Intermittent Preventive Treatment (IPT) and the Spread of Drug Resistant Malaria

Teboh-Ewungkem, Miranda I.; Prosper, Olivia; Gurski, Katharine; Manore, Carrie; Peace, Angela; Feng, Zhilan

doi:10.1007/978-1-4939-2782-1_9

Cited by 5 publications

(22 citation statements)

References 16 publications

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“…Since 2010, active malaria intervention control strategies have had a positive effect on lowering malaria burden and morbidity in Africa and worldwide. These strategies include the use of long-lasting insecticide-treated nets (ITNs), indoor residual spraying, 4 and timely access to antimalarial drugs, including the use of intermittent preventive treatment aimed at killing forms of the malaria parasite in infected individuals, 5 , 6 , 7 in addition to the other mechanisms aimed at disrupting the transmission of malaria by exploiting the feeding behaviour and gonotrophic and reproductive cycles of mosquitoes. 8 , 9 , 10 , 11 However, despite the progress of the past decade, evidence suggests that the rate of reduction in malaria mortality in the WHO African Region has slowed since 2016, although total deaths due to malaria decreased overall.…”

mentioning

confidence: 99%

COVID-19 in malaria-endemic regions: potential consequences for malaria intervention coverage, morbidity, and mortality

Teboh-Ewungkem

Ngwa

2021

The Lancet Infectious Diseases

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mentioning

confidence: 99%

COVID-19 in malaria-endemic regions: potential consequences for malaria intervention coverage, morbidity, and mortality

Teboh-Ewungkem

Ngwa

2021

The Lancet Infectious Diseases

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“…Moreover, p(x 1 , t) = P p(x, t) . Applying P to the Liouville equation (9) and formally integrating out the orthogonal dynamics Qp yields the Mori-Zwanzig (MZ) equation [28,27] ∂p(x 1 , t) ∂t = P LP p(x 1 , t) + As demonstrated in [8], there exists a duality between the MZ-PDF equation (39) and the more classical MZ formulation in the space of observables (see [11,5]). Such duality is the same that pairs the Frobenious-Perron and the Koopman operators we discussed in Section 1.…”

Section: Data-driven Estimation Of the Mori-zwanzig Memory Integralmentioning

confidence: 99%

“…In this section we apply the mathematical methods presented in Sections 1-5 to a high-dimensional nonlinear dynamical system and a drug-resistant malaria propagation model [20,9].…”

Section: Numerical Examplesmentioning

confidence: 99%

“…The following dynamical system was proposed in [9,20] to model efficacy of intermittent preventative treatment (IPT) for battling drug resistant malaria.…”

Section: Drug Resistant Malaria Propagation Modelmentioning

confidence: 99%

“…Remark 1.1. By using the method of characteristics [24], it is easy to obtain the following formal solution to (9) p(x, t) = p 0 (x 0 (x, t)) .…”

Section: Introductionmentioning

confidence: 99%

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Data-driven closures for stochastic dynamical systems

Brennan

Venturi

2018

Journal of Computational Physics

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In this paper we develop a new data-driven closure approximation method to compute the statistical properties of quantities of interest in high-dimensional stochastic dynamical systems. The new method relies on estimating conditional expectations from sample paths or experimental data, and it is independent of the dimension of the underlying phase space. We also address the important question of whether enough useful data is being injected into the reduced-order model governing the quantity of interest. To this end, we develop a new paradigm to measure the information content of data based on the numerical solution of hyperbolic systems of equations. The effectiveness of the proposed new methods is demonstrated in applications to nonlinear dynamical systems and models of systems biology evolving from random initial states.

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Intermittent Preventive Treatment (IPT): Its Role in Averting Disease-Induced Mortality in Children and in Promoting the Spread of Antimalarial Drug Resistance

et al. 2018

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We develop an age-structured ODE model to investigate the role of intermittent preventive treatment (IPT) in averting malaria-induced mortality in children, and its related cost in promoting the spread of antimalarial drug resistance. IPT, a malaria control strategy in which a full curative dose of an antimalarial medication is administered to vulnerable asymptomatic individuals at specified intervals, has been shown to reduce malaria transmission and deaths in children and pregnant women. However, it can also promote drug resistance spread. Our mathematical model is used to explore IPT effects on drug resistance and deaths averted in holoendemic malaria regions. The model includes drug-sensitive and drug-resistant strains as well as human hosts and mosquitoes. The basic reproduction, and invasion reproduction numbers for both strains are derived. Numerical simulations show the individual and combined effects of IPT and treatment of symptomatic infections on the prevalence of both strains and the number of lives saved. Our results suggest that while IPT can indeed save lives, particularly in high transmission regions, certain combinations of drugs used for IPT and to treat symptomatic infection may result in more deaths when resistant parasite strains are circulating. Moreover, the half-lives of the treatment and IPT drugs used play an important role in the extent to which IPT may influence spread of the resistant strain. A sensitivity analysis indicates the model outcomes are most sensitive to the reduction factor of transmission for the resistant strain, rate of immunity loss, and the natural clearance rate of sensitive infections.

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Intermittent Preventive Treatment (IPT) and the Spread of Drug Resistant Malaria

Cited by 5 publications

References 16 publications

COVID-19 in malaria-endemic regions: potential consequences for malaria intervention coverage, morbidity, and mortality

COVID-19 in malaria-endemic regions: potential consequences for malaria intervention coverage, morbidity, and mortality

Data-driven closures for stochastic dynamical systems

Intermittent Preventive Treatment (IPT): Its Role in Averting Disease-Induced Mortality in Children and in Promoting the Spread of Antimalarial Drug Resistance

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