Intermittent pneumatic compression as an adjuvant therapy in venous ulcer disease

Kumar, Senthil; Samraj, Kumrakrishnan; Nirujogi, Vijaya; Budnik, Julia; Walker, Michael A

doi:10.1016/s0965-206x(02)80013-4

Cited by 31 publications

(17 citation statements)

References 12 publications

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“…Adequate circulation is a healing prerequisite, 33 and IPC has displayed positive effects in treating lower limb ulceration and ischemic wound healing. 5,6 IPC also promotes fracture healing by enhancing callus formation and biomechanical strength. 7,8 Despite these positive results, little research has been conducted on how IPC affects connective tissue healing, and the regulatory mechanisms of IPC remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: A study in the rat

Dahl

Bring

et al. 2007

Journal Orthopaedic Research

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Intermittent pneumatic compression (IPC) is a treatment method to decrease venous stasis and stimulate blood flow. Recently, it was hypothesized that IPC may exert positive effects on tissue healing, a process highly dependent upon adequate circulation. In this study, we investigated the effects of daily 1-h IPC treatment during 2 and 4 weeks post-rat Achilles tendon rupture. The tendons were subjectively and semiquantitatively analyzed for collagen organization, fibroblast density, angiogenesis, and the occurrence of sensory neuropeptides, substance P (SP) and calcitonine gene related peptide (CGRP), as well as for a nerve regeneration marker, growth associated protein 43 (GAP-43). After 2 weeks of treatment, fibroblast density increased by 53% ( p ¼ 0.0004), vessel density by 64% ( p ¼ 0.022), and the occurrence of SP by 110% ( p ¼ 0.047) and CGRP by 47% ( p ¼ 0.0163) compared to untreated controls. Following 4 weeks of treatment, both the occurrence of sensory neuropeptides and the vessel density remained significantly higher ( p < 0.05), whereas fibroblast density returned to normal. However, at 4 weeks the treated tendons displayed a higher degree of organized parallel collagen fibers, a sign of increased maturation. Daily IPC treatment improves neurovascular ingrowth and fibroblast proliferation in the healing tendon and may accelerate the repair process. ß

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Section: Introductionmentioning

confidence: 99%

Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: A study in the rat

Dahl

Bring

et al. 2007

Journal Orthopaedic Research

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“…Intermittent pneumatic compression (IPC) improves venous flow significantly in patients using elastic bandages, 237 while, in combination with elastic stockings, it has been shown to increase healing rates and overall healing of venous ulcers compared with elastic stockings alone. 238 Three subsequent trials either failed to demonstrate any benefit when IPC was used in conjunction with compression, 239 or this was marginally significant. 240,241 This raises concerns regarding its efficacy.…”

Section: Venous Ulcer Recurrence Scientific Evidencementioning

confidence: 99%

Editor's Choice – Management of Chronic Venous Disease

Davies

2015

European Journal of Vascular and Endovascular Surgery

678

218

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“…Kumar and colleagues studied two groups of patients [42]. In the first, comprising 47 patients with active ulcers, they all had weekly four-layer bandaging and in addition, 22 had below-knee single-chamber IPC (90 s inflation and 90 s deflation) for 1 h twice daily at 60 mm Hg, for 4 months or until the ulcer has healed.…”

Section: Ipc Fitmentioning

confidence: 99%

Use of Intermittent Pneumatic Compression in the Treatment of Venous Ulcers

Kalodiki

2007

Future Cardiol.

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Venous ulcers affect up to 1% of the population. This review provides the hemodynamic, hematologic and clinical effects of intermittent pneumatic compression (IPC) in the treatment of venous ulcers. It presents the different IPCs and their application on venous disease. It points out that a large randomized study on IPC versus standard four-layer compression in the treatment of venous ulcers is needed. The cost-effectiveness of IPC in the treatment of venous ulcers should also be assessed.

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Intermittent pneumatic compression as an adjuvant therapy in venous ulcer disease

Cited by 31 publications

References 12 publications

Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: A study in the rat

Intermittent pneumatic compression enhances neurovascular ingrowth and tissue proliferation during connective tissue healing: A study in the rat

Editor's Choice – Management of Chronic Venous Disease

Use of Intermittent Pneumatic Compression in the Treatment of Venous Ulcers

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