Intermittent theta burst stimulation (iTBS) versus 10 Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) to alleviate treatment-resistant unipolar depression: A randomized controlled trial (THETA-DEP)

Bulteau, Samuel; Laurin, Alexandre; Péré, Morgane; Fayet, Guy; Thomas-Ollivier, Véronique; Deschamps, Thibault; Auffray-Calvier, E.; Bukowski, Nicolas; Vanelle, Jean-Marie; Sébille, Véronique; Sauvaget, Anne

doi:10.1016/j.brs.2022.05.011

Cited by 46 publications

(39 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, the pooled OR values of six RCTs revealed equivalent antidepressant effects between the two groups. Particularly, Bulteau et al found that both iTBS and 10 Hz rTMS still showed a similar signi cant reduction in depression scores and increase in quality of life at 6 months, not just at the acute phase [42].…”

Section: Discussionmentioning

confidence: 95%

“…Notably, although three articles compared the e cacy of TBS and rTMS, they were not included because of their retrospective design [25,39,40]. After the selection procedure, nine eligible RCTs comparing the e cacy of TBS to rTMS for treating MDD were nally selected [17,23,[41][42][43][44][45][46][47]. Among them, Chen et al (2021) included two sets of comparable trials [43], namely, 10 Hz rTMS vs. low-intensity (80% RMT) TBS and 10 Hz rTMS vs. high-intensity (120% RMT) TBS.…”

Section: Page 4/13mentioning

confidence: 99%

“…Each study used randomly assigned eligibility criteria and performed assessor blinding. Crucially, the "intention-to-treat" analysis had to be utilized in just two studies to deal with missing data [42,45]. Furthermore, this work determined the Qi based on the PEDro score for each RCT.…”

Section: Study Quality Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy and safety of theta burst versus repetitive transcranial magnetic stimulation for major depressive disorder: a meta- analysis of randomized controlled trials

Liu

Zhu

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Theta burst stimulation (TBS) is more energy- and time-efficient than standard repetitive transcranial magnetic stimulation (rTMS). However, further studies are needed to analyze TBS therapy for its efficacy and safety compared to standard rTMS for major depressive disorder (MDD). The aim of this meta-analysis was to compare TBS therapy and standard rTMS treatment regarding their safety and therapeutic effect on individuals with MDD. Methods: Six databases (Wanfang, the China National Knowledge Infrastructure, PubMed, Embase, Cochrane Library, and PsycINFO) were searched from inception till November 20, 2022. Two independent reviewers selected potentially relevant studies based on the inclusion criteria, extracted data, and evaluated the methodological quality of the eligible trials using the modified 10-item Physiotherapy Evidence Database scale per PRISMA guidelines. Finally, ten comparable pairs of 9 randomized controlled trials were included for meta-analysis. Summary odds ratios (ORs) of the rates of response, remission, and adverse events were simultaneously calculated using quality-effects (QE) and random-effects (RE) models. Changes in depression scores associated with antidepressant effects were expressed using standardized mean differences (SMDs) simultaneously. This study was registered with PROSPERO (CRD42022376790). Results: Nine of the 602 RCTs, covering 1196 cases (616 subjected to TBS protocols vs. 580 treated using standard rTMS), were enrolled. Differences in response rates between the above two treatment modalities were not significant (OR = 1.03, 95% CI: 0.90–1.18, P > 0.05, I2 = 4%, RE model; OR = 1.09, 95% CI: 0.90–1.32, P > 0.05, I2 = 4%, QE model). Differences in adverse event rates between TBS and standard rTMS groups were not statistically significant. Conclusion: TBS has similar efficacy and safety as standard rTMS for treating MDD. In light of the short duration of daily stimulation sessions, this meta-analysis supports the continued development of TBS for treating depression.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Page 4/13mentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and safety of theta burst versus repetitive transcranial magnetic stimulation for major depressive disorder: a meta- analysis of randomized controlled trials

Liu

Zhu

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Considering the lack of sustained response to ketamine monotherapy, the combination of ketamine and rTMS was suggested. During this phase of treatment, the rTMS protocol was changed to an iTBS protocol, considering the accumulating evidence of effectiveness of iTBS in treatment resistant patients ( 8 ), as well as the advantages of shorter treatment duration in regard to cost-effectiveness ( 15 ). In view of the patient’s strong response to combination treatments, as well as his history of rapid relapse, a maintenance phase was offered.…”

Section: Discussionmentioning

confidence: 99%

Transcranial magnetic stimulation and intravenous ketamine combination therapy for treatment-resistant bipolar depression: A case report

et al. 2022

View full text Add to dashboard Cite

About a third of patients suffering from major depression develop treatment-resistant depression (TRD). Although repetitive transcranial magnetic stimulation (rTMS) and intravenous ketamine have proven effective for the management of TRD, many patients remain refractory to treatment. We present the case of a patient suffering from bipolar TRD. The patient was referred to us after failure to respond to first-and second-line pharmacotherapy and psychotherapy. After minimal response to both rTMS and ketamine alone, we attempted a combination rTMS and ketamine protocol, which led to complete and sustained remission. Various comparable and complimentary mechanisms of antidepressant action of ketamine and rTMS are discussed, which support further study of this combination therapy. Future research should focus on the feasibility, tolerability, and efficacy of this novel approach.

show abstract

“…Other treatment protocols are also available [22]. iTBS is also proven to be as effective as the standard rTMS protocol with response rate of 36.7% when compared with 33.3% in standard rTMS protocol [23].…”

Section: Depressionmentioning

confidence: 99%

Transcranial Magnetic Stimulation, Connectome and Its Clinical Applications

Yuen¹

2023

Advances in Electroencephalography and Brain Connectome

View full text Add to dashboard Cite

Transcranial magnetic stimulation is an non-invasive method of neuromodulation. It uses magnetic field to induce generation of current for cortical stimulation. It can modulate the altered equilibrium in cortical excitability by magnetic field. Though it is famous for its application in treating psychiatric diseases, it has many other applications. Since its introduction in 1985, it has been used to check the integrity of motor pathway. With more understanding of the technique, it has been started to be used to check the integrity of other brain connections like speech and vision. Due to its ability of neuromodulation, it has also been used in cortical mapping in neurosurgery and neurological function rehabilitation.

show abstract

Intermittent theta burst stimulation (iTBS) versus 10 Hz high-frequency repetitive transcranial magnetic stimulation (rTMS) to alleviate treatment-resistant unipolar depression: A randomized controlled trial (THETA-DEP)

Cited by 46 publications

References 70 publications

Efficacy and safety of theta burst versus repetitive transcranial magnetic stimulation for major depressive disorder: a meta- analysis of randomized controlled trials

Efficacy and safety of theta burst versus repetitive transcranial magnetic stimulation for major depressive disorder: a meta- analysis of randomized controlled trials

Transcranial magnetic stimulation and intravenous ketamine combination therapy for treatment-resistant bipolar depression: A case report

Transcranial Magnetic Stimulation, Connectome and Its Clinical Applications

Contact Info

Product

Resources

About