2004
DOI: 10.1016/s0003-4975(03)01338-9
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Intermittent infusion of 0.25% bupivacaine through an intrapleural catheter for post-thoracotomy pain relief

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Cited by 30 publications
(18 citation statements)
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“…Previous studies have showed that the intrapleural side effects of morphine are very low. Teik observed greater analgesic effect of intrapleural bupivacaine compared to saline 23. In contrast, several studies have reported limited effectiveness of this method19,24 which may be due to drug dilution in the pleural space and drug drainage through chest tubes may lead to less drug concentration at the site of the receptors and insufficient analgesic effect.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies have showed that the intrapleural side effects of morphine are very low. Teik observed greater analgesic effect of intrapleural bupivacaine compared to saline 23. In contrast, several studies have reported limited effectiveness of this method19,24 which may be due to drug dilution in the pleural space and drug drainage through chest tubes may lead to less drug concentration at the site of the receptors and insufficient analgesic effect.…”
Section: Discussionmentioning
confidence: 99%
“…Other side effects of intrapleural block include respiratory arrest, which was reported in a narcotized patient [80] and Horner's syndrome [81]. Nevertheless, intrapleural analgesia resulted in the improvement of respiratory performance as well as a decrease in pulmonary complications in postoperative CABG patients with concomitant chronic obstructive pulmonary disease (COPD) [74], as previously reported in postthoracotomy patients [44, 50, 82]. …”
Section: Treatmentsmentioning
confidence: 65%
“…While there are reports which address safety and advantages of intrapleural block in postthoracotomy patients [4350], most other studies showed little or no benefit for ISP [11, 5155]. As an interesting finding, intrapleural block could not decrease epidural analgesia requirement and have little effect on intercostal incisional pain after thoracotomy, too [11, 57].…”
Section: Treatmentsmentioning
confidence: 99%
“…Several reports have described effectiveness of IPA as postoperative pain relief for thoracic surgery, [5][6][7][8] but some reports have been only mildly positive 9) or frankly negative. 10,11) These conflicting results may be due to a variety of the applications and the study settings.…”
Section: Discussionmentioning
confidence: 99%