Intermittent theta burst stimulation over primary motor cortex enhances movement-related beta synchronisation

Hsu, Yi‐Cheng; Liao, Kwong‐Kum; Lee, Po-Lei; Tsai, Yun-An; Yeh, Chia-Lung; Lai, Kuan‐Lin; Huang, Ying Zu; Lin, Yung Yang; Lee, I‐Hui

doi:10.1016/j.clinph.2011.03.027

Cited by 39 publications

(28 citation statements)

References 38 publications

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“…They generally showed an association between increases of beta power and decreases in cortical excitability (Hsu et al. ; Noh et al. ; McAllister et al.…”

Section: Discussionmentioning

confidence: 97%

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Practice changes beta power at rest and its modulation during movement in healthy subjects but not in patients with Parkinson's disease

et al. 2015

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Background PD (Parkinson's disease) is characterized by impairments in cortical plasticity, in beta frequency at rest and in beta power modulation during movement (i.e., event‐related ERS [synchronization] and ERD [desynchronization]). Recent results with experimental protocols inducing long‐term potentiation in healthy subjects suggest that cortical plasticity phenomena might be reflected by changes of beta power recorded with EEG during rest. Here, we determined whether motor practice produces changes in beta power at rest and during movements in both healthy subjects and patients with PD. We hypothesized that such changes would be reduced in PD.MethodsWe thus recorded EEG in patients with PD and age‐matched controls before, during and after a 40‐minute reaching task. We determined posttask changes of beta power at rest and assessed the progressive changes of beta ERD and ERS during the task over frontal and sensorimotor regions.ResultsWe found that beta ERS and ERD changed significantly with practice in controls but not in PD. In PD compared to controls, beta power at rest was greater over frontal sensors but posttask changes, like those during movements, were far less evident. In both groups, kinematic characteristics improved with practice; however, there was no correlation between such improvements and the changes in beta power.ConclusionsWe conclude that prolonged practice in a motor task produces use‐dependent modifications that are reflected in changes of beta power at rest and during movement. In PD, such changes are significantly reduced; such a reduction might represent, at least partially, impairment of cortical plasticity.

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“…They generally showed an association between increases of beta power and decreases in cortical excitability (Hsu et al. ; Noh et al. ; McAllister et al.…”

Section: Discussionmentioning

confidence: 97%

“…), induced local changes not only in cortical excitability but also in beta power (Hsu et al. ; Noh et al. ; McAllister et al.…”

Section: Introductionmentioning

confidence: 99%

Practice changes beta power at rest and its modulation during movement in healthy subjects but not in patients with Parkinson's disease

et al. 2015

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“…On one hand, beta modulation likely reflects the interplay of sensory and motor regions' activities during motor performance (Shimazu et al, 1999; Cassim et al, 2000) with activation of motor areas and attenuation of sensory afferents during movement followed by re-activation of somatosensory areas and idle state of the motor areas. On the other side, increases of beta power have been associated with high GABA levels in animal and human studies (Jensen et al, 2005; Roopun et al, 2006; Yamawaki et al, 2008; Hall et al, 2010, 2011; Muthukumaraswamy et al, 2013; Rossiter et al, 2014) and decreases in cortical excitability in humans (Hsu et al, 2011; Noh et al, 2012; McAllister et al, 2013). Indeed, these two lines of evidence are not incompatible: the repetitive pattern of alternate activation and inactivation of the sensory and motor areas during the continuous, uninterrupted practice of a task likely triggers the induction of long term potentiation (LTP) that may reinforce existing sensory-motor memories (or internal models) or create new ones, finally resulting in skill enhancement.…”

Section: Introductionmentioning

confidence: 99%

Beta Oscillatory Changes and Retention of Motor Skills during Practice in Healthy Subjects and in Patients with Parkinson's Disease

Nelson

Moisello

Lin

et al. 2017

Front. Hum. Neurosci.

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Recently we found that modulation depth of beta power during movement increases with practice over sensory-motor areas in normal subjects but not in patients with Parkinson's disease (PD). As such changes might reflect use-dependent modifications, we concluded that reduction of beta enhancement in PD represents saturation of cortical plasticity. A few questions remained open: What is the relation between these EEG changes and retention of motor skills? Would a second task exposure restore beta modulation enhancement in PD? Do practice-induced increases of beta modulation occur within each block? We thus recorded EEG in patients with PD and age-matched controls in two consecutive days during a 40-min reaching task divided in fifteen blocks of 56 movements each. The results confirmed that, with practice, beta modulation depth over the contralateral sensory-motor area significantly increased across blocks in controls but not in PD, while performance improved in both groups without significant correlations between behavioral and EEG data. The same changes were seen the following day in both groups. Also, beta modulation increased within each block with similar values in both groups and such increases were partially transferred to the successive block in controls, but not in PD. Retention of performance improvement was present in the controls but not in the patients and correlated with the increase in day 1 modulation depth. Therefore, the lack of practice-related increase beta modulation in PD is likely due to deficient potentiation mechanisms that permit between-block saving of beta power enhancement and trigger mechanisms of memory formation.

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“…The sham stimulation was the same as described in the previous section for theta burst stimulation except for coil positioning: the coil was held perpendicular to the scalp. In this way, the orientation of the magnetic field was such that no stimulation was performed, yet the acoustic and tactile sensations were similar to the real stimulation 23 . All transcranial Doppler and magnetic stimulation measurements of cortical excitability were performed as in the real theta burst stimulation session.…”

Section: Methodsmentioning

confidence: 99%

Effects of Intermittent Theta Burst Stimulation on Cerebral Blood Flow and Cerebral Vasomotor Reactivity

Pichiorri

Vicenzini

Gilio

et al. 2012

Journal of Ultrasound in Medicine

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The expected intermittent theta burst stimulation-induced changes in cortical excitability were not accompanied by changes in cerebral blood flow velocities; however, the bilateral increased vasomotor reactivity suggests that intermittent theta burst stimulation influences the cerebral microcirculation, possibly involving subcortical structures. These findings provide useful information on hemodynamic phenomena accompanying intermittent theta burst stimulation, which should be considered in research aimed at developing this noninvasive, low-intensity stimulation technique for safe therapeutic applications.

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Intermittent theta burst stimulation over primary motor cortex enhances movement-related beta synchronisation

Cited by 39 publications

References 38 publications

Practice changes beta power at rest and its modulation during movement in healthy subjects but not in patients with Parkinson's disease

Practice changes beta power at rest and its modulation during movement in healthy subjects but not in patients with Parkinson's disease

Beta Oscillatory Changes and Retention of Motor Skills during Practice in Healthy Subjects and in Patients with Parkinson's Disease

Effects of Intermittent Theta Burst Stimulation on Cerebral Blood Flow and Cerebral Vasomotor Reactivity

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