiological effectsEffects on the behavioural performance remain elusive in healthy individualsDisclosures and conflict of interestsSWC was supported by a Monash Graduate Scholarship. NCR is supported by a NHMRC Early Career Fellowship (1072057). KEH is supported by a NHMRC Career Development Fellowship (1082894). PBF is supported by a NHMRC Practitioner Fellowship (1078567). PBF has received equipment for research from MagVenture A/S, Medtronic Ltd, Cervel Neurotech and Brainsway Ltd and funding for research from Neuronetics and Cervel Neurotech. He is on the scientific advisory board for Bionomics Ltd. There are no other conflicts.

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“…In the case of the extant PM literature, visual stimuli are predominantly presented via either standard computer monitors (Debarnot et al, 2015;Gonneaud et al, 2012;Sakai et al, 2018) or head-mounted displays (HMD) (Parsons & Barnett, 2017;Brown et al, 2016;Banville et al, 2010). While each of these methods can make use of three-dimensional environments, they are critically different in the way they embody them.…”

Section: Virtual Reality and Prospective Memorymentioning

confidence: 99%

Naturalistic assessments in virtual reality and in real life help resolve the age-prospective memory paradox

Saito¹,

Rose²

2019

Preprint

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Age differences in prospective memory (PM)—memory for delayed intentions—have shown paradoxical patterns between laboratory and naturalistic settings. Virtual reality (VR) has been used to try and enhance the ecological validity of PM assessments, but methodological differences and limited validation have undermined interpretation of previous findings. We compared age differences between VR- and naturalistic-based measures of PM performance for younger (18-30 years) and older (56-83 years) adults (N = 111) to explore the role of task context and familiarity. Participants completed PM tasks embedded in the Job Simulator VR videogame and a Breakfast task that involved setting a table and simulating breakfast food preparation. We also included two real-world measures in which participants tried to remember to exchange personal belongings with the experimenter (Belongings task) and return phone calls at specific times outside the lab (Call-back task). We found comparable age deficits in Job Simulator and the Breakfast task. However, the age-PM paradox persisted in the Belongings and Call-back tasks. Hierarchical regression modeling was conducted to determine the roles of working memory, vigilance, and personality traits in each. Regression analyses revealed that significant variance in lab-based PM performance was accounted for by individual differences in working memory and agreeableness in older adults, while variance in naturalistic PM performance was accounted for by vigilance and neuroticism in young adults. This study suggests that immersive VR gameplay helped to provide ecologically valid PM assessment and advance a theoretical account of the age-PM paradox with a systematic, task-based analysis of age and individual differences in PM. Different mediators predicted young and older adults’ PM differently across real-world and in-lab contexts (despite measuring similar, naturalistic PM in the same individuals in both VR and in real life). There are methodological, cognitive, & personality moderators, but the “paradox” appears to be a real developmental phenomenon.

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Intermittent theta burst stimulation over left BA10 enhances virtual reality-based prospective memory in healthy aged subjects

Cited by 40 publications

References 56 publications

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS-EEG and working memory performance

Naturalistic assessments in virtual reality and in real life help resolve the age-prospective memory paradox

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