Intermittent preventive treatment with Sulfadoxine pyrimethamine for malaria: a global overview and challenges affecting optimal drug uptake in pregnant women

Nana, Rodrigue Roman Dongang; Hawadak, Joseph; Foko, Loick Pradel Kojom; Kumar, Amit; Chaudhry, Shewta; Arya, Aditi; Singh, Vineeta

doi:10.1080/20477724.2022.2128563

Cited by 10 publications

(4 citation statements)

References 128 publications

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“…IPT protected parturient from malaria attack, evidenced by the fact that the proportion of parturient who took IPT and still had malaria attack was about (40.1%) compared to (47.8%) of the pregnant women who did not take IPT but rather made use ITNs. This result agreed with a study where those who took IPT 23% still have malaria infection compared to 78% of those who did not take IPT, a significant observation in keeping with other studies in Nigeria [4] and elsewhere [41] .…”

Section: Discussionsupporting

confidence: 92%

“…Malaria in pregnancy is a colossal unrestricted health predicament that affects about 25 million women in malaria-endemic areas every year [2,3] . Pregnant women, mostly primigravidae and secundigravidae are predominantly susceptible to malaria than nonpregnant women from the same area [4] . Malaria in pregnancy has remained the major source of maternal, infant morbidity and mortality, though it is an avertable and transmittable disease.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of malaria and its intervention measures among pregnant women in Orlu local government area of Imo State

EO,

CN,

BEB

2023

J. Entomol. Zool. Stud.

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Assessment of the prevalence of malaria in pregnant women and its intervention measures was investigated between March and August, 2022. A total of 428 pregnant women not less than 15 years were randomly recruited from five (5) hospitals in Orlu. Result revealed that age group 31-40years, participants with tertiary education, traders/farmers recorded highest participation. Multigravid (50.5%) participated more in the study, followed by secundigravid (33.9%) and primigravid (15.7%) as the least participants; while 55.4% of the participants were in their 3 rd trimester. Overall prevalence (42.9%) of malaria was reported among pregnant women under study. Socio-demographic prevalence of the pregnant women shows that age group 21-30years (55.2%), participants with tertiary education (56.7%), and civil servants (50.0%) recorded highest prevalence. Also, it was observed that multigravid (51.4%) had highest prevalence. Result observed no difference in the prevalence significant between primigravid and secundigravid likewise in their trimesters. Participants with ITNs and IPTp usage recorded (47.8% versus 40.1%) prevalence. From the assessment, it was observed that 155(36.2%) pregnant women use IPTp only, 59(13.8%) use ITNs only while 214(50.0%) combine both IPTp + ITNs. The participants 239(55.8%) reported fansidar (Sulfadoxine -Pyrimethamine) as the most preferred drug for malaria treatment during pregnancy. Malaria drug with 3 tablets 357(83.4%) was most preferred; most pregnant women 218(50.9%) reported taking the drug once in 2-3 months while the major source of drug procurement reported healthcare facility 281(65.7%). The use of ITNs should be encouraged during pregnancy as well as the use of intermittent preventive therapy in pregnancy (IPTp) to ensure reduction in the incidence of malaria disease.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Prevalence of malaria and its intervention measures among pregnant women in Orlu local government area of Imo State

EO,

CN,

BEB

2023

J. Entomol. Zool. Stud.

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“…After sequence alignment nucleotide positions which displayed two peaks at one locus in chromatogram were noted as ‘‘mixed’’ and excluded from further analysis. Known point mutations in P. falciparum genes associated with anti-malarial drug resistance (CQ, SP, ART and its derivatives), and novel mutations were identified using their corresponding amino acids and haplotypes [ 8 , 36 ]. Regarding P. vivax isolates, putative drug resistance-associated mutations were also investigated [ 37 – 40 ] (Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Nationwide spatiotemporal drug resistance genetic profiling from over three decades in Indian Plasmodium falciparum and Plasmodium vivax isolates

Kojom Foko,

Narang,

Jakhan

et al. 2023

Malar J

Self Cite

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Background Drug resistance is a serious impediment to efficient control and elimination of malaria in endemic areas. Methods This study aimed at analysing the genetic profile of molecular drug resistance in Plasmodium falciparum and Plasmodium vivax parasites from India over a ~ 30-year period (1993–2019). Blood samples of P. falciparum and/or P. vivax-infected patients were collected from 14 regions across India. Plasmodial genome was extracted and used for PCR amplification and sequencing of drug resistance genes in P. falciparum (crt, dhps, dhfr, mdr1, k13) and P. vivax (crt-o, dhps, dhfr, mdr1, k12) field isolates. Results The double mutant pfcrtSVMNT was highly predominant across the country over three decades, with restricted presence of triple mutant CVIET from Maharashtra in 2012. High rates of pfdhfr-pfdhps quadruple mutants were observed with marginal presence of “fully resistant” quintuple mutant ACIRNI-ISGEAA. Also, resistant pfdhfr and pfdhps haplotype has significantly increased in Delhi between 1994 and 2010. For pfmdr1, only 86Y and 184F mutations were present while no pfk13 mutations associated with artemisinin resistance were observed. Regarding P. vivax isolates, the pvcrt-o K10 “AAG” insertion was absent in all samples collected from Delhi in 2017. Pvdhps double mutant SGNAV was found only in Goa samples of year 2008 for the first time. The pvmdr1 908L, 958M and 1076L mutations were highly prevalent in Delhi and Haryana between 2015 and 2019 at complete fixation. One nonsynonymous novel pvk12 polymorphism was identified (K264R) in Goa. Conclusions These findings support continuous surveillance and characterization of P. falciparum and P. vivax populations as proxy for effectiveness of anti-malarial drugs in India, especially for independent emergence of artemisinin drug resistance as recently seen in Africa.

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“…Для хлоридина характерен длинный период полувыведения, который составляет 80-100 часов. У пациентов с длительный курсом лечения хлоридином из побочных эффектов чаще всего встречаются симптомы анемии [47].…”

Section: противомикробная антигрибковая и противопаразитарная активностьunclassified

Review of Pyrimidine Derivatives as Pharmacologically Active Compounds

Chiriapkin

2022

Juvenis scientia

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Pyrimidine derivatives represent an extensive class of organic compounds that contain in their structure a six-membered heterocycle with two nitrogen atoms at positions 1 and 3. Substances of this group have a wide range of pharmacological activity, which makes it possible to consider the pyrimidine core as a promising scaffold for the development of new biologically active compounds. The article provides an analysis of the literature data of pyrimidine derivatives used in medical practice. For example, there are substances with antiviral, psychotropic, antimicrobial, antitumor, antifungal, antiparasitic and anabolic activity. Based on the structure-activity relationship of pyrimidine structures of active drugs, as well as other compounds that are considered candidates for the development of new drugs, it is possible to search for and design compounds with the desired types of pharmacological activity. Thus, a systematic analysis of pyrimidine derivatives from a pharmacological point of view can serve as a basis for further search for new highly effective and safe medicines.

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Intermittent preventive treatment with Sulfadoxine pyrimethamine for malaria: a global overview and challenges affecting optimal drug uptake in pregnant women

Cited by 10 publications

References 128 publications

Prevalence of malaria and its intervention measures among pregnant women in Orlu local government area of Imo State

Prevalence of malaria and its intervention measures among pregnant women in Orlu local government area of Imo State

Nationwide spatiotemporal drug resistance genetic profiling from over three decades in Indian Plasmodium falciparum and Plasmodium vivax isolates

Review of Pyrimidine Derivatives as Pharmacologically Active Compounds

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