Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine against Malaria and Anemia in Pregnant Women

Wilson, Nana O.; Ceesay, Fatou K.; Obed, Samuel A.; Adjei, Andrew A.; Gyasi, Richard K.; Rodney, Patricia; Ndjakani, Yassa; Anderson, Winston A.; Lucchi, Naomi W.; Stiles, Jonathan K.

doi:10.4269/ajtmh.2011.10-0512

Cited by 52 publications

(56 citation statements)

References 74 publications

(108 reference statements)

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“…We show in this study that, pregnant women who took two doses of SP were not significantly protected against PM, LBW, MA. Preliminary data from previous studies have suggested a continued trend in reduction of effectiveness of SP for IPTp in many African countries 13,37,39 .…”

Section: Discussionmentioning

confidence: 99%

Risk factors for placental malaria and associated adverse pregnancy outcomes in Rufiji, Tanzania: a hospital based cross sectional study

Ndeserua¹,

Juma²,

Mosha³

et al. 2015

Afr H. Sci.

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Background: Prevention and treatment of malaria during pregnancy is crucial for reduction of malaria in pregnancy and its adverse outcomes. The spread of parasite resistance to Sulphadoxine-Pyrimethamine (SP) used for Intermittent Preventive Treatment for malaria in pregnancy (IPTp), particularly in East Africa has raised concerns about the usefulness and the reliability of the IPTp regimen. We aimed to assess the effectiveness of two doses of SP in treating and preventing occurrence of adverse pregnancy outcomes. Methodology: The study was an analytical cross sectional study which enrolled 350 pregnant women from Kibiti Health Centre, South Eastern Tanzania. Structured questionnaires were used to obtain previous obstetrics and medical history of participants and verified by reviewing antenatal clinic cards. Maternal placental blood samples for microscopic examination of malaria parasites were collected after delivery. Data was analyzed for associations between SP dosage, risk for PM and pregnancy outcome. Sample size was estimated based on precision Results: Prevalence of placental maternal (PM) was 8% among pregnant women (95%CI, 4.4-13.1%). Factors associated with increased risk of PM were primigravidity (P<0.001) and history of fever during pregnancy (P= 0.02). Use of at least 2 doses of SP for IPTp during pregnancy was insignificantly associated with reducing the risk PM (P=0.08), low birth weight (P=0.73) and maternal anemia (P=0.71) but associated significantly with reducing the risk of preterm birth (P<0.001). Sci. 2015;15(3):810-8. doi: http://dx.doi.org/10.4314/ahs.v15i3.15

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Section: Discussionmentioning

confidence: 99%

Risk factors for placental malaria and associated adverse pregnancy outcomes in Rufiji, Tanzania: a hospital based cross sectional study

Ndeserua¹,

Juma²,

Mosha³

et al. 2015

Afr H. Sci.

View full text Add to dashboard Cite

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“…There was no statistical difference in the incidence of preterm delivery (P=0.262), cord blood parasitaemia (P=0.385), low birth weight (P=0.175) and birth asphyxia (P=0.367) between the two study groups. So, the authors conclude that there was no significant difference between intermittent preventive treatment with sulphadoxinepyrimethamine and the use of daily proguanil so larger studies with proguanil are warranted 92 . Additionally, another cross sectional study was conducted to evaluate the effectiveness of Intermittent Preventive Treatment with SP among pregnant women attending the antenatal clinic at Korle-Bu Teaching Hospital in Accra, Ghana.…”

Section: Intermittent Anti Malaria Therapymentioning

confidence: 98%

Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

Tsegaye¹,

Tesfaye²

2014

Int. Res. J. Pharm.

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Anemia is a major global health problem, especially in developing countries and is a common and serious problem in pregnancy. It has serious short-and long-term consequences during pregnancy and beyond. This fundamental health issue has not still been solved but continues to exist affecting the health, quality of life and working capacity in billions of people all over the world. The anemic condition is often worsened by the presence of other chronic diseases such as malaria, tuberculosis, HIV, and diabetes. Untreated anemia also leads to increased morbidity and mortality from these chronic conditions as well. Current knowledge indicates that iron deficiency anemia in pregnancy is a risk factor for preterm delivery and subsequent low birth weight, and possibly for inferior neonatal health. Even for women who enter pregnancy with reasonable iron stores, iron supplements improve iron status during pregnancy and for a considerable length of time postpartum, thus providing some protection against iron deficiency in the subsequent pregnancy. This literature review focuses on the prevalence and major causes of anemia seen on a global & Ethiopian scale. Most cases of anemia are due to iron deficiency, which often work in combination with folate deficiency and/or vitamin B12 deficiency as well as with infections. More efforts should be dedicated to tackle this massive problem-we have the tools and we know the ways. Iron fortification of appropriate food items combined with iron supplements in specific population groups has proved to be efficient. Initially, the efforts should be centered on the specific risk groups for iron deficiency anemia, i.e. pregnant women.

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“…The 2011 multiple indicator cluster survey from Ghana indicated progress on IPTp in Ghana although this has not been sustained 11 . IPTp-SP administered to pregnant women in their second and third trimesters has been observed to reduce the risk of malaria 12,13 , placental malaria 8 , low birth weight and preterm births [12][13][14] , and maternal anaemia 13,15 . SP has a good safety profile 16 , and is cheap, cost effective and easy to administer through the already existing antenatal-care clinics (ANC) 10,17 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP) use during pregnancy and other associated factors in Sekondi-Takoradi, Ghana

Orish¹,

Onyeabor²,

Boampong³

et al. 2016

Afr H. Sci.

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Background: Intermittent preventive treatment in pregnancy (IPTp) with sulphadoxine-pyrimethamine (SP) has been adopted as policy by most countries in sub-Saharan Africa. This cross-sectional study assessed the prevalence of IPTp-SP usage for prevention of malaria among pregnant women as well as evaluated factors associated with IPTp-SP use during pregnancy in Sekondi-Takoradi region of Ghana. Methods: Pregnant women attending their antenatal-care with either clinical/ultrasound evidence of pregnancy were recruited. Venous blood was screened for malaria using RAPID response antibody kit and Giemsa staining. Haemoglobin estimations were done by cyanmethemoglobin method while Human Immunodeficiency Virus (HIV) screening was performed by the national diagnostic algorithm of two rapid antibody test and western blot confirmation. Results: Of the 754 consented pregnant women interviewed in this study, 57.8% had received IPTp-SP while 42.2% had not at their first contact with the study personnel. Furthermore, 18.6% (81/436) of those that received IPTp-SP were malaria positive while 81.4% (355/436) were malaria negative. The results also indicated that 47.7% (51/107) of the pregnant women in their third trimester who were meant to have received at least two-doses of SP had received ≥2 doses while 35.5% (38/107) had received 1 dose. In multivariable logistic regression analysis, pregnant women in their third trimester who received ≥2 doses of SP showed decreased likelihoods of malaria (adjusted OR, 0.042; 95% CI, 0.003-0.51; P = 0.013). Conclusion: IPTp-SP usage among pregnant women in Sekondi-Takoradi reduces malaria and its use for malaria prevention should be strengthened with proper dosage completion and coverage. Keywords: Malaria in pregnancy, IPTp-SP, anaemia, Ghana DOI: http://dx.doi.org/10.4314/ahs.v15i4.6 Cite as: Orish VN, Onyeabor OS, Boampong JN , Afoakwah R, Nwaefuna E, Acquah S, et al. Prevalence of intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP) use during pregnancy and other associated factors in Sekondi-Takoradi, Ghana. Afri Health Sci. 2015;15(4):1087-96. http://dx.doi.org/10.4314/ahs.v15i4.6

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Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine against Malaria and Anemia in Pregnant Women

Cited by 52 publications

References 74 publications

Risk factors for placental malaria and associated adverse pregnancy outcomes in Rufiji, Tanzania: a hospital based cross sectional study

Risk factors for placental malaria and associated adverse pregnancy outcomes in Rufiji, Tanzania: a hospital based cross sectional study

Prevalence of Anemia Among Pregnant Women in Ethiopia and Its Management: A Review

Prevalence of intermittent preventive treatment with sulphadoxine-pyrimethamine (IPTp-SP) use during pregnancy and other associated factors in Sekondi-Takoradi, Ghana

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